93 phenotypes from 14 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ryr1em1Tmur/Ryr1+ Not Specified	abnormal body temperature homeostasis	J:322211
	abnormal muscle physiology	J:322211
	increased physiological sensitivity to xenobiotic	J:322211
	increased susceptibility to malignant hyperthermia	J:322211
Ryr1em1Tmur/Ryr1em1Tmur Not Specified	lethality throughout fetal growth and development, complete penetrance	J:322211
Ryr1m1Bei/Ryr1m1Bei involves: A/J * FVB/N	abnormal skeletal muscle morphology	J:75360
	decreased body length	J:75360
	increased body weight	J:75360
	thin ribs	J:75360
Ryr1m1Nisw/Ryr1+ 129S1.B6-Ryr1m1Nisw	abnormal mitochondrial physiology	J:219285
	abnormal mitochondrial shape	J:219285
	abnormal potassium ion homeostasis	J:219285
	abnormal sarcomere morphology	J:219285
	abnormal sarcoplasmic reticulum morphology	J:219285
	abnormal skeletal muscle fiber morphology	J:219285
	abnormal Z line morphology	J:219285
	centrally nucleated skeletal muscle fibers	J:219285
	decreased grip strength	J:219285
	increased circulating potassium level	J:219285
	muscle weakness	J:219285
	myopathy	J:219285
Ryr1tm1.1Dhm/Ryr1+ involves: 129S2/SvPasCrl * 129S6/SvEvTac	abnormal locomotor behavior	J:155825
	abnormal muscle fiber morphology	J:155825
	abnormal sarcomere morphology	J:155825
	abnormal skeletal muscle fiber morphology	J:155825
	abnormal Z line morphology	J:155825
	cyanosis	J:155825
	decreased body weight	J:155825
	decreased skeletal muscle fiber diameter	J:155825
	decreased total body fat amount	J:155825
	hindlimb paralysis	J:155825
	impaired muscle contractility	J:155825
	increased variability of skeletal muscle fiber size	J:155825
	kyphosis	J:155825
	muscle weakness	J:155825
	myopathy	J:155825
	respiratory distress	J:155825
Ryr1tm1.1Dhm/Ryr1tm1.1Dhm involves: 129S6/SvEvTac * 129X1/SvJ	abnormal coronary artery morphology	J:127629
	abnormal dermal layer morphology	J:127629
	abnormal diaphragm morphology	J:127629
	abnormal interventricular groove morphology	J:127629
	abnormal muscle development	J:127629
	abnormal muscle physiology	J:127629
	abnormal posture	J:127629
	abnormal skin condition	J:127629
	abnormal thoracic cage shape	J:127629
	cleft secondary palate	J:127629
	cyanosis	J:127629
	decreased birth body size	J:127629
	decreased birth weight	J:127629
	decreased skeletal muscle mass	J:127629
	delayed bone ossification	J:127629
	delayed heart development	J:127629
	domed cranium	J:127629
	fetal growth retardation	J:127629
	impaired skeletal muscle contractility	J:127629
	increased brown adipose tissue amount	J:127629
	kyphosis	J:127629
	neonatal lethality, complete penetrance	J:127629
	ostium primum atrial septal defect	J:127629
	ostium secundum atrial septal defect	J:127629
	paralysis	J:127629
	skeletal muscle degeneration	J:127629
	skin edema	J:127629
	tight skin	J:127629
	translucent skin	J:127629
	underdeveloped hair follicles	J:127629
	unresponsive to tactile stimuli	J:127629
Ryr1tm1.1Inp/Ryr1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal muscle physiology	J:181523
	abnormal physiological response to xenobiotic	J:181523
	increased core body temperature	J:181523
	increased susceptibility to malignant hyperthermia	J:181523
Ryr1tm1.1Inp/Ryr1tm1.1Inp involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal muscle physiology	J:181523
	abnormal physiological response to xenobiotic	J:181523
	abnormal soleus morphology	J:181523
	acidemia	J:181523
	impaired muscle relaxation	J:181523
	increased core body temperature	J:181523
	increased susceptibility to malignant hyperthermia	J:181523
Ryr1tm1.1Itl/? B6.Cg-Ryr1tm1.1Itl	abnormal muscle contractility	J:176731
	abnormal muscle physiology	J:176731
	abnormal skeletal muscle morphology	J:176731
Ryr1tm1.1Msnr/Ryr1tm1.1Msnr 129S.129P2-Ryr1tm1.1Msnr	abnormal muscle contractility	J:195542
	abnormal muscle electrophysiology	J:195542
	muscle tetany	J:195542
	muscle twitch	J:195542
Ryr1tm1Alle/Ryr1tm1Alle involves: 129S4/SvJae * C57BL/6	abnormal cell physiology	J:111187
Ryr1tm1b(EUCOMM)Hmgu/Ryr1+ C57BL/6N-Ryr1tm1b(EUCOMM)Hmgu/H	increased respiratory quotient	J:211773
	increased spleen weight	J:211773
Ryr1tm1b(EUCOMM)Hmgu/Ryr1tm1b(EUCOMM)Hmgu C57BL/6N-Ryr1tm1b(EUCOMM)Hmgu/H	preweaning lethality, complete penetrance	J:211773
Ryr1tm1Slh/Ryr1+ involves: 129S7/SvEvBrd * C57BL/6	abnormal body temperature homeostasis	J:105738
	abnormal muscle contractility	J:105738
	abnormal muscle physiology	J:105738
	enhanced behavioral response to xenobiotic	J:105738
	increased circulating potassium level	J:105738
Ryr1tm1Slh/Ryr1tm1Slh involves: 129S7/SvEvBrd * C57BL/6	abnormal muscle physiology	J:105738
	abnormal rib morphology	J:105738
	abnormal skeletal muscle fiber morphology	J:105738
	abnormal skeletal muscle morphology	J:105738
	abnormal thoracic cage shape	J:105738
	edema	J:105738
	increased variability of skeletal muscle fiber size	J:105738
	kyphosis	J:105738
	omphalocele	J:105738
	pectus excavatum	J:105738
	perinatal lethality, complete penetrance	J:105738
Ryr1tm1Tno/Ryr1tm1Tno involves: 129S4/SvJae * C57BL/6J	abnormal axial skeleton morphology	J:18895
	abnormal limb morphology	J:18895
	abnormal skeletal muscle fiber morphology	J:18895
	abnormal spine curvature	J:18895
	centrally nucleated skeletal muscle fibers	J:18895
	cyanosis	J:18895
	decreased skeletal muscle fiber number	J:18895
	decreased skeletal muscle fiber size	J:18895
	impaired skeletal muscle contractility	J:18895
	increased variability of skeletal muscle fiber size	J:18895
	neonatal lethality, complete penetrance	J:18895
	no spontaneous movement	J:18895
	respiratory failure	J:18895
Ryr1tm2.1Alle/Ryr1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal calcium ion homeostasis	J:168222
	acidemia	J:168222
	hypercapnia	J:168222
	increased pulmonary respiratory rate	J:168222
	increased susceptibility to malignant hyperthermia	J:168222
	increased susceptibility to xenobiotic induced morbidity/mortality	J:168222
Ryr1tm2.1Alle/Ryr1tm2.1Alle involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal calcium ion homeostasis	J:168222
	lethality throughout fetal growth and development, complete penetrance	J:168222
Ryr1tm2.1Itl/? B6.Cg-Ryr1tm2.1Itl	abnormal muscle physiology	J:205099
	abnormal skeletal muscle fiber morphology	J:205099
	decreased grip strength	J:205099
	normal muscle phenotype	J:205099
Ryr1tm3.1Alle/Ryr1+ involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal body temperature homeostasis	J:303297
	abnormal muscle physiology	J:303297
	increased physiological sensitivity to xenobiotic	J:303297
	increased susceptibility to induced morbidity/mortality	J:303297
	increased susceptibility to malignant hyperthermia	J:303297
Ryr1tm3.1Alle/Ryr1tm3.1Alle involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal body temperature homeostasis	J:303297
	abnormal muscle physiology	J:303297
	increased physiological sensitivity to xenobiotic	J:303297
	increased susceptibility to induced morbidity/mortality	J:303297
	increased susceptibility to malignant hyperthermia	J:303297
	premature death	J:303297