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Tg(GFAP-cre)25Mes - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(GFAP-cre)25Mes
transgene insertion 25, Albee Messing 		Driver: GFAP
Type: Transgenic (Cre/Flp)
Synonym: hGFAP-cre, Gfa2-Cre, GFAP-Cre-m, Tg95.2, TgN25Mes, hGFAPcre, hGFAP::Cre, TgN(GFAPcre)25Mes, GFAP-Cre
Molecular description: This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase.
Find mice (IMSR): Mouse Strains: 1 lines available       Cell Lines: 0 lines available
Additional Tissues: Tg(GFAP-cre)25Mes activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:184578
Fig. GFAP Brain Adult J:184578
Fig. GFAP Brain aP7 J:184578
Fig. GFAP Brain bP7 J:184578
Fig. GFAP Embryo a E10.5 J:184578
Fig. GFAP Embryo a E15.5 J:184578
Fig. GFAP Embryo b E10.5 J:184578
Fig. GFAP Embryo b E15.5 J:184578
Fig. GFAP Nerve Adult
J:184578
Fig. GFAP Sp Cord P7 J:72509
Fig. 2 J:72509
Fig. 3 J:72509
Fig. 5 J:72509
Fig. 6 J:72509
Fig. 7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 122 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory