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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ryr2
ryanodine receptor 2, cardiac
MGI:99685
78 phenotypes from 27 alleles in 24 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Ryr2M1Btlr/Ryr2M1Btlr
C57BL/6J-Ryr2M1Btlr
increased heart rate J:267528
Ryr2m2Btlr/Ryr2m2Btlr
C57BL/6J-Ryr2m2Btlr
decreased heart rate J:267529
Ryr2m3Btlr/Ryr2m3Btlr
C57BL/6J-Ryr2m3Btlr
decreased heart rate J:267530
Ryr2tm1.1Clhh/Ryr2+
129S/SvEv-Ryr2tm1.1Clhh
abnormal myocardial fiber physiology J:186379
irregular heartbeat J:186379
ventricular tachycardia J:186379
Ryr2tm1.1Clhh/Ryr2tm1.1Clhh
129S/SvEv-Ryr2tm1.1Clhh
abnormal myocardial fiber physiology J:186379
irregular heartbeat J:186379
ventricular tachycardia J:186379
Ryr2tm1.1Hnis/Ryr2tm1.1Hnis
involves: C57BL/6
abnormal mesenteric lymph node morphology J:228787
abnormal spleen white pulp morphology J:228787
normal cardiovascular system phenotype J:228787
enlarged mesenteric lymph nodes J:228787
normal growth/size/body region phenotype J:228787
normal immune system phenotype J:228787
increased spleen weight J:228787
increased thymus weight J:228787
large lymphoid organs J:228787
normal nervous system phenotype J:228787
normal renal/urinary system phenotype J:228787
thymus cortex hyperplasia J:228787
Ryr2tm1.1Hta/Ryr2tm1.1Hta
involves: 129S4/SvJae
abnormal epicardium morphology J:48277
abnormal fetal cardiomyocyte morphology J:48277
abnormal myocardial fiber physiology J:48277
abnormal myocardial trabeculae morphology J:48277
disorganized myocardium J:48277
embryonic growth retardation J:48277
embryonic lethality during organogenesis, complete penetrance J:48277
Ryr2tm1.1Maya/Ryr2+
C57BL/6J-Ryr2tm1.1Maya
abnormal myocardial fiber physiology J:159451
normal behavior/neurological phenotype J:159451
increased physiological sensitivity to xenobiotic J:159451
ventricular tachycardia J:159451
Ryr2tm1.1Msnr/Ryr2+
involves: 129S6/SvEvTac * FVB/N
abnormal heart morphology J:122033
enlarged heart J:122033
Ryr2tm1.1Msnr/Ryr2tm1.1Msnr
involves: 129S6/SvEvTac * FVB/N
cardiac fibrosis J:122033
decreased body weight J:122033
decreased heart rate J:122033
decreased ventricle muscle contractility J:122033
enlarged heart J:122033
heart left ventricle hypertrophy J:122033
postnatal lethality, complete penetrance J:122033
thin interventricular septum J:122033
Ryr2tm1.1Swch/Ryr2+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
increased physiological sensitivity to xenobiotic J:174541
ventricular tachycardia J:174541
Ryr2tm1.1Swch/Ryr2tm2.1Swch
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
abnormal cardiovascular system physiology J:214434
Ryr2tm1.1Wex/Ryr2tm1.1Wex
B6.129S7-Ryr2tm1.1Wex
normal cardiovascular system phenotype J:179475
increased response of heart to induced stress J:179475
ventricular tachycardia J:179475
Ryr2tm1.1Wex/Ryr2tm1.1Wex
involves: 129S7/SvEvBrd
altered response of heart to induced stress J:152544
Ryr2tm1Amks/Ryr2tm1Amks
involves: 129S/SvEv * C57BL/6
altered response to myocardial infarction J:105666
Ryr2tm1b(KOMP)Wtsi/Ryr2+
C57BL/6N-Ryr2tm1b(KOMP)Wtsi/H
increased startle reflex J:211773
Ryr2tm1b(KOMP)Wtsi/Ryr2tm1b(KOMP)Wtsi
C57BL/6N-Ryr2tm1b(KOMP)Wtsi/H
preweaning lethality, complete penetrance J:211773
Ryr2tm1Hhv/Ryr2tm1Hhv
involves: 129S1/Sv * 129X1/SvJ * FVB/N
abnormal myocardial fiber morphology J:141342
normal cardiovascular system phenotype J:141342
Ryr2tm1Hta/Ryr2tm1Hta
involves: 129S4/SvJae
no abnormal phenotype detected J:48277
Ryr2tm1Krbr/Ryr2tm1Krbr
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
abnormal atrial thrombosis J:210083
abnormal sinus arrhythmia J:210083
abnormal T wave J:210083
atrioventricular block J:210083
cardiomyopathy J:210083
congestive heart failure J:210083
decreased cardiac output J:210083
decreased heart rate J:210083
increased heart rate J:210083
lethargy J:210083
premature death J:210083
sinus bradycardia J:210083
Ryr2tm1Krbr/Ryr2tm3.1Swch
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
decreased heart rate J:215190
premature death J:215190
Ryr2tm1Sgp/Ryr2+
involves: 129/Sv * C57BL/6
normal cardiovascular system phenotype J:109683
irregular heartbeat J:109683
ventricular fibrillation J:109683
ventricular tachycardia J:109683
Ryr2tm1Slh/Ryr2+
involves: 129S7/SvEvBrd
abnormal myocardial fiber physiology J:152544
altered response of heart to induced stress J:152544
irregular heartbeat J:152544
Ryr2tm1Slh/Ryr2+
involves: 129S7/SvEvBrd * C57BL/6
abnormal myocardial fiber physiology J:111780
cardiomyopathy J:111780
decreased cardiac muscle contractility J:111780
ventricular premature beat J:111780
ventricular tachycardia J:111780
Ryr2tm1Slh/Ryr2+
involves: 129S7/SvEvBrd * C57BL/6J
abnormal afterhyperpolarization J:235432
abnormal brain wave pattern J:235432
abnormal heart electrocardiography waveform feature J:235432
abnormal miniature excitatory postsynaptic currents J:235432
abnormal nervous system electrophysiology J:235432
abnormal synaptic transmission J:235432
atrioventricular block J:235432
decreased heart rate J:235432
increased sensitivity to induced morbidity/mortality J:235432
increased susceptibility to pharmacologically induced seizures J:235432
irregular heartbeat J:235432
ventricular fibrillation J:235432
Ryr2tm2.1Maya/Ryr2+
involves: C57BL/6J
abnormal myocardial fiber physiology J:186291
normal cardiovascular system phenotype J:186291
ventricular tachycardia J:186291
Ryr2tm2.1Msnr/Ryr2tm2.1Msnr
129S.129P2-Ryr2tm2.1Msnr
abnormal heart left ventricle morphology J:200958
abnormal heart right ventricle morphology J:200958
cardiac hypertrophy J:200958
normal cardiovascular system phenotype J:200958
increased heart weight J:200958
thick interventricular septum J:200958
thick ventricular wall J:200958
Ryr2tm2.1Swch/Ryr2+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
abnormal cardiac muscle contractility J:214434
abnormal cardiovascular system physiology J:214434
abnormal myocardial fiber physiology J:214434
Ryr2tm2.1Swch/Ryr2tm2.1Swch
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
embryonic lethality during organogenesis, complete penetrance J:214434
Ryr2tm2.1Wex/Ryr2tm2.1Wex
B6.129S7-Ryr2tm2.1Wex
abnormal heart left ventricle morphology J:179475
abnormal myocardial fiber morphology J:179475
absent heartbeat J:179475
normal cardiovascular system phenotype J:179475
decreased cardiac muscle contractility J:179475
decreased heart rate J:179475
increased response of heart to induced stress J:179475
increased sensitivity to induced morbidity/mortality J:179475
ventricular premature beat J:179475
ventricular tachycardia J:179475
Ryr2tm2.1Wex/Ryr2tm2.1Wex
involves: 129S7/SvEvBrd
abnormal sarcoplasmic reticulum morphology J:210426
Ryr2tm2Amks/Ryr2+
B6.129-Ryr2tm2Amks
abnormal brain wave pattern J:137696
abnormal myocardial fiber physiology J:137696
increased response of heart to induced stress J:137696
increased sensitivity to induced morbidity/mortality J:137696
increased susceptibility to pharmacologically induced seizures J:137696
normal nervous system phenotype J:137696
tonic-clonic seizures J:137696
ventricular tachycardia J:137696
Ryr2tm2Amks/Ryr2+
involves: 129S1/Sv * 129X1/SvJ
abnormal myocardial fiber morphology J:212640
abnormal sarcoplasmic reticulum morphology J:212640
atrial fibrillation J:212640
Ryr2tm2Amks/Ryr2tm2Amks
B6.129-Ryr2tm2Amks
decreased survivor rate J:137696
fetal growth retardation J:137696
increased susceptibility to pharmacologically induced seizures J:137696
lethality throughout fetal growth and development, incomplete penetrance J:137696
tonic-clonic seizures J:137696
Ryr2tm2Hhv/Ryr2+
involves: 129 * C57BL/6
abnormal cardiovascular system physiology J:212870
abnormal myocardial fiber physiology J:212870
irregular heartbeat J:212870
ventricular premature beat J:212870
Ryr2tm2Hhv/Ryr2tm2Hhv
involves: 129 * C57BL/6
embryonic lethality, complete penetrance J:212870
Ryr2tm3.1Amks/Ryr2+
involves: C57BL/6
abnormal myocardial fiber morphology J:212640
abnormal sarcoplasmic reticulum morphology J:212640
atrial fibrillation J:212640
Ryr2tm3.1Hhv/Ryr2+
involves: 129S7/SvEvBrd * C57BL/6
abnormal myocardial fiber physiology J:220671
decreased heart rate J:220671
ventricular fibrillation J:220671
Ryr2tm3.1Hhv/Ryr2tm3.1Hhv
involves: 129S7/SvEvBrd * C57BL/6
prenatal lethality, complete penetrance J:220671
Ryr2tm3.1Swch/Ryr2+
involves: 129S1/Sv * 129X1/SvJ
abnormal myocardial fiber physiology J:215190
Ryr2tm3.1Swch/Ryr2tm3.1Swch
involves: 129S1/Sv * 129X1/SvJ
embryonic lethality, complete penetrance J:215190
Ryr2tm4.1Amks/Ryr2+
involves: 129 * C57BL/6
abnormal myocardial fiber morphology J:212640
abnormal sarcoplasmic reticulum morphology J:212640
atrial fibrillation J:212640

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory