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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gcgr
glucagon receptor
MGI:99572
49 phenotypes from 4 alleles in 5 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Gcgrtm1(GCGR)Kasu/Gcgrtm1(GCGR)Kasu
involves: 129S7/SvEvBrd * C57BL/6J
no abnormal phenotype detected J:58436
Gcgrtm1Jcp/Gcgrtm1Jcp
DBA/1LacJ-Gcgrtm1Jcp
abnormal exocrine gland morphology J:176507
abnormal pancreatic acinar cell morphology J:176507
abnormal pancreatic alpha cell differentiation J:176507
abnormal pancreatic alpha cell morphology J:176507
abnormal pancreatic islet morphology J:176507
decreased abdominal adipose tissue amount J:176507
decreased body weight J:176507
decreased circulating glucose level J:176507
decreased circulating insulin level J:176507
decreased liver weight J:176507
decreased subcutaneous adipose tissue amount J:176507
decreased susceptibility to hepatic steatosis J:176507
decreased susceptibility to weight gain J:176507
enlarged pancreas J:176507
enlarged pancreatic islets J:176507
normal homeostasis/metabolism phenotype J:73926
increased circulating glucagon level J:73926, J:176507
increased glucagonoma incidence J:176507
increased pancreas tumor incidence J:176507
increased pancreatic beta cell proliferation J:176507
pancreatic islet hyperplasia J:176507
Gcgrtm1Mjch/Gcgrtm1Mjch
involves: 129 * C57BL/6J * SJL
abnormal pancreatic alpha cell morphology J:208604
abnormal pancreatic alpha cell physiology J:208604
abnormal pancreatic beta cell morphology J:208604
decreased carbon dioxide production J:216393
decreased circulating insulin level J:208604
decreased food intake J:216393
decreased oxygen consumption J:216393
decreased susceptibility to diet-induced non-insulin dependent diabetes J:216393
decreased susceptibility to diet-induced obesity J:216393
hypoactivity J:216393
improved glucose tolerance J:208604
increased bile salt level J:208604
increased circulating glucagon level J:208604
increased glucagon secretion J:208604
increased insulin sensitivity J:208604
increased pancreas weight J:208604
increased pancreatic alpha cell number J:208604
Gcgrtm1Mjch/Gcgrtm1Mjch
involves: 129/Sv * C57BL/6J * SJL
decreased brown adipose tissue amount J:81772
decreased circulating glucose level J:81772
decreased circulating leptin level J:81772
decreased gonadal fat pad weight J:81772
decreased interscapular fat pad weight J:81772
decreased litter size J:81772
decreased total body fat amount J:81772
decreased triglyceride level J:81772
hypoglycemia J:81772
improved glucose tolerance J:81772
increased body mass index J:81772
increased circulating glucagon level J:81772
increased circulating LDL cholesterol level J:81772
pancreatic islet hyperplasia J:81772
postnatal lethality, incomplete penetrance J:81772
prenatal lethality, incomplete penetrance J:81772
Gcgrtm2.1Mjch/Gcgrtm2.1Mjch
Tg(Alb-cre)21Mgn/0
involves: C57BL/6 * DBA * SJL
abnormal glucose homeostasis J:208604
abnormal pancreatic alpha cell physiology J:208604
abnormal pancreatic beta cell morphology J:208604
decreased circulating glucose level J:208604
decreased circulating insulin level J:208604
hypoglycemia J:208604
improved glucose tolerance J:208604
increased bile salt level J:208604
increased circulating glucagon level J:208604
increased insulin sensitivity J:208604
increased pancreas weight J:208604
increased pancreatic alpha cell number J:208604

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory