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pMx34 Probe Detail
Nucleotide
Probe/Clone
  • Name
    pMx34
  • Sequence Type
    cDNA
  • ID
    MGI:12631
  • Region Covered
    encodes the Mx-1 coding region and untranslated sequences
  • Child Clone
    pSPMxS1
  • Vector Type
    Plasmid
  • Other IDs
    63004 (ATCC)
  • Synonyms
    pMx-34
Source
  • Species
    mouse, laboratory
  • Strain
    BALB.A2G-Mx1
  • Age
    embryonic
  • Tissue
    embryo
Genes
Mx1 MX dynamin-like GTPase 1
Sequences
M12279 (GenBank | EMBL | ENA | DDBJ | MGI Sequence Detail)
M21039 (GenBank | EMBL | ENA | DDBJ | MGI Sequence Detail)
Polymorphisms
J:9404 Reeves RH, et al., J Virol. 1988 Nov;62(11):4372-5
Endonuclease Gene Allele Fragments Strains
BglII Mx1 a ~7.5,~7.0,~3.9kb CZECHII, MOLD/RkJ
b ~15.0,8.0,3.9kb BALB/cJ, BALB/cPt, DW/J
c ~7.5,~7.0,~3.9kb CBA/J
EcoRI Mx1 a ~8.0,~7.0,~4.8,~2.4kb CZECHII, MOLD/RkJ
b ~8.0,~5.5,~4.0,~2.4kb BALB/cJ, BALB/cPt, DW/J
c ~8.0,~7.0,~4.8,~2.4kb CBA/J
HindIII Mx1 a ~12.0,~4.4,~3.0,~2.0kb CZECHII, MOLD/RkJ
b ~9.4,~4.4,~2.0kb BALB/cJ, BALB/cPt, DW/J
c ~4.8,~4.4,~3.0,~2.0kb CBA/J
PstI Mx1 a ~4.8,~3.5,~1.4,~0.6,~0.5 kb CZECHII, MOLD/RkJ
b ~3.5,~2.4,~1.4,~0.6,~0.5 kb BALB/cJ, BALB/cPt, DW/J
c ~4.8,~3.5,~1.4,~0.6,~0.5 kb CBA/J
J:9452 Staeheli P, et al., Mol Cell Biol. 1988 Oct;8(10):4518-23
Notes: A 2.3 BamHI fragment was isolated from this probe and used in Southern analysis. Non-Polymorphic Mx-2 bands were also detected. These are not listed here.
Endonuclease Gene Allele Fragments Strains
BamHI Mx1 a 5.6,3.2,2.5,2.0,1.0kb A2G, SL/NiA, T9 M. m. domesticus
b 5.8,3.2,2.5,1.0kb 129P3/J, A/J, ABP/LeJ, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BLKS/J, C57L/J, C58/J, DA/HuSnJ, DBA/2J, FSB/GnEiJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BlNJ, O20/A, P/J, PL/J, RF/J, RIIIS/J, SEA/GnJ, SEC/1ReJ, SF/CamEiJ, SJL/J, SK/CamEi, ST/bJ, TSI/A, TW1/A, YBR/EiJ
c 5.6,3.2,2.5,2.0,0.8kb CBA/J, CE/J, I/LnJ, PERA/EiJ
EcoRI Mx1 a multiple A2G, SL/NiA, T9 M. m. domesticus
b multiple 129P3/J, A/J, ABP/LeJ, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BLKS/J, C57L/J, C58/J, DA/HuSnJ, DBA/2J, FSB/GnEiJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BlNJ, O20/A, P/J, PL/J, RF/J, RIIIS/J, SEA/GnJ, SEC/1ReJ, SF/CamEiJ, SJL/J, SK/CamEi, ST/bJ, TSI/A, TW1/A, YBR/EiJ
c multiple CBA/J, CE/J, I/LnJ, PERA/EiJ
HindIII Mx1 a 8.0,3.8,2.5,2.4,0.6kb A2G, SL/NiA, T9 M. m. domesticus
b 8.0,3.8,2.5,0.6kb 129P3/J, A/J, ABP/LeJ, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BLKS/J, C57L/J, C58/J, DA/HuSnJ, DBA/2J, FSB/GnEiJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BlNJ, O20/A, P/J, PL/J, RF/J, RIIIS/J, SEA/GnJ, SEC/1ReJ, SF/CamEiJ, SJL/J, SK/CamEi, ST/bJ, TSI/A, TW1/A, YBR/EiJ
c 4.3,3.8,3.5,2.5,2.4kb CBA/J, CE/J, I/LnJ, PERA/EiJ
J:22777 Reeves RH, et al., Genomics. 1989 Oct;5(3):522-6
Notes: Additional common fragments are seen on Southern autoradiograms.
Endonuclease Gene Allele Fragments Strains
HindIII Mx1 b 5.9kb C57BL/6
c 6.4kb MOLD/RkJ
J:11062 Irving NG, et al., Genomics. 1991 Feb;9(2):386-9
Endonuclease Gene Allele Fragments Strains
EcoRI Mx1 b 9.0,5.5,3.6,2.6,2.2kb C57BL/10
s 9.4,4.9,3.3,2.6,2.2kb M. spretus
J:18830 Roffler-Tarlov S, et al., Neurodegeneration. 1994;3(1):61-72
Endonuclease Gene Allele Fragments Strains
BamHI Mx1 b 4.7,2.9,2.2kb C57BL/6J
s 4.4,2.7,2.1kb M. spretus
J:32823 Mariano TM, et al., Mamm Genome. 1996 Apr;7(4):321-2
Notes: A 2.3kb BamHI fragment of pMx34 was used for Southern blot analysis of Mx1
Endonuclease Gene Allele Fragments Strains
XbaI Mx1 m not given M. m. musculus
n not given C58/J, NFS/N
References
J:8132 Staeheli P, et al., Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell. 1986 Jan 17;44(1):147-58
J:9404 Reeves RH, et al., Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21. J Virol. 1988 Nov;62(11):4372-5
J:9452 Staeheli P, et al., Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol. 1988 Oct;8(10):4518-23
J:22777 Reeves RH, et al., The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. Genomics. 1989 Oct;5(3):522-6
J:11062 Irving NG, et al., The multipoint genetic mapping of mouse chromosome 16. Genomics. 1991 Feb;9(2):386-9
J:3226 Johnson KR, et al., Genetic mapping of the murine gene and 14 related sequences encoding chromosomal protein HMG-14. Mamm Genome. 1992;3(11):625-32
J:18830 Roffler-Tarlov S, et al., The chromosomal location of the murine mutation weaver. Neurodegeneration. 1994;3(1):61-72
J:32823 Mariano TM, et al., Genetic mapping of the gene for the mouse interferon-gamma receptor signaling subunit to the distal end of chromosome 16. Mamm Genome. 1996 Apr;7(4):321-2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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