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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abca1
ATP-binding cassette, sub-family A member 1
MGI:99607
32 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ 		abnormal bone marrow cell morphology/development J:190966
abnormal bone structure J:190966
abnormal common myeloid progenitor cell morphology J:190966
abnormal hematopoietic system physiology J:190966
decreased monocyte cell number J:190966
extramedullary hematopoiesis J:190966
increased hematopoietic stem cell number J:190966
increased monocyte cell number J:190966
increased neutrophil cell number J:190966
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ 		abnormal chemokine secretion J:130777
abnormal cytokine secretion J:130777
decreased cholesterol efflux J:130777
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Apoetm1Unc/Apoetm1Unc
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ 		abnormal hematopoietic system physiology J:190966
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Tg(APOA1)1Rub/0
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ 		abnormal hematopoietic system physiology J:190966
Abca1tm1Jdm/Abca1tm1Jdm
Tg(Thy1-APP)3Somm/0
involves: C57BL/6J * DBA/1LacJ * DBA/2 		amyloidosis J:105902
cerebral amyloid angiopathy J:105902
intracerebral hemorrhage J:105902
preweaning lethality, incomplete penetrance J:105902
Abca1tm1Jdm/Abca1tm1Jdm
Tgm2tm1Gml/Tgm2tm1Gml
involves: C57BL/6 * DBA/1LacJ 		abnormal thymus morphology J:132254
decreased circulating cholesterol level J:132254
decreased circulating HDL cholesterol level J:132254
normal homeostasis/metabolism phenotype J:132254
impaired macrophage phagocytosis J:132254
perinatal lethality J:132254
Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		abnormal bone marrow cell morphology/development J:190966
increased interleukin-17 secretion J:190966
increased interleukin-23 secretion J:190966
Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Tg(Itgax-cre,-EGFP)4097Ach/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J 		abnormal bone marrow cell morphology/development J:190966
increased interleukin-17 secretion J:190966
increased interleukin-23 secretion J:190966
Abca1tm1Wpfl/Abca1tm1Wpfl
Npc1m1N/Npc1m1N
involves: 129P2/OlaHsd * BALB/c 		decreased brain cholesterol level J:130969
increased cholesterol level J:130969
premature death J:130969
Abca1tm2Jp/Abca1+
Tg(APOA1)427Bres/?
involves: 129X1/SvJ * C57BL/6J * CBA/J 		abnormal circulating cholesterol level J:104719
abnormal circulating protein level J:104719
decreased circulating HDL cholesterol level J:104719
decreased circulating phospholipid level J:104719
Abca1tm2Jp/Abca1tm2Jp
Tg(APOA1)427Bres/?
involves: 129X1/SvJ * C57BL/6J * CBA/J 		abnormal circulating cholesterol level J:104719
abnormal circulating protein level J:104719
abnormal kidney physiology J:104719
decreased circulating HDL cholesterol level J:104719
decreased circulating phospholipid level J:104719
Apoetm1Unc/Apoetm1Unc
Tg(Prnp-Abca1)EHol/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		amyloid beta deposits J:131400
Tg(APPV717F)109Ili/0
Tg(Prnp-Abca1)EHol/0
involves: C57BL/6 * CBA 		amyloid beta deposits J:131400
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory