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pH-2IIa Probe Detail
Nucleotide
Probe/Clone
  • Name
    pH-2IIa
  • Sequence Type
    cDNA
  • ID
    MGI:12067
  • Region Covered
    encodes a 3' portion of the coding region and 3'-untranslated region
  • Parent Clone
  • Vector Type
    Plasmid
  • Insert Size
    ~680bp
  • Synonyms
    pH2IIa
Source
  • Species
    mouse, laboratory
  • Strain
    BALB/c
  • Tissue
    lymphocyte
  • Cell Line
    lymphoma cell line C14
Genes
H2 histocompatibility-2, MHC
H2-D1 histocompatibility 2, D region locus 1
H2-Q histocompatibility 2, Q region
H2-Q1 histocompatibility 2, Q region locus 1
H2-Q11 histocompatibility 2, Q region locus 11
H2-Q4 histocompatibility 2, Q region locus 4
H2-Q5 histocompatibility 2, Q region locus 5
H2-T histocompatibility 2, T region
H2-Q15 histocompatibility 2, Q region locus 15
H2-Q14 histocompatibility 2, Q region locus 14
H2-Q13 histocompatibility 2, Q region locus 13
H2-Q12 histocompatibility 2, Q region locus 12
Polymorphisms
J:11962 Steinmetz M, et al., Cell. 1981 Sep;25(3):683-92
Notes: Numerous common bands are also displayed.
Endonuclease Gene Allele Fragments Strains
BamHI H2 d 2.7kb BALB/c
k absent CBA
J:6934 Shin HS, et al., Cell. 1982 Jul;29(3):969-76
Notes: A 1.3 kb fragment encoding the 5' portion of pH-2IIa and some pBR322 sequence was isolated and used in Southern analysis. Strains and/or t haplotype designations appear in the allele groupings.
Endonuclease Gene Allele Fragments Strains
BamHI H2 a multiple BALB/c
b multiple AKR, C3H/DiSn, C57BL/6-H2k
c multiple C3.t12/t1, C3.tw12/tw32, C3H-tw2
d multiple B6.K1
e multiple B6.TL
f multiple A/J
g multiple SM/J
h multiple SWR/J
EcoRI H2 a multiple BALB/c
b multiple AKR, C3H/DiSn, C57BL/6-H2k
c multiple C3.t12/t1, C3.tw12/tw32, C3H-tw2
d multiple B6.K1
e multiple B6.TL
f multiple A/J
g multiple SM/J
h multiple SWR/J
J:7763 Flaherty L, et al., Proc Natl Acad Sci U S A. 1985 Mar;82(5):1503-7
Endonuclease Gene Allele Fragments Strains
XbaI H2-Q a multiple B6.K1
b multiple B6.K2
XbaI H2-Q a 3.7kb A, A H2-T18a, B6.K2, BALB/c-PC1, BALB/cAr, BALB/cFla, BALB/cJ, BALB/cOrnl, BALB/cWt, C57BL/6-H2-T18a, C57BL/6Fla, C57BL/6J, CAST/EiJ, DBA/2, MOLI/Ei
b absent A.CA-H2f/Sn, B6.AK1, B6.K1, BALB/cBy, BALB/cByKh, BALB/cKh-H2dm2, C3H/HeJ, C57BL/6-H2k, P/J
XbaI H2-T a multiple C57BL/6
b multiple C57BL/6-H2-T18a
J:8689 Kotzin BL, et al., J Exp Med. 1987 May 1;165(5):1237-51
Endonuclease Gene Allele Fragments Strains
PvuII H2 d - NZB
z 4.1,1.8kb NZW
J:10105 Richards S, et al., EMBO J. 1989 Dec 1;8(12):3749-57
Endonuclease Gene Allele Fragments Strains
BglII H2 c not given C3H/HeJ
r 17.0kb R4
EcoRI H2 c 5.0kb C3H/HeJ
r 7.0kb R4
HindIII H2 c not given C3H/HeJ
r not given R4
KpnI H2 c not given C3H/HeJ
r 6.0kb R4
PstI H2 c 9.0kb C3H/HeJ
r 7.0kb R4
References
J:11962 Steinmetz M, et al., A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell. 1981 Sep;25(3):683-92
J:6934 Shin HS, et al., Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes. Cell. 1982 Jul;29(3):969-76
J:7763 Flaherty L, et al., Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1985 Mar;82(5):1503-7
J:8689 Kotzin BL, et al., The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice. J Exp Med. 1987 May 1;165(5):1237-51
J:8713 Uehara H, et al., The molecular organization of the H-2K region of two t-haplotypes: implications for the evolution of genetic diversity. EMBO J. 1987 Jan;6(1):83-90
J:10105 Richards S, et al., Genetic and molecular mapping of the Hmt region of mouse. EMBO J. 1989 Dec 1;8(12):3749-57
J:13181 Wang CR, et al., Organization and structure of the H-2M4-M8 class I genes in the mouse major histocompatibility complex. Immunogenetics. 1993;38(4):258-71
J:32012 Litaker W, et al., A physical map of the Q region of B1O.P. Mamm Genome. 1996 Mar;7(3):200-5

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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory