Ryr2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ryr2
ryanodine receptor 2, cardiac
MGI:99685

86 phenotypes from 28 alleles in 24 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ryr2^em1Swch/Ryr2⁺ involves: 129 * C57BL/6	abnormal action potential	J:302151
	abnormal heart echocardiography feature	J:302151
	abnormal myocardial fiber calcium currents	J:302151
	abnormal myocardial fiber physiology	J:302151
	abnormal myocardial fiber sodium currents	J:302151
	decreased heart rate	J:302151
	decreased response of heart to induced stress	J:302151
	irregular heartbeat	J:302151
Ryr2^em1Swch/Ryr2^em1Swch involves: 129 * C57BL/6	prenatal lethality, complete penetrance	J:302151
Ryr2^M1Btlr/Ryr2^M1Btlr C57BL/6J-Ryr2^M1Btlr	increased heart rate	J:267528
Ryr2^m2Btlr/Ryr2^m2Btlr C57BL/6J-Ryr2^m2Btlr	decreased heart rate	J:267529
Ryr2^m3Btlr/Ryr2^m3Btlr C57BL/6J-Ryr2^m3Btlr	decreased heart rate	J:267530
Ryr2^tm1.1Clhh/Ryr2⁺ 129S/SvEv-Ryr2^tm1.1Clhh	abnormal myocardial fiber physiology	J:186379
	irregular heartbeat	J:186379
	ventricular tachycardia	J:186379
Ryr2^tm1.1Clhh/Ryr2^tm1.1Clhh 129S/SvEv-Ryr2^tm1.1Clhh	abnormal myocardial fiber physiology	J:186379
	irregular heartbeat	J:186379
	ventricular tachycardia	J:186379
Ryr2^tm1.1Hnis/Ryr2^tm1.1Hnis involves: C57BL/6	abnormal mesenteric lymph node morphology	J:228787
	abnormal spleen white pulp morphology	J:228787
	normal cardiovascular system phenotype	J:228787
	enlarged mesenteric lymph nodes	J:228787
	normal growth/size/body region phenotype	J:228787
	normal immune system phenotype	J:228787
	increased spleen weight	J:228787
	increased thymus weight	J:228787
	large lymphoid organs	J:228787
	normal nervous system phenotype	J:228787
	normal renal/urinary system phenotype	J:228787
	thymus cortex hyperplasia	J:228787
Ryr2^tm1.1Hta/Ryr2^tm1.1Hta involves: 129S4/SvJae	abnormal epicardium morphology	J:48277
	abnormal fetal cardiomyocyte mitochondrial morphology	J:48277
	abnormal fetal cardiomyocyte morphology	J:48277
	abnormal fetal cardiomyocyte physiology	J:48277
	abnormal myocardial trabeculae morphology	J:48277
	disorganized myocardium	J:48277
	embryonic growth retardation	J:48277
	embryonic lethality during organogenesis, complete penetrance	J:48277
	fetal cardiomyocyte vacuoles	J:48277
Ryr2^tm1.1Maya/Ryr2⁺ C57BL/6J-Ryr2^tm1.1Maya	abnormal myocardial fiber physiology	J:159451
	normal behavior/neurological phenotype	J:159451
	increased physiological sensitivity to xenobiotic	J:159451
	ventricular tachycardia	J:159451
Ryr2^tm1.1Msnr/Ryr2⁺ involves: 129S6/SvEvTac * FVB/N	abnormal heart morphology	J:122033
Ryr2^tm1.1Msnr/Ryr2⁺ involves: 129S6/SvEvTac * FVB/N	enlarged heart	J:122033
Ryr2^tm1.1Msnr/Ryr2^tm1.1Msnr involves: 129S6/SvEvTac * FVB/N	cardiac fibrosis	J:122033
	decreased body weight	J:122033
	decreased heart rate	J:122033
	decreased ventricle muscle contractility	J:122033
	enlarged heart	J:122033
	heart left ventricle hypertrophy	J:122033
	postnatal lethality, complete penetrance	J:122033
	thin interventricular septum	J:122033
Ryr2^tm1.1Swch/Ryr2⁺ involves: 129S1/Sv * 129X1/SvJ * Black Swiss	increased physiological sensitivity to xenobiotic	J:174541
	ventricular tachycardia	J:174541
Ryr2^tm1.1Swch/Ryr2^tm2.1Swch involves: 129S1/Sv * 129X1/SvJ * Black Swiss	abnormal cardiovascular system physiology	J:214434
Ryr2^tm1.1Wex/Ryr2^tm1.1Wex B6.129S7-Ryr2^tm1.1Wex	normal cardiovascular system phenotype	J:179475
	increased response of heart to induced stress	J:179475
	ventricular tachycardia	J:179475
Ryr2^tm1.1Wex/Ryr2^tm1.1Wex involves: 129S7/SvEvBrd	abnormal response of heart to induced stress	J:152544
Ryr2^tm1Amks/Ryr2^tm1Amks involves: 129S/SvEv * C57BL/6	abnormal response to cardiac infarction	J:105666
Ryr2^{tm1b(KOMP)Wtsi}/Ryr2⁺ C57BL/6N-Ryr2^{tm1b(KOMP)Wtsi}/H	increased startle reflex	J:211773
Ryr2^{tm1b(KOMP)Wtsi}/Ryr2^{tm1b(KOMP)Wtsi} C57BL/6N-Ryr2^{tm1b(KOMP)Wtsi}/H	preweaning lethality, complete penetrance	J:211773
Ryr2^tm1Hhv/Ryr2^tm1Hhv involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal myocardial fiber morphology	J:141342
	normal cardiovascular system phenotype	J:141342
Ryr2^tm1Hta/Ryr2^tm1Hta involves: 129S4/SvJae	no abnormal phenotype detected	J:48277
Ryr2^tm1Krbr/Ryr2^tm1Krbr A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S1/Sv 129X1/SvJ * C57BL/6 * FVB/N	abnormal atrial thrombosis	J:210083
	abnormal sinus arrhythmia	J:210083
	abnormal T wave	J:210083
	atrioventricular block	J:210083
	cardiomyopathy	J:210083
	congestive heart failure	J:210083
	decreased cardiac output	J:210083
	decreased heart rate	J:210083
	increased heart rate	J:210083
	lethargy	J:210083
	premature death	J:210083
	sinus bradycardia	J:210083
Ryr2^tm1Krbr/Ryr2^tm3.1Swch A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S1/Sv 129X1/SvJ * FVB/N	decreased heart rate	J:215190
	premature death	J:215190
Ryr2^tm1Sgp/Ryr2⁺ involves: 129/Sv * C57BL/6	normal cardiovascular system phenotype	J:109683
	irregular heartbeat	J:109683
	ventricular fibrillation	J:109683
	ventricular tachycardia	J:109683
Ryr2^tm1Slh/Ryr2⁺ involves: 129S7/SvEvBrd	abnormal myocardial fiber physiology	J:152544
	abnormal response of heart to induced stress	J:152544
	irregular heartbeat	J:152544
Ryr2^tm1Slh/Ryr2⁺ involves: 129S7/SvEvBrd * C57BL/6	abnormal myocardial fiber physiology	J:111780
	cardiomyopathy	J:111780
	decreased cardiac muscle contractility	J:111780
	ventricular premature beat	J:111780
	ventricular tachycardia	J:111780
Ryr2^tm1Slh/Ryr2⁺ involves: 129S7/SvEvBrd * C57BL/6J	abnormal afterhyperpolarization	J:235432
	abnormal brain wave pattern	J:235432
	abnormal heart electrocardiography waveform feature	J:235432
	abnormal miniature excitatory postsynaptic currents	J:235432
	abnormal nervous system electrophysiology	J:235432
	atrioventricular block	J:235432
	decreased heart rate	J:235432
	decreased paired-pulse ratio	J:235432
	increased susceptibility to induced morbidity/mortality	J:235432
	increased susceptibility to pharmacologically induced seizures	J:235432
	irregular heartbeat	J:235432
	ventricular fibrillation	J:235432
Ryr2^tm2.1Maya/Ryr2⁺ involves: C57BL/6J	abnormal myocardial fiber physiology	J:186291
	normal cardiovascular system phenotype	J:186291
	ventricular tachycardia	J:186291
Ryr2^tm2.1Msnr/Ryr2^tm2.1Msnr 129S.129P2-Ryr2^tm2.1Msnr	abnormal heart left ventricle morphology	J:200958
	abnormal heart right ventricle morphology	J:200958
	cardiac hypertrophy	J:200958
	normal cardiovascular system phenotype	J:200958
	increased heart weight	J:200958
	thick interventricular septum	J:200958
	thick ventricular wall	J:200958
Ryr2^tm2.1Swch/Ryr2⁺ involves: 129S1/Sv * 129X1/SvJ * Black Swiss	abnormal cardiac muscle contractility	J:214434
	abnormal cardiovascular system physiology	J:214434
	abnormal myocardial fiber physiology	J:214434
Ryr2^tm2.1Swch/Ryr2^tm2.1Swch involves: 129S1/Sv * 129X1/SvJ * Black Swiss	embryonic lethality during organogenesis, complete penetrance	J:214434
Ryr2^tm2.1Wex/Ryr2^tm2.1Wex B6.129S7-Ryr2^tm2.1Wex	abnormal heart left ventricle morphology	J:179475
	abnormal myocardial fiber morphology	J:179475
	absent heartbeat	J:179475
	normal cardiovascular system phenotype	J:179475
	decreased cardiac muscle contractility	J:179475
	decreased heart rate	J:179475
	increased response of heart to induced stress	J:179475
	increased susceptibility to induced morbidity/mortality	J:179475
	ventricular premature beat	J:179475
	ventricular tachycardia	J:179475
Ryr2^tm2.1Wex/Ryr2^tm2.1Wex involves: 129S7/SvEvBrd	abnormal sarcoplasmic reticulum morphology	J:210426
Ryr2^tm2Amks/Ryr2⁺ B6.129-Ryr2^tm2Amks	abnormal brain wave pattern	J:137696
	abnormal myocardial fiber physiology	J:137696
	increased response of heart to induced stress	J:137696
	increased susceptibility to induced morbidity/mortality	J:137696
	increased susceptibility to pharmacologically induced seizures	J:137696
	normal nervous system phenotype	J:137696
	tonic-clonic seizures	J:137696
	ventricular tachycardia	J:137696
Ryr2^tm2Amks/Ryr2⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal myocardial fiber morphology	J:212640
	abnormal sarcoplasmic reticulum morphology	J:212640
	atrial fibrillation	J:212640
Ryr2^tm2Amks/Ryr2^tm2Amks B6.129-Ryr2^tm2Amks	decreased survivor rate	J:137696
	fetal growth retardation	J:137696
	increased susceptibility to pharmacologically induced seizures	J:137696
	lethality throughout fetal growth and development, incomplete penetrance	J:137696
	tonic-clonic seizures	J:137696
Ryr2^tm2Hhv/Ryr2⁺ involves: 129 * C57BL/6	abnormal cardiovascular system physiology	J:212870
	abnormal myocardial fiber physiology	J:212870
	irregular heartbeat	J:212870
	ventricular premature beat	J:212870
Ryr2^tm2Hhv/Ryr2^tm2Hhv involves: 129 * C57BL/6	embryonic lethality, complete penetrance	J:212870
Ryr2^tm3.1Amks/Ryr2⁺ involves: C57BL/6	abnormal myocardial fiber morphology	J:212640
	abnormal sarcoplasmic reticulum morphology	J:212640
	atrial fibrillation	J:212640
Ryr2^tm3.1Hhv/Ryr2⁺ involves: 129S7/SvEvBrd * C57BL/6	abnormal myocardial fiber physiology	J:220671
	decreased heart rate	J:220671
	ventricular fibrillation	J:220671
Ryr2^tm3.1Hhv/Ryr2^tm3.1Hhv involves: 129S7/SvEvBrd * C57BL/6	prenatal lethality, complete penetrance	J:220671
Ryr2^tm3.1Swch/Ryr2⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal myocardial fiber physiology	J:215190
Ryr2^tm3.1Swch/Ryr2^tm3.1Swch involves: 129S1/Sv * 129X1/SvJ	embryonic lethality, complete penetrance	J:215190
Ryr2^tm4.1Amks/Ryr2⁺ involves: 129 * C57BL/6	abnormal myocardial fiber morphology	J:212640
	abnormal sarcoplasmic reticulum morphology	J:212640
	atrial fibrillation	J:212640

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