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Tg(CAG-cre/Esr1*)5Amc - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(CAG-cre/Esr1*)5Amc
transgene insertion 5, Andrew P McMahon 		Driver: CAG
Type: Transgenic (Cre/Flp)
Inducer: Induced by tamoxifen.
Synonym: ER-cre, TgCAGGCreER, CAGGCre-ERTM, Cre-ER, CreESRT, CAGG-Cre, CAGGS-CreER, CAGGCre-ERtm line 5.8, CAGG-CreERT2, Cre-ERTM, TgCreER, CAGGS-CreErT, CAGGCre-ER, uCreERT, Tg(cre/Esr1)5Amc, CAGGS-CreER, CMV-creERT, Tg(cre/Esr1)5Amc, Tg(CAG-cre/Esr1)5Amc, CAG-CreERT2, CaggCreER
Molecular description: This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where cre can excise loxP-flanked segments from conditionally modified genes.
Find mice (IMSR): Mouse Strains: 6 lines available       Cell Lines: 0 lines available
Additional Tissues: Tg(CAG-cre/Esr1*)5Amc activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:76130
Fig. 3 J:76130
Fig. 6 J:76130
Fig. 7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 199 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory