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Albtm1(cre/ERT2)Mtz - Liver And Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Albtm1(cre/ERT2)Mtz
albumin; targeted mutation 1, Daniel Metzger
Driver: Alb
Type: Targeted (Inducible, Recombinase)
Inducer: induced by tamoxifen
Synonym: Alb-CreERT2, Albtm1(cre/ESR1)Mtz, Albumin-CreER, SACre-ERT2, SA-CRE-ERT2
Molecular description: A vector was used to insert IRES-Cre-ERT2 downstream of the stop codon in exon 14. Transient FLP-recombinase excised a FRT-floxed neo 3' to the Cre. ES cell clone XF136.64 was injected into blastocysts to generated mice. Southern blot confirmed recombination. RT-PCR indicated bicistronic expression was only present in the liver of mutants. Immunohistochemical analysis of liver using an anti-Cre antibody showed that Cre is expressed in most, if not all, hepatocytes.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Liver And Biliary System Other recombinase alleles with activity in Liver And Biliary System tissues:
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J:92298 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory