Recombinase (cre) Specificity
MGI collects and annotates expression and activity data for
recombinase-containing transgenes and knock-in alleles.
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Access Data
Find recombinases-carrying alleles
- Search for alleles assayed for specificity/expresson in a particular anatomical system.
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- Search for alleles by promoter/driver specificity.
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FAQs
- How do I...
- .. find existing recombinase-expressing transgenes and knock-ins that have a given promoter (driver)?
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- .. find the promoter (driver) that I'm looking for if it is not on the selection list?
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- .. find a recombinase-containing transgene or knock-in that is expressed in a specific tissue?
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- .. get a full list of all transgenes and knock-ins that express recombinase?
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- .. order mice with a desired recombinase construct?
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More FAQs
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Recombinase Allele Data Include
20 Nov 2009
- 279
- Recombinase-containing knock-in alleles
- 819
- Recombinase-containing transgenes
- 1,098
- Total recombinase transgenes and alleles
- 195
- Drivers in recombinase transgenes
- 331
- Drivers in recombinase knock-in alleles
- 892
- Tissues in recombinase specificity assays
More...
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Recombinase Project News
October 29, 2009
- The first edition of MGI's Recombinase Allele Project was
released October 29, 2009. Data are being curated from the
scientific literature and integrated from projects underway at collaborating
organizations. (See the Collaborators tab, below).
- MGI is part of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium.
- List of available
strains expressing cre
MGI-Mouse Recombinase (cre): About
| Cre is currently the most commonly used recombinase. It catalyzes site-specific recombination of DNA between loxP sites, thus making possible conditional mutagenesis, where specific genes can be knocked out in particular tissues and at particular developmental time points. Other recombinases, such as Flp and Dre and various inducible forms of recombinases, have been and are being developed. MGI is curating data about all recombinase-containing transgenes and knock-ins developed in mice to provide a comprehensive resource delineating known specificity patterns and allowing users to find relevant mouse resources for their studies. |
| Available data will continue to increase. To retrieve all recombinase-containing transgene and knock-in alleles, use RETRIEVE ALL ALLELES. |
| The Recombinase Specificity project at MGI is funded by NIH grants HG000330 and HD033745 and EU grant HEALTH-F4-2009-223487. |
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