Mouse Image NIH KOMP Gene Nomination:
prioritizing genes to be knocked out		 
KOMP-DCC    KOMP-NIH

KOMP is a trans-NIH initiative to generate a public resource of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. Both conditional and null knockouts are being generated. The purpose of this form is to gather input from the scientific community on which genes should have the highest priority for being knocked out. For more information about the NIH KOMP initiative, visit the KOMP-DCC (KOMP Data Coordination Center) or the KOMP-NIH (NIH knockout Mouse Project) sites.

Fill in Part A. and Part B. of this form to contribute your input into prioritizing genes to be knocked out by KOMP.

Read about the process by which NIH will incorporate your gene nominations and evaluate the justifications you provide for prioritizing genes to be knocked out in the KOMP project.

** IMPORTANT NOTE**
If some or all of the genes you wish to nominate as priority for being knocked out are not on the current KOMP gene list ("target" tab in the Excel file), a written justification is required for their consideration (Part B). Justifications are welcome (but not required) for prioritization of genes on the current KOMP gene list.

Helpful resources for using this form:

PART A. NOMINATE up to 10 genes that you feel should have priority for being knocked out in the KOMP project.
If you wish to nominate more than 10 genes, please submit a second form.

There are two groups funded to produce gene knockouts for the KOMP project and each uses a different strategy for creating their knockout alleles. An explanation of targeting strategies highlights the difference between constructs created by the Regeneron, Inc. project (Regeneron) and those created by the CHORI/Sanger/UC Davis project (CSD).

** Note ** all genes nominated must be present in the current list of all mouse genes.

Items preceded by an asterisk (*) must be completed for your nominations to be processed.
Each gene must have an appropriate ID; and all IDs must refer to mouse genes.
Preferred    
approach		 * Gene or allele symbol/name Nicknames or synonyms
for this gene/allele		 * Unique Identifier and Identifier Source for this gene / allele
(At least one unique identifier must be provided)
Regeneron
CSD
either
  Sample entry
  Sample entry
Sample entry showing identifiers from 2 sources
  MGI   EntrezGene
  GenBank    Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl
Regeneron
CSD
either
  MGI   EntrezGene
  GenBank   Ensembl


PART B. Once you have entered your nominations in the table above for genes that should have high priority to be knocked out, you need to determine whether a written justification is required. Written justifications will be evaluated by members of the KOMP Panel of Scientific Consultants/Advisors and NIH program officers and will remain confidential.

  • A written justification is required for any genes in your nomination list that are not in the current KOMP gene list ("target" tab in the Excel file). The justification document is limited to 1 page in length.
  • Justifications are welcome (but not required) for those genes that are in the current KOMP gene list.
** Note ** all genes nominated must be present in the current list of all mouse genes.

Relevant Information to include in your justification document might be (but is not limited to):

  • reason for wanting a new knockout allele where one has previously been made (e.g., hypomorphic allele, no reporter included, no conditional allele, less desirable strain background)
  • scientific justification for a pathway or gene family that gives this gene group high priority
  • relevance to human health or human disease
  • information about known phenotypes associated with this gene(s)
  • key publications on this gene or mutants of this gene
  • size, composition and evidence of interest in this gene by the research community where this knockout is needed

Submit your written justification for these nominations. Please submit your document in .PDF format.

Upload my PDF file.      File path (Get help with uploading your file)

If you are unfamiliar with converting a document to .PDF format, consult the help documentation for your word processor or send e-mail to mgi-help@informatics.jax.org.

Contact Details:

** All fields must be completed **

Last name:
First name (& initial):
E-mail address:
Laboratory PI:
Institute/Organization:
Address line 1:
           line 2 (if needed):
City:
State/Province:
Postal code:
Country:
Telephone:
Fax:


My laboratory's funding source(s)
(check ALL that apply):


NCRR, National Center for Research Resources
NEI, National Eye Institute
NHGRI, National Human Genome Research Institute
NHLBI, National Heart, Lung and Blood Institute
NIA, National Institute on Aging
NIAAA, National Institute of Alcohol Abuse and Alcoholism
NIAID, National Institute of Allergy and Infectious Disease
NIAMS, National Institute of Arthritis and Musculoskeletal and Skin Diseases
NICHD, National Institute of Child Health and Human Development
NIDCD, National Institute on Deafness and Other Communication Disorders
NIDCR, National Institute of Dental and Craniofacial Research
NIDA, National Institute on Drug Abuse
NIEHS, National Institute of Environmental Health Sciences
NIGMS, National Institute of General Medical Sciences
NIMH, National Institute of Mental Health
NINDS, National Institute of Neurological Disorders and Stroke
NIDDK, National Institute of Diabetes and Digestive and Kidney Disease
NCI, National Cancer Institute
OAR, Office of AIDS Research
GEI, Gene Environment Interaction Project
Other. Please specify:

For additional help with this form, or to learn more, send email to mgi-help@informatics.jax.org.

Thank you for participating!