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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mecp2
methyl CpG binding protein 2
MGI:99918
65 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Bdnftm3Jae/Bdnf+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J
premature death J:106973
Bdnftm3Jae/Bdnftm3Jae
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J
abnormal action potential J:106973
lethargy J:106973
premature death J:106973
Col1a1tm8(CAG-BDNF)Jae/Col1a1+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J
abnormal action potential J:106973
normal behavior/neurological phenotype J:106973
decreased brain weight J:106973
premature death J:106973
Crhtm1Maj/Crh+
Tg(MECP2)1Hzo/0
involves: 129S2/SvPas * 129S6/SvEv * C57BL/6 * FVB/N
abnormal anxiety-related response J:181213
abnormal corticosterone level J:181213
Crhr1tm1Klee/Crhr1+
Tg(MECP2)1Hzo/0
involves: 129S4/SvJae * 129S6/SvEv * C57BL/6 * FVB/N
abnormal anxiety-related response J:181213
Mapttm1(Mecp2)Jae/Mapt+
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:89593
Mapttm1(Mecp2)Jae/Mapt+
Mecp2tm1.1Jae/Mecp2+
involves: 129S4/SvJae * C57BL/6
normal behavior/neurological phenotype J:89593
normal growth/size/body region phenotype J:89593
normal nervous system phenotype J:89593
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
B6.Cg-Mapttm1(Mecp2)Jae
abnormal associative learning J:182685
abnormal contextual conditioning behavior J:182685
abnormal cued conditioning behavior J:182685
abnormal miniature excitatory postsynaptic currents J:182685
abnormal object recognition memory J:182685
decreased body weight J:182685
enhanced paired-pulse facilitation J:182685
impaired coordination J:182685
increased anxiety-related response J:182685
reduced long term potentiation J:182685
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
involves: 129/Sv * C57BL/6
abnormal sexual interaction J:89593
ataxia J:89593
cachexia J:89593
cataract J:89593
disheveled coat J:89593
excessive scratching J:89593
impaired balance J:89593
normal mortality/aging J:89593
postnatal growth retardation J:89593
tremors J:89593
Mapttm1(Setdb1)Akba/Mapt+
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
impaired coordination J:178512
premature death J:178512
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
impaired coordination J:178512
premature death J:178512
Mbd2tm1Bh/Mbd2tm1Bh
Mecp2tm1.1Bird/Y
involves: 129P2/OlaHsd * C57BL/6
abnormal motor capabilities/coordination/movement J:67910
premature death J:67910
Mecp2em1Dkatz/Mecp2+
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J
abnormal locomotor behavior J:101977
normal reproductive system phenotype J:101977
Mecp2em1Dkatz/Mecp2em1Dkatz
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J
female infertility J:101977
Mecp2em1Dkatz/Y
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J
premature death J:101977
Mecp2tm1.1Bird/Y
SqleSum3-Jus/Sqle+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
abnormal body weight J:198551
abnormal locomotor activation J:198551
decreased startle reflex J:198551
dermatitis J:198551
extended life span J:198551
impaired coordination J:198551
increased pulmonary respiratory rate J:198551
lethargy J:198551
limb grasping J:198551
malocclusion J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum1M1Jus/Sum1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
extended life span J:198551
normal growth/size/body region phenotype J:198551
lethargy J:198551
limb grasping J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum2M1Jus/Sum2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
abnormal body weight J:198551
dermatitis J:198551
extended life span J:198551
eye inflammation J:198551
lethargy J:198551
limb grasping J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum4M1Jus/Sum4+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
dermatitis J:198551
extended life span J:198551
eye inflammation J:198551
normal growth/size/body region phenotype J:198551
lethargy J:198551
limb grasping J:198551
malocclusion J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum5M1Jus/Sum5+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
abnormal body weight J:198551
extended life span J:198551
eye inflammation J:198551
lethargy J:198551
limb grasping J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Tg(MECP2)1Hzo/0
involves: 129P2/OlaHsd * FVB
normal behavior/neurological phenotype J:94407
normal mortality/aging J:94407
normal nervous system phenotype J:126964
Mecp2tm1.1Bird/Y
Tg(MECP2*G273X/GFP)#Hzo/0
involves: 129P2/OlaHsd * FVB
abnormal brain development J:194039
abnormal cerebral cortex morphology J:194039
abnormal gait J:194039
abnormal hippocampus morphology J:194039
decreased brain weight J:194039
increased body weight J:194039
premature death J:194039
tremors J:194039
Mecp2tm1.1Bird/Y
Tg(MECP2*R270X/GFP)#Hzo/0
involves: 129P2/OlaHsd * FVB
abnormal brain development J:194039
abnormal cerebral cortex morphology J:194039
abnormal gait J:194039
abnormal hippocampus morphology J:194039
decreased brain weight J:194039
disheveled coat J:194039
increased body weight J:194039
premature death J:194039
tremors J:194039
Mecp2tm1Jae/Y
Tg(Camk2a-Setdb1)1Akba/0
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
decreased body weight J:178512
hypoactivity J:178512
impaired coordination J:178512
premature death J:178512
Oprm1tm1Kff/Oprm1+
Tg(MECP2)1Hzo/0
involves: 129S2/SvPas * C57BL/6 * FVB/N
increased anxiety-related response J:181213
Tg(MECP2)1Hzo/0
either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
abnormal corticosterone level J:181213
abnormal social investigation J:181213
increased anxiety-related response J:181213
Tg(MECP2)1Hzo/0
FVB-Tg(MECP2)1Hzo/J
abnormal visual acuity J:253720
abnormal visual contrast sensitivity J:253720
abnormal visual evoked potential J:253720
Tg(MECP2)1Hzo/0
involves: FVB
abnormal contextual conditioning behavior J:94407
abnormal excitatory postsynaptic currents J:126964
abnormal miniature excitatory postsynaptic currents J:126964
abnormal motor coordination/balance J:94407
abnormal synaptic vesicle number J:126964
clonic seizures J:94407
decreased anxiety-related response J:94407
enhanced coordination J:94407
enhanced long term potentiation J:94407
enhanced paired-pulse facilitation J:94407
hypoactivity J:94407
increased aggression J:94407
increased CNS synapse formation J:126964
increased vertical activity J:94407
kyphosis J:94407
limb grasping J:94407
normal nervous system phenotype J:126964
premature death J:94407
Tg(MECP2)3Hzo/0
either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
abnormal social investigation J:181213
hypoactivity J:181213
increased anxiety-related response J:181213
Tg(MECP2)3Hzo/0
involves: FVB
hypoactivity J:94407
increased aggression J:94407
kyphosis J:94407
limb grasping J:94407
postnatal lethality J:94407
Tg(MECP2*G273X/GFP)#Hzo/0
involves: 129P2/OlaHsd * FVB
no abnormal phenotype detected J:194039
Tg(MECP2*R270X/GFP)#Hzo/0
involves: 129P2/OlaHsd * FVB
no abnormal phenotype detected J:194039

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory