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Allele Information
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Allele:
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Inducer:
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induced by tamoxifen
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Synonym:
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Tg(CAG-cre/Esr1)1Lbe, pCX-CreERTM, beta-actin-CreER, CX-CreERx, actin-creER, Tg(ACTB-cre/Esr1)1Lbe
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Molecular description:
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This transgenic construct was generated by ligating sequence encoding a fusion protein of cre recombinase and a mutant mouse estrogen receptor ligand binding domain to a CMV early enhancer and chicken beta-actin promoter. In the absence of ligand binding, the fusion protein remains in the cytoplasm. Binding of 4-hydroxytamoxifen enables the fusion protein to move to nucleus where it may act upon DNA. This transgenic line was generated by electroporating the contstruct into ES cells. Expression of the fusion protein was in a widespread mosaic pattern. Two lines were generated, BD8 with two copies of the transgene and CA6 with one copy.
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Find mice (IMSR):
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Mouse Strains:
0 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(CAG-cre/Esr1*)1Lbe activity also observed in:
alimentary system,
cardiovascular system,
embryo-other,
endocrine system,
integumental system,
liver and biliary system,
muscle,
nervous system,
renal and urinary system,
reproductive system,
respiratory system,
sensory organs
(less)
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Tissue Information
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Limbs
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Other recombinase alleles with activity in Limbs tissues:
Acantm1(cre/ERT2)Crm,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Fgf16tm1.1(cre)Sms,
Foxg1tm1(cre)Skm,
Gli1tm3(cre/ERT2)Alj,
Gt(ROSA)26Sortm1(FLP1)Dym,
HhatTg(TFAP2A-cre)1Will,
Lmx1btm2(cre/ERT2)Rjo,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myocdtm1(cre)Jomm,
Myod1tm2.1(icre)Glh,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Osr2tm2(cre)Jian,
Pax3tm1(cre)Joe,
Shhtm1(EGFP/cre)Cjt,
Shhtm2(cre/ERT2)Cjt,
Six1tm1(cre,ALPP)Xli,
Tg(ACTA1-cre)1Mll,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-cre/ERT2)97.16Mtz,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(Col10a1-cre)1427Vdm,
Tg(Col10a1-cre)1Xya,
Tg(Col11a2-cre)4Nhzi,
Tg(Col1a1-cre)1Bek,
Tg(Col1a1-cre)1Kry,
Tg(Col1a1-cre)2Bek,
Tg(Col1a1-cre/ERT2)1Crm,
Tg(Col1a1-cre/Esr1*)1Mis,
Tg(Col1a1-cre)#Xya,
Tg(Col1a2-cre)23Angl,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(Col2a1-cre)1Rsjo,
Tg(Col2a1-cre)1Xya,
Tg(Col2a1-cre)3Amc,
Tg(Col2a1-cre/ERT)1Flng,
Tg(Col2a1-cre/ERT2)1Dic,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Col2a1-rtTA,tetO-cre)22Pjro,
Tg(Dll1-cre)33Dchp,
Tg(dlx6a-cre)1Mekk,
Tg(Dmp1-cre)1Jqfe,
Tg(EIIa-cre)C5379Lmgd,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Frzb-cre)1Tylz,
Tg(Gh1-cre)1Sac,
Tg(Ghrhr-cre)3242Lsk,
Tg(Hand2-cre)7-1Clou,
Tg(Hoxb2-cre)1Ksec,
Tg(Hoxb6-cre)A5Mku,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre/ERT)1Smac,
Tg(Hspa2-cre)1Eddy,
Tg(I12b-cre)1Jlr,
Tg(KRT14-cre)1Amc,
Tg(KRT1-5-cre)5132Jlj,
Tg(Lbx1-cre)3Cbm,
Tg(Mef2c-cre)1Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Msx2-cre)5Rem,
Tg(Msx2-cre/ERT)27Alj,
Tg(Myh7-cre)1Zli,
Tg(Myl1-cre)13Nros,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Osr1-cre)4Mrt,
Tg(Pax3-cre)2Joe,
Tg(Pf4-cre)Q3Rsko,
Tg(Pitx3-cre/ERT2)1Ydq,
Tg(Pou3f4-cre)32Cren,
Tg(POU3F4-cre)M51Cren,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-cre/ERT2)1Mlgn,
Tg(Rarb-cre)1Bhr,
Tg(Rarb-cre)1Mrc,
Tg(Runx2-icre)1Jtuc,
Tg(S100b-EGFP/cre/ERT2)22Amc,
Tg(Scx-cre)HShuk,
Tg(Scx-cre)LShuk,
Tg(Sim1-cre)1Lowl,
Tg(Smad7-cre)1Sjc,
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)1Fech,
Tg(T-cre)1Lwd,
Tg(Thy1-cre)1Vln,
Tg(Ure2-cre)1Jlr,
Tg(Wnt1-cre)11Rth,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor
(less)
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Images
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J:81562
Fig. 6
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools