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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Siglec1
sialic acid binding Ig-like lectin 1, sialoadhesin
MGI:99668
15 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Siglec1tm1Croc/Siglec1tm1Croc
B6.129-Siglec1tm1Croc
abnormal B cell number J:105546
abnormal T cell subpopulation ratio J:105546
decreased circulating interleukin-6 level J:189854
decreased circulating tumor necrosis factor level J:189854
decreased follicular B cell number J:105546
decreased IgM level J:105546
decreased interleukin-6 secretion J:189854
decreased interleukin-10 secretion J:189854
decreased interleukin-12 secretion J:189854
decreased tumor necrosis factor secretion J:189854
impaired macrophage phagocytosis J:189854
increased CD8-positive, alpha-beta T cell number J:105546
increased marginal zone B cell number J:105546
increased susceptibility to bacterial infection J:189854
Siglec1tm2.1Croc/Siglec1tm2.1Croc
B6.129P2(C)-Siglec1tm2.1Croc
decreased circulating interleukin-6 level J:189854
decreased circulating tumor necrosis factor level J:189854
decreased susceptibility to bacterial infection J:189854
impaired macrophage phagocytosis J:189854

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory