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Allele Information
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Allele:
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Tg(GFAP-cre)25Mes
transgene insertion 25, Albee Messing
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Driver: GFAP
Type: Transgenic (Cre/Flp)
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Synonym:
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hGFAP::Cre, GFAP-Cre-m, hGFAPcre, TgN25Mes, TgN(GFAPcre)25Mes, Tg95.2, GFAP-Cre, hGFAP-cre, Gfa2-Cre
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Molecular description:
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This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase.
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Find mice (IMSR):
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Mouse Strains:
1 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(GFAP-cre)25Mes activity also observed in:
adipose tissue,
branchial arches,
cardiovascular system,
endocrine system,
hemolymphoid system,
integumental system,
liver and biliary system,
nervous system,
postnatal-other,
renal and urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system,
tail
(less)
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Tissue Information
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Alimentary System
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Other recombinase alleles with activity in Alimentary System tissues:
1700009P17Riktm1.1(icre)Heli,
Airetm3(cre)Mmat,
Ascl3tm1(EGFP/cre)Ovi,
Atoh1tm1(cre)Gan,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Chattm1(cre)Lowl,
Cldn6tm1(cre/ERT2)Dam,
Cpa1tm1(cre/ERT2)Dam,
Crhtm1(cre)Zjh,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Fgf16tm1.1(cre)Sms,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxg1tm1(cre)Skm,
Foxn1tm3(cre)Nrm,
Gad2tm2(cre)Zjh,
Grhl3tm1(cre)Cgh,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(cre/ERT)Brn,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
HhatTg(TFAP2A-cre)1Will,
Hnf4atm1(cre)Sdv,
Hprttm1(cre)Mnn,
Hsd11b2tm1(cre)Anft,
Krt19tm1(cre/ERT)Ggu,
Krt19tm1(cre)Mmt,
Lgr5tm1(cre/ERT2)Cle,
Lyz2tm1(cre)Ifo,
Mcm2tm1(cre/ERT2)Scpr,
Mnx1tm4(cre)Tmj,
Myf5tm3(cre)Sor,
Ncr1tm1.1(icre)Viv,
Nkx2-5tm1(cre)Rjs,
Nkx2-5tm2(cre)Rph,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Omptm4(cre)Mom,
Osr2tm2(cre)Jian,
Pax3tm1(cre)Joe,
Plekha5Tg(AMH-cre)1Flor,
Ptf1atm1.1(cre)Cvw,
Runx1tm1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Six1tm1(cre,ALPP)Xli,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Ssttm2.1(cre)Zjh,
Taglntm1(cre/ERT2)Feil,
Taglntm2(cre)Yec,
Tg(Acp5-cre)3Rda,
Tg(Acp5-cre)4Rda,
Tg(Acta2-cre/ERT2)12Pcn,
Tg(Acta2-cre/ERT2)51Pcn,
Tg(ACTC1-cre)1Miwa,
Tg(Acvrl1-cre)L1Spo,
Tg(Adipoq-cre)1Evdr,
Tg(Aire-cre)410-5Mmat,
Tg(Alb1-cre)1Dlr,
Tg(Amy2-cre)1Herr,
Tg(Atp4b-cre)1Jig,
Tg(Atp4b-cre)3Xya,
Tg(ATP6V1B1-cre)45Rnel,
Tg(Avil-cre)1Phep,
Tg(CA2-cre)1Subw,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CAG-cre/Esr1*)86Lbgn,
Tg(Capn8-cre)1Xya,
Tg(Car1-cre)5Flt,
Tg(CD2-cre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(CDX2-cre*)189Erf,
Tg(Chst4-cre)1Hkwa,
Tg(Cma1-cre)6Thhe,
Tg(CMV-cre)1Cgn,
Tg(Col1a1-cre/ERT2)1Crm,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT)7Cpd,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(Col6a1-cre)1Gkl,
Tg(Csf1r-icre)1Jwp,
Tg(Ctsk-cre)1Rda,
Tg(Ctsk-cre)8Rda,
Tg(Cyp1a1-cre)1Dwi,
Tg(Cyp1a1-cre/ERT)1Dwi,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(Dbh-icre)1Gsc,
Tg(Dll1-cre)33Dchp,
Tg(dlx6a-cre)1Mekk,
Tg(Dmp1-cre)1Jqfe,
Tg(Dspp-cre)1Kul,
Tg(ED-L2-cre)267Jkat,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)2Lfp,
Tg(Fabp1-cre)1Jig,
Tg(Fabp1-cre-GH1)1Jig,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Foxa2*-cre)#Mku,
Tg(Foxa3-cre)1Khk,
Tg(Foxl1-cre)1Khk,
Tg(Gcg-cre)1Herr,
Tg(GFAP-cre/Esr1*,-lacZ)ASbk,
Tg(GFAP-cre/Esr1*,-lacZ)BSbk,
Tg(Grik4-cre)G32-4Stl,
Tg(GZMB-cre)1Jcb,
Tg(Hand2-cre)7-1Clou,
Tg(Hhex-cre,-GFP)1Ksz,
Tg(Hoxa1-cre)1Tlu,
Tg(Hoxb3-cre)1Pkht,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Il7-cre)CRche,
Tg(Ins2-cre)23Herr,
Tg(Ins2-cre)25Mgn,
Tg(INS-icre)18Msdr,
Tg(Itgax-cre)1-1Reiz,
Tg(Kdr-cre)15962Brei,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre)1Cgn,
Tg(KRT14-cre)1Efu,
Tg(KRT14-cre)1Ipc,
Tg(KRT14-cre)43Smr,
Tg(KRT14-cre)8Brn,
Tg(KRT1-5-cre)5132Jlj,
Tg(Krt2-6a-cre)1Ism,
Tg(KRT5-cre/ERT)ICmch,
Tg(KRT5-cre/ERT)SCmch,
Tg(mI56i-cre)6-2Clou,
Tg(MMTV-cre)1Mam,
Tg(MMTV-cre)4Mam,
Tg(Mpz-cre)94Imeg,
Tg(Mx1-cre)1Cgn,
Tg(Mx1-cre)29-4Her,
Tg(Myh11-cre)5013Gko,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-cre/ERT2)1Soff,
Tg(MYOD1-cre)M23Glh,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nes-cre/ERT2)73Lfp,
Tg(Neurog3-cre)1Dam,
Tg(NEUROG3-cre)1Herr,
Tg(Neurog3-cre)C1Able,
Tg(Neurog3-cre/Esr1*)1Dam,
Tg(Nkx2-1-cre)2Sand,
Tg(Nkx2-5-cre)9Eno,
Tg(Osr1-cre)4Mrt,
Tg(Pax6-cre)1Rilm,
Tg(Pax6-cre,GFP)1Pgr,
Tg(Pdgfb-icre/ERT2)1Frut,
Tg(Pdx1-cre)1Herr,
Tg(Pdx1-cre)6Cvw,
Tg(Pf4-cre)Q3Rsko,
Tg(Pitx3-cre/ERT2)1Ydq,
Tg(Plp1-cre/ERT)3Pop,
Tg(rtetR-TetO-cre)40Mhz,
Tg(S100a4-cre)1Egn,
Tg(Sftpa1-cre)1Xya,
Tg(Sim1-cre)1Lowl,
Tg(Smad7-cre)1Sjc,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tal1-cre/ERT)42-056Jrg,
Tg(T-cre)1Lwd,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre/ERT2)1Arnd,
Tg(tetO-cre)1Jaw,
Tg(tetO-cre)3Jig,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tlx2-cre)#Mori,
Tg(Tnni3-cre/GFP)1Mknn,
Tg(TPO-cre)1Shk,
Tg(Tyr-cre)1Gfk,
Tg(Tyrp1-cre)1Ipc,
Tg(Ure2-cre)1Jlr,
Tg(Vav1-cre)8Cgp,
Tg(Vav1-cre)A2Kio,
Tg(Vil-cre)1Mka,
Tg(Vil-cre)20Syr,
Tg(Vil-cre)997Gum,
Tg(Vil-cre/ERT2)23Syr,
Tg(Wap-cre)11738Mam,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt1-cre)11Rth,
Tg(WT1-cre)AG11Dbdr,
Thtm1(cre)Te,
Twist2tm1.1(cre)Dor,
Viptm1(cre)Zjh
(less)
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Images
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J:184578
Fig. GFAP Embryo a E15.5
J:184578
Fig. GFAP Embryo b E15.5
J:184578
Fig. GFAP Intestine P7
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools