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Gt(ROSA)26Sortm1(cre/ERT)Brn - Integumental System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm1(cre/ERT)Brn
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Anton Berns 		Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: ACM-cre, Cre-ERTm, Gt(ROSA)26Sortm1(cre/Esr1)Brn, R26cre-ERT, R26-CreERT, R26Cre-ERT, Tx-Cre
Molecular description: The endogenous locus was modified by insertion of a construct containing the rabbit beta-globin 3' splice site followed by the cre/ERT fusion gene, which encodes Cre recombinase joined to the G321R mutant hormone-binding domain of the human estrogen receptor that is activated by 4-hydroxytamoxifen (4-OHT), but not by the natural ER ligand 17-beta-estradiol. The fusion gene is followed by the rabbit beta-globin polyadenylation signal and a PGK-puro (puromycin resistance) cassette. Efficient Cre-mediated recombination in transgenic mice carrying floxed reporter genes was reported to reflect constitutive expression of the Gt(ROSA)26Sor from preimplantation stages onward.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1(cre/ERT)Brn activity also observed in:
alimentary system, cavities & their linings, liver & biliary system, renal & urinary system, respiratory system
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 70 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory