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Gt(ROSA)26Sortm1(cre/ERT)Nat - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm1(cre/ERT)Nat
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans 		Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: CreERT1, Gt(ROSA)26Sortm1(cre/Esr1)Nat, R26CreER, R26ERCre, R26RNatCre
Molecular description: A cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen.
Find mice (IMSR): Mouse Strains: 3 strains available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1(cre/ERT)Nat activity also observed in:
head, reproductive system, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:155417 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 188 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory