Irs1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irs1
insulin receptor substrate 1
MGI:99454

67 phenotypes from 11 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Irs1^em1(IMPC)H/Irs1⁺ C57BL/6NTac-Irs1^em1(IMPC)H/H	increased freezing behavior	J:211773
Irs1^em1(IMPC)H/Irs1⁺ C57BL/6NTac-Irs1^em1(IMPC)H/H	increased mean platelet volume	J:211773
Irs1^em1(IMPC)H/Irs1^em1(IMPC)H C57BL/6NTac-Irs1^em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Irs1^m1Btlr/Irs1^m1Btlr C57BL/6J-Irs1^m1Btlr	decreased body weight	J:267531
Irs1^m1Btlr/Irs1^m1Btlr C57BL/6J-Irs1^m1Btlr	increased circulating insulin level	J:267531
Irs1^m2Btlr/Irs1^m2Btlr C57BL/6J-Irs1^m2Btlr	decreased body weight	J:267532
Irs1^mpc178H/Irs1^mpc178H involves: BALB/c * C3H/HeH * C57BL/6J	decreased bone mineral density	J:234901
	postnatal growth retardation	J:234901
Irs1^Sml/Irs1⁺ C3.Cg-Irs1^Sml H2^b/GrsrJ	abnormal femur morphology	J:163661
	decreased body weight	J:163661
	decreased bone mineral density	J:163661
	decreased long bone epiphyseal plate size	J:163661
	decreased total body fat amount	J:163661
	increased circulating insulin level	J:163661
	short femur	J:163661
Irs1^Sml/Irs1^Sml C3.Cg-Irs1^Sml H2^b/GrsrJ	abnormal bone mineralization	J:163661
	abnormal bone structure	J:163661
	abnormal femur morphology	J:163661
	abnormal tail morphology	J:163661
	decreased body size	J:163661
	decreased body weight	J:163661
	decreased bone mineral density	J:163661
	decreased circulating glucose level	J:163661
	decreased long bone epiphyseal plate size	J:163661
	decreased osteoblast proliferation	J:163661
	decreased percent body fat/body weight	J:163661
	decreased trabecular bone thickness	J:163661
	impaired glucose tolerance	J:163661
	impaired osteoblast differentiation	J:163661
	increased circulating insulin level	J:163661
	increased or absent threshold for auditory brainstem response	J:163661
	increased osteoblast cell number	J:163661
	increased osteoclast cell number	J:163661
	insulin resistance	J:163661
	proportional dwarf	J:163661
	short femur	J:163661
	short tail	J:163661
	thin tail	J:163661
Irs1^smla/Irs1^smla involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6	normal mortality/aging	J:164568
Irs1^smla/Irs1^smla involves: 129S2/SvPas * C57BL/6J	decreased body size	J:164568
	postnatal lethality	J:164568
	premature death	J:164568
Irs1^tm1Jos/Irs1^tm1Jos involves: 129S2/SvPas * C57BL/6	decreased birth weight	J:21374
	decreased body size	J:21374
	decreased body weight	J:21374
	impaired glucose tolerance	J:21374
	increased circulating insulin level	J:21374
	insulin resistance	J:21374
	postnatal growth retardation	J:80976
	normal skeleton phenotype	J:21374
	normal vision/eye phenotype	J:98107
Irs1^tm1Mfw/Irs1^tm1Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	impaired glucose tolerance	J:137845
Irs1^tm1Tka/Irs1^tm1Tka involves: C57BL/6 * CBA	abnormal bone healing	J:89532
	abnormal cell differentiation	J:68004
	abnormal lipid level	J:47029
	abnormal long bone epiphyseal plate proliferative zone	J:89532
	abnormal long bone hypertrophic chondrocyte zone	J:89532
	abnormal osteoblast physiology	J:61479
	abnormal osteoclast differentiation	J:61479
	abnormal osteoclast physiology	J:61479
	abnormal trabecular bone morphology	J:61479
	abnormal vascular wound healing	J:99746
	decreased body weight	J:47029
	decreased bone mineral content	J:89532
	decreased bone mineral density	J:61479
	decreased bone mineral density of femur	J:61479
	decreased cell proliferation	J:89532
	decreased chondrocyte number	J:61479
	decreased circulating HDL cholesterol level	J:47029
	decreased compact bone thickness	J:61479
	decreased insulin secretion	J:65485
	decreased long bone epiphyseal plate size	J:61479
	decreased osteoblast cell number	J:61479
	decreased vasodilation	J:99746
	normal homeostasis/metabolism phenotype	J:61479
	hypertension	J:47029
	impaired lipolysis	J:47029
	increased circulating free fatty acids level	J:99746
	increased circulating insulin level	J:61479
	increased circulating triglyceride level	J:47029, J:99746
	increased systemic arterial diastolic blood pressure	J:47029
	increased systemic arterial systolic blood pressure	J:47029, J:99746
	insulin resistance	J:99746
	short femur	J:61479
	short tibia	J:61479
Irs1^tm1Tka/Irs1^tm1Tka Not Specified	abnormal glucose homeostasis	J:21373
	abnormal postnatal growth/weight/body size	J:21373
	decreased body weight	J:21373
	decreased fetal weight	J:21373
	fetal growth retardation	J:21373
	normal homeostasis/metabolism phenotype	J:21373
	increased circulating insulin level	J:21373
	insulin resistance	J:21373
	postnatal growth retardation	J:21373
Irs1^tm2.1Mfw/Irs1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	abnormal pancreatic beta cell morphology	J:156999
	increased circulating insulin level	J:156999
Irs1^tm2.1Mfw/Irs1^tm2.1Mfw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	abnormal pancreatic beta cell morphology	J:156999
	decreased body length	J:156999
	decreased body weight	J:156999
	impaired glucose tolerance	J:156999
	increased circulating insulin level	J:156999
	insulin resistance	J:156999
Irs1^tm2Tka/Irs1^tm2Tka Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * C57BL/6 * DBA	normal homeostasis/metabolism phenotype	J:137846
	increased circulating insulin level	J:137846
	insulin resistance	J:137846

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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