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Allele Information
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Allele:
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HhatTg(TFAP2A-cre)1Will
hedgehog acyltransferase;
transgene insertion 1, Trevor Williams
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Driver: TFAP2A
Type: Transgenic (Cre/Flp)
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Synonym:
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AP-2CRE, CrefaceT
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Molecular description:
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This transgenic construct consisted of 200 bp of human TFAP2A (TCFAP2A) promoter sequence (encoding a specific enhancer element) followed by NLS-cre, an SV40 polyA signal, and a 1.8 kb TFAP2A genomic fragment extending from within exon 5 through a portion of exon 6. The human intron 5 sequence includes the frontonasal prominence- and limb-specific enhancer. Expression of cre recombinase was detected in the embryonic face and limb mesenchyme. New research has determined that the transgene inserted into intron 9 of the Hhat locus.
This insertion creates a non-functional allele. No viable homozygotes are recovered at birth and embyros display a variety of craniofacial defects
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Find mice (IMSR):
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Mouse Strains:
0 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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HhatTg(TFAP2A-cre)1Will activity also observed in:
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Tissue Information
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Branchial Arches
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Other recombinase alleles with activity in Branchial Arches tissues:
Dmbx1tm3(cre)Aoh,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Fgf16tm1.1(cre)Sms,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxg1tm1(cre)Skm,
Foxn1tm3(cre)Nrm,
Hoxa3tm1(cre)Moon,
Hoxb1tm1(cre)Og,
Krt19tm1(cre)Mmt,
Mesp1tm2(cre)Ysa,
Myf5tm3(cre)Sor,
Nkx2-5tm1(cre)Rjs,
Nkx2-5tm2(cre)Rph,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Osr2tm2(cre)Jian,
Pax3tm1(cre)Joe,
Shhtm1(EGFP/cre)Cjt,
Tbx1tm4(cre/Esr1*)Bld,
Tfap2atm1(cre)Moon,
Tg(CMV-cre)1Cgn,
Tg(Col2a1-cre)1Asz,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(EIIa-cre)C5379Lmgd,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Fgf15-cre)1Bld,
Tg(Fgf15/Hsp68-cre)1Bld,
Tg(Frzb-cre)1Tylz,
Tg(GFAP-cre)25Mes,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand2-cre)7-1Clou,
Tg(Hoxb2-cre)1Ksec,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Lbx1-cre)3Cbm,
Tg(Mef2c-cre)2Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Mpz-cre)94Imeg,
Tg(MYOD1-cre)M23Glh,
Tg(Nes-cre)1Atp,
Tg(Pax3-cre)1Joe,
Tg(Prrx1-cre)1Cjt,
Tg(Sim1-cre)1Lowl,
Tg(Smad7-cre)1Sjc,
Tg(Sox10-cre)1Wdr,
Tg(Sox10-cre)507Mcln,
Tg(Tagln-cre)1Her,
Tg(Tbx18-icre)1Fech,
Tg(Tbx1-cre)1Joe,
Tg(Thy1-cre)1Vln,
Tg(Tyr-cre)1Gfk,
Tg(Ure2-cre)1Jlr,
Tg(Wnt1-cre)11Rth,
Tg(Wnt1-cre/ERT)1Alj,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor
(less)
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Images
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J:88829
Fig. 2
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools