En1tm7(cre/ESR1)Alj/0
Fgf8tm1.1Jyhl/Fgf8tm1.3Mrt
involves: 129P2/OlaHsd * 129S6/SvEvTac
|
abnormal midbrain morphology |
J:156717
|
|
abnormal neural tube morphology |
J:156717
|
|
abnormal Raphe nucleus morphology |
J:156717
|
|
abnormal rhombomere morphology |
J:156717
|
|
abnormal serotonergic neuron morphology |
J:156717
|
|
abnormal substantia nigra morphology |
J:156717
|
|
decreased dopaminergic neuron number |
J:156717
|
|
perinatal lethality, complete penetrance |
J:156717
|
|
small cerebellum |
J:156717
|
En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd * 129S6/SvEvTac
|
abnormal midbrain morphology |
J:156717
|
|
abnormal Raphe nucleus morphology |
J:156717
|
|
abnormal serotonergic neuron morphology |
J:156717
|
|
abnormal substantia nigra morphology |
J:156717
|
|
decreased dopaminergic neuron number |
J:156717
|
|
small cerebellum |
J:156717
|
Fgf8tm1(cre)Itl/Fgf8+
Not Specified
|
no abnormal phenotype detected |
J:165806
|
Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
involves: CD-1
|
abnormal amnion morphology |
J:135128
|
|
abnormal developmental patterning |
J:135128
|
|
abnormal heart tube morphology |
J:135128
|
|
abnormal mesoderm development |
J:135128
|
|
abnormal pharyngeal arch morphology |
J:135128
|
|
abnormal primitive streak morphology |
J:135128
|
|
absent primitive node |
J:135128
|
|
decreased embryo size |
J:135128
|
|
open neural tube |
J:135128
|
Fgf8tm1.1Mrt/Fgf8tm1.1Mrt
involves: 129P2/OlaHsd
|
absent cerebellum |
J:45909
|
|
absent inferior colliculus |
J:45909
|
|
absent olfactory bulb |
J:45909
|
|
neonatal lethality, complete penetrance |
J:45909
|
Fgf8tm1.1Mrt/Fgf8tm1.2Mrt
involves: 129P2/OlaHsd
|
abnormal craniofacial development |
J:45909
|
|
abnormal heart development |
J:45909
|
|
abnormal hypothalamus morphology |
J:178252
|
|
abnormal midbrain morphology |
J:45909
|
|
abnormal pituitary gland morphology |
J:178252
|
|
abnormal rostral-caudal axis patterning |
J:45909
|
|
absent cerebellum |
J:45909
|
|
absent inferior colliculus |
J:45909
|
|
decreased embryo size |
J:45909
|
|
prenatal lethality, incomplete penetrance |
J:45909
|
|
small embryonic telencephalon |
J:45909
|
|
syndactyly |
J:45909
|
Fgf8tm1.1Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd
|
decreased neuron apoptosis |
J:111586
|
Fgf8tm1.1Mrt/Fgf8tm1.4Mrt
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd
|
increased neuron apoptosis |
J:111586
|
Fgf8tm1.2Mrt/Fgf8tm1.2Mrt
involves: 129P2/OlaHsd
|
abnormal allantois morphology |
J:56519
|
|
abnormal amnion morphology |
J:56519
|
|
abnormal chorion morphology |
J:56519
|
|
abnormal ectoderm development |
J:56519
|
|
abnormal embryonic epiblast morphology |
J:56519
|
|
abnormal mesoderm development |
J:45909,
J:56519
|
|
abnormal primitive streak elongation |
J:56519
|
|
absent heart |
J:45909,
J:56519
|
|
absent primitive node |
J:56519
|
|
absent somites |
J:56519
|
|
decreased embryo size |
J:45909
|
|
embryonic lethality during organogenesis, complete penetrance |
J:45909
|
Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
involves: 129P2/OlaHsd
|
no abnormal phenotype detected |
J:45909
|
Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd
|
abnormal cochlear sensory epithelium morphology |
J:122378
|
|
abnormal forebrain development |
J:122378
|
|
abnormal patterning of the organ of Corti |
J:122378
|
|
abnormal pillar cell differentiation |
J:122378
|
|
abnormal pillar cell morphology |
J:122378
|
|
absent pillar cells |
J:122378
|
|
perinatal lethality, complete penetrance |
J:122378
|
Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
Tg(Nes-cre)1Atp/0
involves: 129P2/OlaHsd * FVB/N
|
abnormal craniofacial development |
J:58999
|
|
abnormal craniofacial morphology |
J:58999
|
|
abnormal mandible morphology |
J:58999
|
|
abnormal maxilla morphology |
J:58999
|
|
abnormal trigeminal nerve morphology |
J:58999
|
|
absent incus |
J:58999
|
|
absent Meckel's cartilage |
J:58999
|
|
absent molars |
J:58999
|
|
decreased tongue size |
J:58999
|
|
increased apoptosis |
J:58999
|
|
neonatal lethality, complete penetrance |
J:58999
|
|
small first pharyngeal arch |
J:58999
|
Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd
|
abnormal allantois morphology |
J:56519
|
|
abnormal amnion morphology |
J:56519
|
|
abnormal chorion morphology |
J:56519
|
|
abnormal ectoderm development |
J:56519
|
|
abnormal embryonic epiblast morphology |
J:56519
|
|
abnormal mesoderm development |
J:56519
|
|
abnormal primitive streak elongation |
J:56519
|
|
absent heart |
J:56519
|
|
absent primitive node |
J:56519
|
|
absent somites |
J:56519
|
|
embryonic lethality during organogenesis, complete penetrance |
J:56519
|
Fgf8tm1.3Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
|
abnormal aortic arch morphology |
J:110620
|
Fgf8tm1.3Mrt/Fgf8+
Six1tm1(cre)Xli/Six1+
involves: 129 * 129P2/OlaHsd * C57BL/6
|
abnormal cardiac outflow tract development |
J:172023
|
|
cervical aortic arch |
J:172023
|
|
interrupted aortic arch |
J:172023
|
Fgf8tm1.3Mrt/Fgf8tm1.3Mrt
involves: 129P2/OlaHsd
|
no abnormal phenotype detected |
J:45909
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd
|
increased neuron apoptosis |
J:111586
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
|
abnormal heart tube morphology |
J:109474
|
|
absent cardiac outflow tract |
J:109474
|
|
absent heart right ventricle |
J:109474
|
|
dilated heart atrium |
J:109474
|
|
dilated heart left ventricle |
J:109474
|
|
embryonic lethality during organogenesis, complete penetrance |
J:109474
|
|
pharyngeal arch hypoplasia |
J:109474
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
|
abnormal aortic arch morphology |
J:110620
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd
|
abnormal digit development |
J:66266
|
|
abnormal forelimb stylopod morphology |
J:104411
|
|
abnormal forelimb zeugopod morphology |
J:66266,
J:104411
|
|
abnormal hindlimb stylopod morphology |
J:66266,
J:104411
|
|
abnormal hindlimb zeugopod morphology |
J:66266,
J:104411
|
|
abnormal limb development |
J:104411
|
|
absent deltoid tuberosity |
J:104411
|
|
absent radius |
J:66266
|
|
oligodactyly |
J:104411
|
|
small limb buds |
J:66266
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(T-cre)1Lwd/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
|
abnormal kidney development |
J:101175
|
|
abnormal ureteric bud morphology |
J:101175
|
|
absent renal glomerulus |
J:101175
|
|
hindlimb oligodactyly |
J:101175
|
|
impaired branching involved in ureteric bud morphogenesis |
J:101175
|
|
increased kidney apoptosis |
J:101175
|
|
kidney failure |
J:101175
|
|
neonatal lethality, complete penetrance |
J:101175
|
|
normal
skeleton phenotype |
J:101175
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tbx1-cre)1Joe/0
involves: 129P2/OlaHsd
|
abnormal cardiovascular system morphology |
J:88814
|
|
abnormal heart development |
J:88814
|
|
abnormal internal carotid artery morphology |
J:88814
|
|
abnormal thymus morphology |
J:88814
|
|
abnormal vascular smooth muscle morphology |
J:88814
|
|
aortic dissection |
J:88814
|
|
atrial septal defect |
J:88814
|
|
normal
cardiovascular system phenotype |
J:88814
|
|
double outlet right ventricle |
J:88814
|
|
perimembraneous ventricular septal defect |
J:88814
|
|
perinatal lethality, incomplete penetrance |
J:88814
|
|
persistent truncus arteriosus |
J:88814
|
|
small thymus |
J:88814
|
|
transposition of great arteries |
J:88814
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tnnt2-cre)5Blh/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA/2
|
normal
cardiovascular system phenotype |
J:109474
|
Fgf8tm1.3Mrt/Fgf8tm2Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd
|
abnormal heart development |
J:109474
|
|
abnormal heart morphology |
J:109474
|
|
abnormal neural crest cell morphology |
J:109474
|
|
abnormal pharyngeal arch mesenchyme morphology |
J:109474
|
|
abnormal pharyngeal arch morphology |
J:109474
|
|
abnormal splanchnic mesoderm morphology |
J:109474
|
|
decreased mitotic index |
J:109474
|
|
normal
mortality/aging |
J:109474
|
Fgf8tm1.4Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
|
abnormal aortic arch morphology |
J:110620
|
Fgf8tm1.4Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd
|
abnormal allantois morphology |
J:56519
|
|
abnormal amnion morphology |
J:56519
|
|
abnormal chorion morphology |
J:56519
|
|
abnormal ectoderm development |
J:56519
|
|
abnormal embryonic epiblast morphology |
J:56519
|
|
abnormal mesoderm development |
J:56519
|
|
abnormal primitive streak elongation |
J:56519
|
|
absent heart |
J:56519
|
|
absent primitive node |
J:56519
|
|
absent somites |
J:56519
|
|
embryonic lethality during organogenesis, complete penetrance |
J:56519
|
Fgf8tm1b(KOMP)Wtsi/Fgf8tm1b(KOMP)Wtsi
C57BL/6N-Fgf8tm1b(KOMP)Wtsi/H
|
embryonic lethality prior to tooth bud stage |
J:211773
|
|
preweaning lethality, complete penetrance |
J:211773
|
Fgf8tm1Jyhl/Fgf8tm1Jyhl
involves: CD-1
|
abnormal cardiogenic mesoderm morphology |
J:135128
|
|
abnormal mesoderm development |
J:135128
|
|
abnormal neural fold formation |
J:135128
|
|
abnormal primitive streak morphology |
J:135128
|
|
abnormal somite development |
J:135128
|
|
absent mesoderm |
J:135128
|
Fgf8tm1Moon/Fgf8tm1Moon
Mesp1tm2(cre)Ysa/Mesp1+
involves: C57BL/6NCrlj * CBA/JNCrlj
|
aberrant origin of the right subclavian artery |
J:170879
|
|
abnormal cardiac epithelial to mesenchymal transition |
J:170879
|
|
abnormal cardiac neural crest cell migration |
J:170879
|
|
abnormal cardiac outflow tract development |
J:170879
|
|
abnormal cardiovascular development |
J:170879
|
|
abnormal common carotid artery morphology |
J:170879
|
|
abnormal fourth pharyngeal arch artery morphology |
J:170879
|
|
abnormal pharyngeal arch artery morphology |
J:170879
|
|
abnormal sixth pharyngeal arch artery morphology |
J:170879
|
|
abnormal third pharyngeal arch artery morphology |
J:170879
|
|
decreased heart right ventricle size |
J:170879
|
|
double outlet right ventricle |
J:170879
|
|
right aortic arch |
J:170879
|
|
ventricular septal defect |
J:170879
|
Fgf8tm1Mrc/Fgf8tm1Moon
Hoxa3tm1(cre)Moon/Hoxa3+
involves: 129/Sv * C57BL/6
|
abnormal coronary vessel morphology |
J:87304
|
|
abnormal fourth pharyngeal arch artery morphology |
J:87304
|
|
abnormal neural crest cell apoptosis |
J:87304
|
|
abnormal parathyroid gland morphology |
J:87304
|
|
abnormal pharyngeal arch artery morphology |
J:87304
|
|
abnormal truncus arteriosus septation |
J:87304
|
|
absent parathyroid glands |
J:87304
|
|
bicuspid aortic valve |
J:87304
|
|
ectopic parathyroid gland |
J:87304
|
|
ectopic thymus |
J:87304
|
|
enlarged third pharyngeal arch artery |
J:87304
|
|
neonatal lethality, incomplete penetrance |
J:87304
|
|
parathyroid hypoplasia |
J:87304
|
|
thymus hypoplasia |
J:87304
|
Fgf8tm1Mrc/Fgf8tm1Moon
Tfap2atm1(cre)Moon/Tfap2a+
involves: 129/Sv * C57BL/6
|
abnormal blood vessel morphology |
J:87304
|
|
abnormal coronary artery morphology |
J:87304
|
|
abnormal craniofacial morphology |
J:87304
|
|
abnormal fourth pharyngeal arch artery morphology |
J:87304
|
|
abnormal neural crest cell apoptosis |
J:87304
|
|
abnormal pharyngeal arch artery morphology |
J:87304
|
|
abnormal subclavian artery morphology |
J:87304
|
|
absent fourth pharyngeal arch artery |
J:87304
|
|
absent sixth pharyngeal arch artery |
J:87304
|
|
enlarged third pharyngeal arch artery |
J:87304
|
|
fourth pharyngeal arch artery hypoplasia |
J:87304
|
|
interrupted aortic arch, type b |
J:87304
|
|
pharyngeal arch hypoplasia |
J:87304
|
|
postnatal lethality, complete penetrance |
J:87304
|
|
prenatal lethality, incomplete penetrance |
J:87304
|
|
retroesophageal right subclavian artery |
J:87304
|
|
right aortic arch |
J:87304
|
Fgf8tm1Mrc/Fgf8tm1Mrc
Not Specified
|
prenatal lethality |
J:66265
|
Fgf8tm1Mrc/Fgf8tm2Moon
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Not Specified
|
normal
cardiovascular system phenotype |
J:143444
|
Fgf8tm1Mrc/Fgf8tm2Moon
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv * Black Swiss * C57BL/6
|
abnormal cardiac epithelial to mesenchymal transition |
J:143444
|
|
abnormal cardiac outflow tract development |
J:143444
|
|
abnormal conotruncal ridge morphology |
J:143444
|
|
persistent truncus arteriosus |
J:143444
|
Fgf8tm1Mrc/Fgf8tm2Mrc
Not Specified
|
no abnormal phenotype detected |
J:66265
|
Fgf8tm1Mrc/Fgf8tm2Mrc
Hoxa3tm1(cre)Moon/Hoxa3+
involves: 129/Sv * C57BL/6
|
abnormal coronary vessel morphology |
J:87304
|
|
abnormal fourth pharyngeal arch artery morphology |
J:87304
|
|
abnormal neural crest cell apoptosis |
J:87304
|
|
abnormal parathyroid gland morphology |
J:87304
|
|
abnormal pharyngeal arch artery morphology |
J:87304
|
|
abnormal truncus arteriosus septation |
J:87304
|
|
absent parathyroid glands |
J:87304
|
|
bicuspid aortic valve |
J:87304
|
|
ectopic parathyroid gland |
J:87304
|
|
ectopic thymus |
J:87304
|
|
enlarged third pharyngeal arch artery |
J:87304
|
|
neonatal lethality, incomplete penetrance |
J:87304
|
|
parathyroid hypoplasia |
J:87304
|
|
thymus hypoplasia |
J:87304
|
Fgf8tm1Mrc/Fgf8tm2Mrc
Tfap2atm1(cre)Moon/Tfap2a+
involves: 129/Sv * C57BL/6
|
abnormal blood vessel morphology |
J:87304
|
|
abnormal coronary artery morphology |
J:87304
|
|
abnormal craniofacial morphology |
J:87304
|
|
abnormal fourth pharyngeal arch artery morphology |
J:87304
|
|
abnormal neural crest cell apoptosis |
J:87304
|
|
abnormal pharyngeal arch artery morphology |
J:87304
|
|
abnormal subclavian artery morphology |
J:87304
|
|
absent fourth pharyngeal arch artery |
J:87304
|
|
absent sixth pharyngeal arch artery |
J:87304
|
|
enlarged third pharyngeal arch artery |
J:87304
|
|
fourth pharyngeal arch artery hypoplasia |
J:87304
|
|
interrupted aortic arch, type b |
J:87304
|
|
pharyngeal arch hypoplasia |
J:87304
|
|
postnatal lethality, complete penetrance |
J:87304
|
|
prenatal lethality, incomplete penetrance |
J:87304
|
|
retroesophageal right subclavian artery |
J:87304
|
|
right aortic arch |
J:87304
|
Fgf8tm1Mrc/Fgf8tm2Mrc
Tg(Rarb-cre)1Mrc/0
Not Specified
|
abnormal digit morphology |
J:66265
|
|
abnormal limb bone morphology |
J:66265
|
|
abnormal limb morphology |
J:66265
|
Fgf8tm1Mrc/Fgf8tm3Mrc
involves: 129 * C57BL/6
|
abnormal cardiovascular system morphology |
J:87304
|
|
abnormal craniofacial morphology |
J:87304
|
|
abnormal neural crest cell apoptosis |
J:87304
|
|
abnormal truncus arteriosus septation |
J:87304
|
|
cyanosis |
J:87304
|
|
edema |
J:87304
|
|
fetal growth retardation |
J:87304
|
|
neonatal lethality, complete penetrance |
J:87304
|
|
third pharyngeal arch artery hypoplasia |
J:87304
|
Fgf8tm2.1Jyhl/Fgf8+
B6.129S6-Fgf8tm2.1Jyhl
|
decreased body weight |
J:156717
|
|
normal
mortality/aging |
J:156717
|
Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
B6.129S6-Fgf8tm2.1Jyhl
|
postnatal lethality, incomplete penetrance |
J:156717
|
Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
involves: 129S6/SvEvTac * CD-1
|
decreased body weight |
J:156717
|
|
normal
nervous system phenotype |
J:156717
|
|
postnatal lethality |
J:156717
|
Fgf8tm2Moon/Fgf8tm1Mrc
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv
|
abnormal heart right ventricle morphology |
J:109475
|
|
abnormal truncus arteriosus septation |
J:109475
|
|
embryonic lethality during organogenesis, incomplete penetrance |
J:109475
|
|
increased apoptosis |
J:109475
|
|
persistent truncus arteriosus |
J:109475
|
|
small pharyngeal arch |
J:109475
|
Fgf8tm2Moon/Fgf8tm1Mrc
Mesp1tm2(cre)Ysa/Mesp1+
involves: C57BL/6 * CBA
|
abnormal cardiac outflow tract development |
J:109475
|
|
abnormal heart tube morphology |
J:109475
|
|
bicuspid aortic valve |
J:109475
|
|
bicuspid pulmonary valve |
J:109475
|
|
common atrium |
J:109475
|
|
common ventricle |
J:109475
|
|
decreased cell proliferation |
J:109475
|
|
decreased heart right ventricle size |
J:109475
|
|
edema |
J:109475
|
|
embryonic lethality during organogenesis, incomplete penetrance |
J:109475
|
|
increased apoptosis |
J:109475
|
|
pericardial effusion |
J:109475
|
|
transposition of great arteries |
J:109475
|
Fgf8tm2Moon/Fgf8tm1Mrc
Tg(Mef2c-cre)2Blk/0
Not Specified
|
double outlet right ventricle |
J:109475
|
|
transposition of great arteries |
J:109475
|
Fgf8tm2Mrc/Fgf8tm2Mrc
Not Specified
|
no abnormal phenotype detected |
J:66265
|
Fgf8tm2Mrt/Fgf8+
involves: 129 * C57BL/6J * DBA/2J
|
nervous system phenotype |
J:207892
|
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