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Eportm1(EGFP/cre)Uk - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Eportm1(EGFP/cre)Uk
erythropoietin receptor; targeted mutation 1, Ursula Klingmuller
Driver: Epor
Type: Targeted (Recombinase, Reporter)
Synonym: EpoRCre, EpoR-iCre, ErGFPcre
Molecular description: An EGFPcre sequence was inserted into exon 1, replacing the endogenous ATG with the translational start site of the EGFPcre, yet preserving the last 10 bp of the splice-donor site of exon 1. A FRT flanked neo was inserted downstream to replace parts of exon 2 and exons 3-8. Transient FLP expression excised the neo. Southern blot and multiplex PCR confirmed recombination in hemizygous mice. Immunoblot of FLCs demonstrated green fluorescence in hemizygous and homozygous embryos, with homozygotes showing a 2-fold increase in fluorescence intensity compared to hemizygotes.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Eportm1(EGFP/cre)Uk activity also observed in:
liver and biliary system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory