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Gabra6tm2(cre)Wwis - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Gabra6tm2(cre)Wwis
gamma-aminobutyric acid type A receptor subunit alpha 6; targeted mutation 2, W Wisden 		Driver: Gabra6
Type: Targeted (Recombinase)
Synonym: delta alpha6Cre
Molecular description: Exon 8 was disrupted by insertion, via homologous recombination, of a TAG3 IRES-nlsCre-neo cassette, which contains stop codons in all reading frames followed by an encephalomyelocarditis virus internal ribosome entry site (IRES), the coding sequence for Cre recombinase flanked by the nuclear localization sequence and polyadenylation signal from SV40, and a neomycin resistance gene driven by the HSV promoter. Cre was shown, both by immunohistochemistry and by X-gal staining of brains of adult F1 progeny from a cross to a beta-galactosidase expressing Cre reporter strain, to be expressed uniformly in nuclei of all cells of the granule cell layer and, additionally, in a few Purkinje cells and in some small cells in the molecular layer.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Gabra6tm2(cre)Wwis activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:91624 Fig. 2 J:91624 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory