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Tg(Nes-cre)1Atp - Mesenchyme
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nes-cre)1Atp
transgene insertion 1, Andreas Trumpp
Driver: Nes
Type: Transgenic (Recombinase)
Synonym: Nes-Cre1, Nestincre, Nestin-Cre, Tg(Nes-cre)1Mrt
Molecular description: The 5' region of the rat nestin gene was placed upstream of an NLS-Cre-pA and the rat nestin intron 2. This line carried a single or low copy transgene. The absence of transcript expression was confirmed by RT-PCR on endoneurial extracts. This promoter is active by E9 in the CNS progenitor cells. Transgene is paternally imprinted, thus brain-specific recombination is only 30% when allele is maternally inherited, compared to ~95% with paternal transmission (J:75417, J:121563).
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nes-cre)1Atp activity also observed in:
Tissue Information
Mesenchyme Other recombinase alleles with activity in Mesenchyme tissues:
Images
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J:111945 Fig. 2 J:111945 Fig. 3 J:111945 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 56 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory