93 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dmp1m1Btlr/Dmp1m1Btlr Ptpn11m1Btlr/Ptpn11m1Btlr Sdad1m1Btlr/Sdad1m1Btlr C57BL/6J-Dmp1m1Btlr Sdad1m1Btlr Ptpn11m1Btlr/Btlr	decreased bone mineral density	J:309727
	short tibia	J:309727
Egfrwa2/Egfrwa2 Ptpn11tm1Paw/Ptpn11+ involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6	abnormal breathing pattern	J:75413
	abnormal hair follicle development	J:75413
	abnormal hair follicle morphology	J:75413
	abnormal hair follicle orientation	J:75413
	abnormal hair growth	J:75413
	abnormal intestine morphology	J:75413
	abnormal lung development	J:75413
	abnormal muscle morphology	J:75413
	abnormal skin condition	J:75413
	atelectasis	J:75413
	cachexia	J:75413
	decreased hair follicle number	J:75413
	decreased subcutaneous adipose tissue amount	J:75413
	dry skin	J:75413
	epidermal atrophy	J:75413
	eyelids open at birth	J:75413
	flaky skin	J:75413
	intestinal hypoperistalsis	J:75413
	postnatal growth retardation	J:75413
	postnatal lethality, incomplete penetrance	J:75413
	thick pulmonary interalveolar septum	J:75413
	thin epidermis	J:75413
	thin skin	J:75413
	waved hair	J:75413
Egfrwa2/Egfrwa2 Ptpn11tm1Rbn/Ptpn11+ involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt	abnormal impulse conducting system conduction	J:60750
	aortic valve regurgitation	J:60750
	aortic valve stenosis	J:60750
	congestive heart failure	J:60750
	enlarged semilunar valve	J:60750
	eyelids open at birth	J:60750
	increased left ventricle diastolic pressure	J:60750
	increased left ventricle systolic pressure	J:60750
	increased systemic arterial blood pressure	J:60750
	myocardium hypertrophy	J:60750
	perinatal lethality, incomplete penetrance	J:60750
	prolonged PR interval	J:60750
	prolonged QRS complex duration	J:60750
	prolonged QT interval	J:60750
	prolonged RR interval	J:60750
	prolonged ST segment	J:60750
	thick aortic valve	J:60750
	thick pulmonary valve	J:60750
Egr2tm2(cre)Pch/Egr2+ Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/? Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal myelination	J:207470
Egr2tm2(cre)Pch/Egr2+ Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/? Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	hypermyelination	J:207470
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns H2az2Tg(Wnt1-cre)11Rth/H2az2+ B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor H2az2Tg(Wnt1-cre)11Rth	decreased cardiac neural crest cell number	J:150835
	impaired cranial neural crest cell differentiation	J:150835
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/? Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm Tg(Dhh-cre)1Mejr/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal myelination	J:207470
Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/? Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm Tg(Dhh-cre)1Mejr/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	hypermyelination	J:207470
Krastm4Tyj/Krastm4Tyj Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Six3-cre)69Frty/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal cone electrophysiology	J:174095
	abnormal rod electrophysiology	J:174095
	decreased a-wave amplitude	J:174095
	decreased b-wave amplitude	J:174095
	normal vision/eye phenotype	J:174095
Mapk1tm1Melo/Mapk1+ Tg(Myh7-Ptpn11*Q79R)11Rbns/0 involves: 129S2/SvPas * FVB/N	normal cardiovascular system phenotype	J:123963
	normal respiratory system phenotype	J:123963
Mapk3tm1Gpg/Mapk3tm1Gpg Tg(Myh7-Ptpn11*Q79R)11Rbns/0 involves: 129/Sv * FVB/N	normal cardiovascular system phenotype	J:123963
	normal respiratory system phenotype	J:123963
Mpzl1em1Ambt/Mpzl1em1Ambt Ptpn11tm4.2Bgn/Ptpn11tm4.2Bgn B6.Cg-Mpzl1em1Ambt Ptpn11tm4.2Bgn	normal cardiovascular system phenotype	J:301775
	normal growth/size/body region phenotype	J:301775
	slow postnatal weight gain	J:301775
Ptentm1Hwu/Ptentm1Hwu Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Six3-cre)69Frty/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	optic nerve atrophy	J:174095
	retina degeneration	J:174095
	retina ganglion cell degeneration	J:174095
	retina outer nuclear layer degeneration	J:174095
	thin retina ganglion layer	J:174095
	thin retina inner nuclear layer	J:174095
	thin retina outer nuclear layer	J:174095
Ptpn11tm1Gsf/Ptpn11tm1Gsf Stat3tm1Vpo/Stat3tm1Vpo Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	increased circulating alanine transaminase level	J:172422
	increased incidence of tumors by chemical induction	J:172422
	liver inflammation	J:172422
Ptpn11tm1Gsf/Ptpn11tm1Gsf Stat3tm1Xyfu/Stat3tm1Xyfu Tg(Six3-cre)69Frty/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	retina degeneration	J:174095
	retina ganglion cell degeneration	J:174095
	retina outer nuclear layer degeneration	J:174095
	thin retina ganglion layer	J:174095
	thin retina inner nuclear layer	J:174095
	thin retina outer nuclear layer	J:174095
	thin retina outer plexiform layer	J:174095
Tg(CAG-cat,-Ptpn11)1Rbns/0 Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6 * FVB/N	normal cardiovascular system phenotype	J:142212
Tg(Myh6-Ptpn11)75Rbns/0 FVB.Cg-Tg(Myh6-Ptpn11)75Rbns	normal cardiovascular system phenotype	J:123963
Tg(Myh6-Ptpn11*Q79R)197Rbns/0 FVB.Cg-Tg(Myh6-Ptpn11*Q79R)197Rbns	normal cardiovascular system phenotype	J:123963
Tg(Myh6-Ptpn11*Q510E)#Krnz/0 FVB/N-Tg(Myh6-Ptpn11*Q510E)#Krnz	normal cardiovascular system phenotype	J:181656
Tg(Myh7-Ptpn11)294Rbns/0 FVB.Cg-Tg(Myh7-Ptpn11)294Rbns	normal cardiovascular system phenotype	J:123963
Tg(Myh7-Ptpn11*Q79R)11Rbns/0 FVB.Cg-Tg(Myh7-Ptpn11*Q79R)11Rbns	abnormal atrial thrombosis	J:123963
	abnormal cardiovascular system physiology	J:123963
	abnormal interventricular groove morphology	J:123963
	decreased cardiac muscle contractility	J:123963
	dilated heart atrium	J:123963
	dilated heart ventricle	J:123963
	increased heart weight	J:123963
	increased lung weight	J:123963
	premature death	J:123963
	thick ventricular wall	J:123963
	ventricular cardiomyopathy	J:123963
	ventricular septal defect	J:123963
Tg(Myh7-Ptpn11*Q510E)#Krnz/0 FVB/N-Tg(Myh7-Ptpn11*Q510E)#Krnz	abnormal fetal cardiomyocyte morphology	J:181656
	abnormal heart echocardiography feature	J:181656, J:222124
	abnormal heart morphology	J:181656
	abnormal heart ventricle shape	J:181656
	abnormal interventricular groove morphology	J:181656
	abnormal myocardial fiber morphology	J:222124
	abnormal myocardial fiber physiology	J:222124
	cardiac hypertrophy	J:181656, J:222124
	cardiac interstitial fibrosis	J:181656
	cardiomyopathy	J:181656
	decreased cardiac muscle contractility	J:181656
	increased cardiac muscle contractility	J:222124
	increased heart atrium size	J:181656
	increased heart left atrium size	J:181656
	increased heart weight	J:181656, J:222124
	increased myocardial fiber size	J:181656, J:222124
	thick interventricular septum	J:181656
	ventricular septal defect	J:181656