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C1432 Probe Detail
Nucleotide
Probe/Clone
  • Name
    C1432
  • Sequence Type
    genomic
  • ID
    MGI:13264
  • Region Covered
    encodes exons 7-8 and 3' flank sequence
  • Parent Clone
  • Vector Type
    Plasmid
  • Insert Site
    PstI/SstI
  • Insert Size
    0.45 kb
  • Note
    Insert also exists in vector pBS.
Source
  • Species
    mouse, laboratory
  • Strain
    C57BL/6
  • Tissue
    liver
Genes
H2-Q histocompatibility 2, Q region
H2-Q4 histocompatibility 2, Q region locus 4
H2-Q6 histocompatibility 2, Q region locus 6
H2-Q8 histocompatibility 2, Q region locus 8
Polymorphisms
J:7763 Flaherty L, et al., Proc Natl Acad Sci U S A. 1985 Mar;82(5):1503-7
Endonuclease Gene Allele Fragments Strains
XbaI H2-Q a 3.7kb A, B6.K2, BALB/cFla, C57BL/6Fla, C57BL/6J, CAST/EiJ, MOLI/Ei
b absent B6.K1, BALB/cBy, BALB/cKh-H2dm2, C3H/HeJ
J:8531 O'Neill AE, et al., Immunogenetics. 1986;24(6):368-73
Notes: Because the H-2Q6 and H-2Q8 genes share many restriction sites, Southern analysis utilizing this probe and most restriction enzymes are unable to distinguish between the two loci.
Endonuclease Gene Allele Fragments Strains
BamHI H2-Q4 a 8.8kb B6.K2, C57BL/6
b 5.9kb B6.K1, BALB/cBy, BALB/cFla, CAST, MOLI, SWR/J
c 6.6kb A.SW-H2s/Sn
d absent A.CA-H2f/Sn
BamHI H2-Q6 a 5.9kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
BamHI H2-Q8 a 5.9kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
BglII H2-Q4 a 1.7kb A.SW-H2s/Sn, B6.K1, B6.K2, BALB/cBy, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn
BglII H2-Q6 a 1.7kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
BglII H2-Q8 a 1.7kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
EcoRI H2-Q4 a 9.3kb B6.AC1, B6.AC2, B6.K2, B6.K3, C57BL/6
b 14kb B6.K1, B6.K4
c absent A.CA-H2f/Sn
EcoRI H2-Q6 a 13.6kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
EcoRI H2-Q8 a 13.6kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
HindIII H2-Q4 a 10.2kb B6.K1, B6.K2, BALB/cBy, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b 9.3kb A.SW-H2s/Sn
c absent A.CA-H2f/Sn
HindIII H2-Q6 a 9.3kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
HindIII H2-Q8 a 9.3kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
TaqI H2-Q4 a 4.7kb B6.K1, B6.K2, BALB/cBy, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b 5.4kb A.SW-H2s/Sn
c absent A.CA-H2f/Sn
TaqI H2-Q6 a 2.8kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
TaqI H2-Q8 a 2.8kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
XbaI H2-Q4 a 10.6kb B6.AC1, B6.AC2, B6.K2, B6.K3, C57BL/6, MOLI
b 13.4kb B6.K1, B6.K4, BALB/cBy, BALB/cFla, CAST, SWR/J
c 3.9kb A.SW-H2s/Sn
d absent A.CA-H2f/Sn
XbaI H2-Q6 a 3.7kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
XbaI H2-Q8 a 3.7kb A.SW-H2s/Sn, B6.AC1, B6.AC2, B6.K2, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
b absent A.CA-H2f/Sn, B6.K1, B6.K4, BALB/cBy
J:557 Uehara H, et al., Mamm Genome. 1991;1(2):92-9
Notes: t haplotype and strain designations appear in the allele groupings. This polymorphism appears to be due to the insertion of a 6.0 kb IAP-like element located in or near the H-2Q4 gene in mice with the b allele.
Endonuclease Gene Allele Fragments Strains
BamHI H2-Q4 a 5.7kb C3.tw5, C3.tw120, C3H
b 6.8kb C3.t0, C3.t6, C3.t12, C3.tw1, C3.tw8, C3.tw12, C3.tw73, STOCK tw32
References
J:7763 Flaherty L, et al., Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1985 Mar;82(5):1503-7
J:8531 O'Neill AE, et al., Extensive deletions in the Q region of the mouse major histocompatibility complex. Immunogenetics. 1986;24(6):368-73
J:9093 Elliott E, et al., Novel mRNA species from a Q-subregion class-I gene of the murine major histocompatibility complex. Gene. 1987;61(2):189-98
J:557 Uehara H, et al., Molecular organization of the D-Qa region of t-haplotypes suggests that recombination is an important mechanism for generating genetic diversity of the major histocompatibility complex. Mamm Genome. 1991;1(2):92-9

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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory