NIH KOMP Gene Nomination: description of alleles produced by CSD
KOMP-DCC   KOMP-NIH

CSD: CHORI (Children's Hospital Oakland Research Institute), the Wellcome Trust Sanger Institute, and the University of California at Davis are using two constructs, both of which rely on identifying a key exon relevant to all transcripts of the gene. Each of these constructs can produce reporter knockouts, conditional knockouts, and null alleles. Thus, this construct is extremely flexible in the types of alleles that can be produced. However, the genes must be of sufficient size to contain a "differential" exon of note, and the approach might not be readily amenable for small genes with few exons.