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Allele Information
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Allele:
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Hprttm1(cre)Mnn
hypoxanthine guanine phosphoribosyl transferase;
targeted mutation 1, Jeffrey R Mann
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Driver: CAG
Type: Targeted (knock-in)
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Synonym:
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Hprttm1(CAG.cre)MdCoh, Hprt1tm1(cre)Mnn, Hprtcre, hprt-cre
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Molecular description:
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An expression cassette in which a CMV enhancer and chicken beta-globin promoter driving Cre recombinase expression was inserted in reverse transcriptional orientation into exon 3 of the gene. A PGK-neomycin selection cassette was also inserted following the cre gene. Expression of Cre recombinase occurred at high levels in the female germline and fertilized eggs, and all offspring of heterozyous females display excision of reporter sequences.
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Find mice (IMSR):
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Mouse Strains:
1 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Hprttm1(cre)Mnn activity also observed in:
alimentary system,
cardiovascular system,
embryo-other,
endocrine system,
hemolymphoid system,
liver and biliary system,
muscle,
nervous system,
postnatal-other,
renal and urinary system,
reproductive system,
respiratory system
(less)
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Tissue Information
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Integumental System
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Other recombinase alleles with activity in Integumental System tissues:
Airetm3(cre)Mmat,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Chattm1(cre)Lowl,
Cldn6tm1(cre/ERT2)Dam,
Corintm2(cre)Bamo,
Dcttm1(cre)Bee,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Gad2tm2(cre)Zjh,
Grhl3tm1(cre)Cgh,
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn,
Gt(ROSA)26Sortm1(cre/ERT)Brn,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
HhatTg(TFAP2A-cre)1Will,
Hsd11b2tm1(cre)Anft,
Krt14tm1.1(cre)Wbm,
Krt14tm1(cre)Wbm,
Lgr5tm1(cre/ERT2)Cle,
Mcm2tm1(cre/ERT2)Scpr,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre)Mrc,
Myf5tm3(cre)Sor,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Omptm4(cre)Mom,
Pax3tm1(cre)Joe,
Shhtm1(EGFP/cre)Cjt,
Tg(Adipoq-cre)1Evdr,
Tg(Aire-cre)410-5Mmat,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(Camk2a-cre)1Nobs,
Tg(CD2-cre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CMV-cre)1Cgn,
Tg(CMV-cre/ERT)1Ipc,
Tg(Col10a1-cre)1Xya,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT)7Cpd,
Tg(COL2A1-cre)1Wag,
Tg(Col6a1-cre)1Gkl,
Tg(Cryaa-cre)10Mlr,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp19a1-cre)5912Gle,
Tg(Ddx4-cre)1Dcas,
Tg(dlx6a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Fabp4-cre)1Abel,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(GFAP-cre)25Mes,
Tg(Ghrhr-cre)3242Lsk,
Tg(Grik4-cre)G32-4Stl,
Tg(Hoxb8-cre)1403Uze,
Tg(Hspa2-cre)1Eddy,
Tg(I12b-cre)1Jlr,
Tg(Il7-cre)CRche,
Tg(Ins2-cre)25Mgn,
Tg(Itgax-cre)1-1Reiz,
Tg(Klf4-cre/ERT)1Wai,
Tg(Krt1-15-cre/PGR)22Cot,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre)1Cgn,
Tg(KRT14-cre)1Efu,
Tg(KRT14-cre)1Ipc,
Tg(KRT14-cre)43Smr,
Tg(KRT14-cre)8Brn,
Tg(KRT14-cre/ERT)20Efu,
Tg(KRT14-cre/ERT2)1Ipc,
Tg(KRT14-cre/PGR)1Der,
Tg(KRT1-5-cre)5132Jlj,
Tg(Krt1-5-cre/ERT)1Ipc,
Tg(Krt15-cre/ERT2)1Johu,
Tg(KRT18-cre/ERT2)1Rgo,
Tg(Krt2-6a-cre)1Ism,
Tg(KRT5-cre/ERT2)2Ipc,
Tg(KRT5-cre/ERT)ICmch,
Tg(KRT5-cre/ERT)SCmch,
Tg(KRT5-cre/PGR)1Der,
Tg(LGB-cre)74Acl,
Tg(Mitf-cre)710-59Gsb,
Tg(Mitf-cre)7114Gsb,
Tg(MMTV-cre)105Ayn,
Tg(MMTV-cre)1Mam,
Tg(MMTV-cre)4Mam,
Tg(MMTV-cre)7Mul,
Tg(MMTV-cre)AElee,
Tg(MMTV-cre)BElee,
Tg(MMTV-cre)#Mam,
Tg(Mpz-cre)94Imeg,
Tg(Mx1-cre)1Cgn,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Pax3-cre)1Joe,
Tg(Pax6-cre)1Zkoz,
Tg(Pax6-cre,GFP)1Pgr,
Tg(Pdgfb-icre/ERT2)1Frut,
Tg(Pf4-cre)Q3Rsko,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(Plp1-cre/ERT)3Pop,
Tg(Pou3f4-cre)32Cren,
Tg(rtetR-TetO-cre)40Mhz,
Tg(S100a4-cre)1Gle,
Tg(S100b-cre)20Ito,
Tg(Sim1-cre)1Lowl,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)1Fech,
Tg(T-cre)1Lwd,
Tg(Tek-cre/ERT2)1Soff,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tie1-cre)9Ref,
Tg(Tyr-cre)1Gfk,
Tg(Tyr-cre)1Lru,
Tg(Tyr-cre)2Lru,
Tg(Tyr-cre)3Gfk,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Tyr-cre/ERT2)1Laru,
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde,
Tg(Wap-cre)11738Mam,
Tg(Wap-cre)1Gsc,
Tg(Wap-rtTA-cre)10Whl,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt1-cre)11Rth,
Tg(WT1-cre)1Asc,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor
(less)
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Images
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J:147304
Fig. 2
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools