About   Help   FAQ
Tg(CAG-cre/Esr1*)5Amc - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(CAG-cre/Esr1*)5Amc
transgene insertion 5, Andrew P McMahon
Driver: CAG
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: CAG-CreEr, CAGG-Cre, CaggCreER, CAGGCre-ER, CAGGCre-ERTM, CAGGCre-ERtm line 5.8, CAGGS-CreER, CAGGS-CreErT, CMV-creERT, Cre-ER, Cre-ERTM, CreESRT, ER-cre, Tg:Cag-Cre/Esr1, Tg(CAG-cre/Esr1)5Amc, TgCAGGCreER, TgCreER, Tg(cre/Esr1)5Amc, uCreERT
Molecular description: This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where cre can excise loxP-flanked segments from conditionally modified genes.
Find mice (IMSR): Mouse Strains: 9 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(CAG-cre/Esr1*)5Amc activity also observed in:
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:216865 Full Image
Fig. CAG Adult CB
J:216865 Full Image
Fig. CAG Adult choroid plexus
J:216865 Full Image
Fig. CAG Adult CX hypo hipp thal
J:216865 Full Image
Fig. CAG Adult eye
J:216865 Full Image
Fig. CAG Adult midbrain
J:216865 Full Image
Fig. CAG Adult OB
J:216865 Full Image
Fig. CAG Adult pons medulla
J:260776 Full Image
Fig. CAG E10.5 brachialarches
J:260776 Full Image
Fig. CAG E10.5 diencephalon
J:260776 Full Image
Fig. CAG E10.5 eye
J:260776 Full Image
Fig. CAG E10.5 frontonasal
J:260776 Full Image
Fig. CAG E10.5 hindbrain
J:260776 Full Image
Fig. CAG E10.5 mesenchyme_head
J:260776 Full Image
Fig. CAG E10.5 midbrain
J:260776 Full Image
Fig. CAG E10.5 opticstalk
J:260776 Full Image
Fig. CAG E10.5 otocyst
J:260776 Full Image
Fig. CAG E10.5 telencephalon
J:260776 Full Image
Fig. CAG E15.5 chondrocranium
J:260776 Full Image
Fig. CAG E15.5 cortex
J:260776 Full Image
Fig. CAG E15.5 diencephalon
J:260776 Full Image
Fig. CAG E15.5 ear
J:260776 Full image
Fig. CAG E15.5 eye
J:260776 Full Image
Fig. CAG E15.5 lowerjaw
J:260776 Full Image
Fig. CAG E15.5 medulla
J:260776 Full Image
Fig. CAG E15.5 mesenchyme_head
J:260776 Full Image
Fig. CAG E15.5 midbrain
J:260776 Full Image
Fig. CAG E15.5 nose
J:260776 Full Image
Fig. CAG E15.5 palateshelf
J:260776 Full Image
Fig. CAG E15.5 upperjaw
J:76130 Fig. 2 J:76130 Fig. 3 J:76130 Fig. 6
J:76130 Fig. 7
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 738 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory