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HhatTg(TFAP2A-cre)1Will - Sensory Organs
Recombinase Activity Detail
Allele Information
Allele:
HhatTg(TFAP2A-cre)1Will
hedgehog acyltransferase; transgene insertion 1, Trevor Williams
Driver: TFAP2A
Type: Transgenic (Recombinase)
Synonym: Ap2-Cre, AP-2CRE, CrefaceT
Molecular description: This transgenic construct consisted of 200 bp of human TFAP2A (TCFAP2A) promoter sequence (encoding a specific enhancer element) followed by NLS-cre, an SV40 polyA signal, and a 1.8 kb TFAP2A genomic fragment extending from within exon 5 through a portion of exon 6. The human intron 5 sequence includes the frontonasal prominence- and limb-specific enhancer. Expression of cre recombinase was detected in the embryonic face and limb mesenchyme. New research has determined that the transgene inserted into intron 9 of the Hhat locus. This insertion creates a non-functional allele. No viable homozygotes are recovered at birth and embyros display a variety of craniofacial defects
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: HhatTg(TFAP2A-cre)1Will activity also observed in:
Tissue Information
Sensory Organs Other recombinase alleles with activity in Sensory Organs tissues:
Images
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J:88829 Fig. 11 J:88829 Fig. 2 J:88829 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory