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Tg(Tagln-cre)1Her - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tagln-cre)1Her
transgene insertion 1, Joachim Herz
Driver: Tagln
Type: Transgenic (Recombinase)
Synonym: SM, SM22a-Cre, Sm22alphaCre, SM22-Cre, SM22-Cretg, Tag1-Cre, Tgln-Cre
Molecular description: The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tagln-cre)1Her activity also observed in:
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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Fig. Tagln Embryo 1 E10.5
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Fig. Tagln Embryo 1 E15.5
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Fig. Tagln Embryo 2 E10.5
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Fig. Tagln Heart P56
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Fig. Tagln Heart P7
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Fig. Tagln Liver P7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 90 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory