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Tg(Plp1-cre/ERT2)1Ueli - Integumental System
Recombinase Activity Detail
Allele Information
transgene insertion 1, Ueli Suter
Driver: Plp1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: PLP-CreERT2, PLP/Cre-ERT2, Tg(Plp1-cre/ESR1)1Ueli
Molecular description: The transgene consists of a mouse Plp promoter region (exons 1 and 2) and a cre-ESR1 cassette. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. 15 kb of mouse Plp promoter sequences drive transgene expression in oligodenrocytes and Schwann cells.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Plp1-cre/ERT2)1Ueli activity also observed in:
nervous system, sensory organs
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory