Siglec1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Siglec1
sialic acid binding Ig-like lectin 1, sialoadhesin
MGI:99668

17 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Siglec1^{tm1.1(KOMP)Vlcg}/Siglec1^{tm1.1(KOMP)Vlcg} C57BL/6N-Siglec1^{tm1.1(KOMP)Vlcg}/Ucd	increased kidney weight	J:211773
	increased lung weight	J:211773
Siglec1^tm1Croc/Siglec1^tm1Croc B6.129-Siglec1^tm1Croc	abnormal B cell number	J:105546
	abnormal T cell subpopulation ratio	J:105546
	decreased circulating interleukin-6 level	J:189854
	decreased circulating tumor necrosis factor level	J:189854
	decreased follicular B cell number	J:105546
	decreased IgM level	J:105546
	decreased interleukin-6 secretion	J:189854
	decreased interleukin-10 secretion	J:189854
	decreased interleukin-12 secretion	J:189854
	decreased tumor necrosis factor secretion	J:189854
	impaired macrophage phagocytosis	J:189854
	increased CD8-positive, alpha-beta T cell number	J:105546
	increased marginal zone B cell number	J:105546
	increased susceptibility to bacterial infection	J:189854
Siglec1^tm2.1Croc/Siglec1^tm2.1Croc B6.129P2(C)-Siglec1^tm2.1Croc	decreased circulating interleukin-6 level	J:189854
	decreased circulating tumor necrosis factor level	J:189854
	decreased susceptibility to bacterial infection	J:189854
	impaired macrophage phagocytosis	J:189854

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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