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Bmpr1bTg(ACTB-FLP)4917Dym - Embryo-other
Recombinase Activity Detail
Allele Information
Allele:
Bmpr1bTg(ACTB-FLP)4917Dym
bone morphogenetic protein receptor, type 1B; transgene insertion 4917, Susan Dymecki 		Driver: ACTB
Type: Transgenic (Hypomorph, Recombinase)
Synonym: 4917Tg, ACTB:FLPe, BmprIBTg, FLPe deleter
Molecular description: A random insertion of a transgene expressing Flp recombinase under the control of a human beta-actin promoter resulted in the mutation. Exon 1 and flanking sequence are deleted and replaced with two head-to-tail copies of the transgene. RT-PCR analysis on olfactory epithelium and limb tissue of homozygous mice revealed that this mutation results in the loss of transcript expression only in the limb. The authors propose that the use of two promoters in the gene can account for the partial loss, and that the mutation affects only one of these promoters.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Embryo-other Other recombinase alleles with activity in Embryo-other tissues:
Images
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J:74965 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 65 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory