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Taglntm1(cre/ERT2)Feil - Cardiovascular System
Recombinase Activity Detail
Allele Information
transgelin; targeted mutation 1, Robert Feil
Driver: Tagln
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: SM22alphaCew-ERT2, SM-Cre ERT2(ki), SM-CreERT2(ki), SM-CreERT2(ki), Taglntm1(cre/ESR1)Feil
Molecular description: An allele encoding a tissue specific and ligand dependent recombinase was generated by inserting cre recombinase/modified estrogen receptor (ESR1) fusion sequence into the endogenous allele. The ESR1 sequence contained engineered missense mutations at positions 400, 543, 540 which substituted the ability to bind the endogenous ligand with the ability to bind tamoxifen (J:79835). Histochemical analysis of mutant mice treated with tamoxifen showed expression of cre in smooth muscle tissue.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Taglntm1(cre/ERT2)Feil activity also observed in:
alimentary system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
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J:69325 Fig. 3 J:69325 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory