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Tg(Nes-cre)1Wme - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nes-cre)1Wme
transgene insertion 1, Werner Muller
Driver: Nes
Type: Transgenic (Recombinase)
Synonym: bal1, Bal1 cre, balancer1, Nestin-Cre, SLNE4c, Tg(balancer1)2Cgn, TgN(balancer1)1Cgn, TgN(balancer1)2Cgn
Molecular description: The transgenic construct contained a nestin promoter followed by cre recombinase sequence adjoined to a nuclear localization signal. Intron 2 of the nestin gene was included upstream of a polyadenylation signal. While the endogenous nestin promoter is CNS-specific, Southern blot analysis showed the ubiquitous expression of cre in transgenic mice. Variable mosaicism/partial deletion of loxP-flanked alleles occurs before embryonic day 10.5, and it is detectable in all adult organs examined including germ line cells.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nes-cre)1Wme activity also observed in:
early embryo, embryo-other
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:75055 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory