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Eportm1.1(EGFP/icre)Uk - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Eportm1.1(EGFP/icre)Uk
erythropoietin receptor; targeted mutation 1.1, Ursula Klingmuller 		Driver: Epor
Type: Targeted (Null/knockout, Recombinase, Reporter)
Synonym: EpoRCre, EpoR-iCre, Eportm1.1(EGFP/icre)Uk, ErGFPcre
Molecular description: An EGFP/icre sequence was inserted into exon 1, replacing the endogenous ATG with the translational start site of the EGFP/icre, yet preserving the last 10 bp of the splice-donor site of exon 1. A FRT flanked neo was inserted downstream to replace parts of exon 2 and exons 3-8. Transient FLP expression excised the neo. Southern blot and multiplex PCR confirmed recombination in heterozygous mice. Immunoblot of FLCs demonstrated green fluorescence in heterozygous and homozygous embryos, with homozygotes showing a 2-fold increase in fluorescence intensity compared to heterozygotes.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Eportm1.1(EGFP/icre)Uk activity also observed in:
cardiovascular system, hemolymphoid system, liver & biliary system, respiratory system
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:312924 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 75 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory