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Allele Information
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Allele:
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Tg(Nes-cre)1Atp
transgene insertion 1, Andreas Trumpp
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Driver: Nes
Type: Transgenic (Cre/Flp)
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Synonym:
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Tg(Nes-cre)1Mrt, Nestin-Cre, Nes-Cre1, Nestincre
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Molecular description:
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The 5' region of the rat nestin gene was placed upstream of an NLS-Cre-pA and the rat nestin intron 2. This line carried a single or low copy transgene. The absence of transcript expression was confirmed by RT-PCR on endoneurial extracts. This promoter is active by E9 in the CNS progenitor cells. Transgene is paternally imprinted, thus brain-specific recombination is only 30% when allele is maternally inherited, compared to ~95% with paternal transmission (J:75417, J:121563).
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Find mice (IMSR):
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Mouse Strains:
0 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(Nes-cre)1Atp activity also observed in:
alimentary system,
branchial arches,
cardiovascular system,
cavities and their linings,
extraembryonic component,
head,
hemolymphoid system,
integumental system,
liver and biliary system,
mesenchyme,
nervous system,
renal and urinary system,
respiratory system,
sensory organs,
skeletal system
(less)
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Tissue Information
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Embryo-other
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Other recombinase alleles with activity in Embryo-other tissues:
1700009P17Riktm1.1(icre)Heli,
Acantm1(cre/ERT2)Crm,
Alpltm1(cre)Nagy,
Bmpr1bTg(ACTB-FLP)4917Dym,
Calb2tm1(cre)Zjh,
Cldn6tm1(cre/ERT2)Dam,
Fgf16tm1.1(cre)Sms,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxg1tm1(cre)Skm,
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn,
Gt(ROSA)26Sortm1(FLP1)Dym,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm3(phiC31*)Sor,
Gt(ROSA)26Sortm5(phiC31)Sor,
HhatTg(TFAP2A-cre)1Will,
Hoxa3tm1(cre)Moon,
Hprttm10(Ple162-EGFP/cre)Ems,
Hprttm1(cre)Mnn,
Kdrtm1(cre)Sato,
Krt19tm1(cre)Mmt,
Mapttm1(cre)Nagy,
Meox2tm1(cre)Sor,
Mesp1tm2(cre)Ysa,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myf6tm1(cre)Mrc,
Myf6tm2(cre)Mrc,
Myocdtm1(cre)Jomm,
Myod1tm2.1(icre)Glh,
Nkx2-5tm1(cre)Rjs,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Osr1tm1(EGFP/cre/ERT2)Amc,
Osr2tm2(cre)Jian,
Pax3tm1(cre)Joe,
Pax7tm1(cre)Mrc,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Six1tm1(cre,ALPP)Xli,
Sox17tm2.1(icre)Heli,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tfap2atm1(cre)Moon,
Tg(ACTA1-cre)1Mll,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(ACTB-cre)2Mrt,
Tg(ACTC1-cre)1Miwa,
Tg(ACTFLPe)9205Dym,
Tg(Acvrl1-cre)B1Spo,
Tg(Acvrl1-cre)L1Spo,
Tg(CAG-cre)13Miya,
Tg(CAG-cre)1Nagy,
Tg(CAG-cre)2Osb,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CAG-dre)1Afst,
Tg(CAG-Flpo)1Afst,
Tg(Camk2a-cre)1Nobs,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(Cdx1-cre)23Kem,
Tg(CDX2-cre)101Erf,
Tg(Cga-cre)3Sac,
Tg(CMV-cre)1And,
Tg(CMV-cre)1Cgn,
Tg(Col10a1-cre)1Xya,
Tg(Col11a2-cre)4Nhzi,
Tg(Col1a1-cre)1Kry,
Tg(Col1a1-cre/Esr1*)1Mis,
Tg(Col1a1-cre)#Xya,
Tg(Col1a2-cre)23Angl,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(Col2a1-cre)1Rsjo,
Tg(COL2A1-cre)1Wag,
Tg(Col2a1-cre)3Amc,
Tg(Col2a1-cre/ERT)1Flng,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Col2a1-rtTA,tetO-cre)22Pjro,
Tg(Cryaa-cre)39Mlr,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp19a1-cre)5912Gle,
Tg(Dct-cre)1Apdn,
Tg(Dll1-cre)33Dchp,
Tg(dlx6a-cre)1Mekk,
Tg(DMRT1-cre)1Svs,
Tg(EIIa-cre)C5379Lmgd,
Tg(Emx1-cre)3Ito,
Tgfb3tm1(cre)Vk,
Tg(Fgf15-cre)1Bld,
Tg(Fgf15/Hsp68-cre)1Bld,
Tg(Foxa2*-cre)#Mku,
Tg(Frzb-cre)1Tylz,
Tg(Frzb-cre)2Tylz,
Tg(Frzb-cre)3Tylz,
Tg(Fzd10-cre/Esr1*)1Chzh,
Tg(Gata1-cre)1Sho,
Tg(GATA5-cre)1Krc,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand2-cre)7-1Clou,
Tg(HBB-cre)12Kpe,
Tg(HBB-cre)27038Kpe,
Tg(HBB-cre)27053Kpe,
Tg(Hes7-cre)1Kag,
Tg(Hhex-cre,-GFP)1Ksz,
Tg(Hoxa1-cre)1Tlu,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre/ERT)1Smac,
Tg(Hoxb7-cre)13Amc,
Tg(Hoxb8-cre)1403Uze,
Tg(Hspa2-cre)1Eddy,
Tg(Htr1a-icre)1Fto,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kdr-cre)15962Brei,
Tg(Kera-cre)KC4.3Wwk,
Tg(Lck-cre)548Jxm,
Tg(Leftb-cre)1Hmd,
Tg(Mef2c-cre)1Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Mitf-cre)7114Gsb,
Tg(MMTV-cre)4Mam,
Tg(Mpz-cre)94Imeg,
Tg(Myh7-cre)1Zli,
Tg(Myl1-cre)13Nros,
Tg(myl2-cre)1118Tmhn,
Tg(myl2-cre)1141Tmhn,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Nes-cre)1Wme,
Tg(Neurog3-cre)C1Able,
Tg(Nodal-cre)16Hmd,
Tg(Nodal-cre)1Rob,
Tg(Nodal*-cre)#Mku,
Tg(Nppa-cre)3Vmc,
Tg(Nr5a1-cre)1Kmor,
Tg(Nr5a1-cre)2Klp,
Tg(Pax2-cre)10Shwl,
Tg(Pax2-cre)1Akg,
Tg(Pax3-cre)1Joe,
Tg(Pax3-cre)2Joe,
Tg(Pax6-cre,GFP)1Pgr,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)2Mpin,
Tg(Pitx3-cre/ERT2)1Ydq,
Tg(Pou3f4-cre)32Cren,
Tg(Prdm1-cre)1Masu,
Tg(Prrx1-cre)1Cjt,
Tg(Rarb-cre)1Bhr,
Tg(REN-cre)1Haca,
Tg(Sftpa1-cre)1Xya,
Tg(Slc17a6-icre)1Oki,
Tg(Smad7-cre)1Sjc,
Tg(Sox10-cre)1Wdr,
Tg(Sox10-cre)507Mcln,
Tg(Sox2-cre)1Amc,
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)42-056Jrg,
Tg(T-cre)1Gos,
Tg(T-cre)1Lwd,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre)#Xya,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Mori,
Tg(TSPY-cre)33aYfcl,
Tg(Tyr-cre)1Gfk,
Tg(Tyr-cre)1Lru,
Tg(Tyr-cre/ERT2)1Laru,
Tg(Tyrp1-cre)1Ipc,
Tg(Ure2-cre)1Jlr,
Tg(Vav1-cre)8Cgp,
Tg(Wnt1-cre)11Rth,
Tg(WT1-cre)1Asc,
Tg(WT1-cre)AG11Dbdr,
Tg(Zp3-cre)3Mrt,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor
(less)
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Images
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J:111945
Fig. 2
J:111945
Fig. 3
J:111945
Fig. 4
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools