Ifit2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ifit2
interferon-induced protein with tetratricopeptide repeats 2
MGI:99449

17 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ifit2^tm1.1Ebsb/Ifit2^tm1.1Ebsb B6.129P2(C)-Ifit2^tm1.1Ebsb	enhanced humoral immune response	J:233986
	increased IgE level	J:233986
	increased IgG1 level	J:233986
	increased IgG3 level	J:233986
	increased IgM level	J:233986
Ifit2^tm1.1Ebsb/Ifit2^tm1.1Ebsb B6NCrl.129P2(C)-Ifit2^tm1.1Ebsb	decreased circulating interleukin-1 beta level	J:199862
	decreased circulating interleukin-6 level	J:199862
	decreased circulating interleukin-12b level	J:199862
	decreased circulating tumor necrosis factor level	J:199862
	decreased interleukin-6 secretion	J:199862
	decreased tumor necrosis factor secretion	J:199862
	increased susceptibility to bacterial infection induced morbidity/mortality	J:199862
Ifit2^tm1.1Tac/Ifit2⁺ involves: C57BL/6	increased susceptibility to Riboviria infection induced morbidity/mortality	J:195382
Ifit2^tm1.1Tac/Ifit2^tm1.1Tac involves: C57BL/6	ataxia	J:195382
	hindlimb paralysis	J:195382
	increased susceptibility to Riboviria infection	J:195382
	increased susceptibility to Riboviria infection induced morbidity/mortality	J:195382
	induced hyperactivity	J:195382

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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