155 phenotypes from 42 alleles in 30 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atp7a+/Atp7aMo-5J involves: C57BL/6J * DBA/2J	abnormal coat appearance	J:78379
	mosaic coat color	J:78379
Atp7aem1(IMPC)J/Y C57BL/6NJ-Atp7aem1(IMPC)J/Mmjax	abnormal coat/ hair morphology	J:211773
	abnormal coat/hair pigmentation	J:211773
	abnormal vocalization	J:211773
Atp7aem1(IMPC)J/Atp7aem1(IMPC)J C57BL/6NJ-Atp7aem1(IMPC)J/Mmjax	abnormal coat/hair pigmentation	J:211773
	abnormal vocalization	J:211773
Atp7aMo-1Pub/Y involves: 101 * C3H * T STOCK	prenatal lethality, complete penetrance	J:38977
Atp7aMo-2Acre/Y involves: 101 * C3H * T STOCK	postnatal lethality, complete penetrance	J:38977
Atp7aMo-2Btlr/Atp7a+ C57BL/6J-Atp7aMo-2Btlr	mosaic coat color	J:138687, J:188598
Atp7aMo-2Btlr/Y C57BL/6J-Atp7aMo-2Btlr	absent coat pigmentation	J:138687, J:188598
	normal pigmentation phenotype	J:138687
	postnatal lethality, complete penetrance	J:138687, J:188598
	prenatal lethality, incomplete penetrance	J:138687, J:188598
Atp7aMo-3Btlr/Y C57BL/6J-Atp7aMo-3Btlr	abnormal coat/hair pigmentation	J:153280, J:188598
	decreased brain copper level	J:188598
	decreased susceptibility to prion infection	J:188598
Atp7aMo-3Btlr/Atp7a+ C57BL/6J-Atp7aMo-3Btlr	normal integument phenotype	J:188598
Atp7aMo-3Btlr/Atp7aMo-3Btlr C57BL/6J-Atp7aMo-3Btlr	abnormal coat/hair pigmentation	J:153280, J:188598
Atp7aMo-4R/Y Not Specified	prenatal lethality, complete penetrance	J:13383
Atp7aMo-4R/Atp7a+ Not Specified	kinked vibrissae	J:13383
	mottled coat	J:13383
Atp7aMo-5J/Y involves: C57BL/6J * DBA/2J	abnormal coat/hair pigmentation	J:78379
	preweaning lethality, complete penetrance	J:78379
Atp7aMo-7ENURF/Y Not Specified	prenatal lethality, complete penetrance	J:38977
Atp7aMo-7R/Y Not Specified	prenatal lethality, complete penetrance	J:38977
Atp7aMo-8J/Y involves: C3HeB/FeJ * C57BL/6J	abnormal coat/hair pigmentation	J:16313
	diluted coat color	J:16313
	hindlimb paralysis	J:16313
	postnatal lethality	J:38978
	wavy vibrissae	J:16313
Atp7aMo-8J/Atp7a+ involves: C3HeB/FeJ * C57BL/6J	abnormal coat/hair pigmentation	J:16313
	diluted coat color	J:16313
	hindlimb paralysis	J:16313
	irregular coat pigmentation	J:16313
	mosaic coat color	J:16313
	wavy vibrissae	J:16313
Atp7aMo-8R/Y involves: 101 * C3H * T STOCK	prenatal lethality, complete penetrance	J:38977
Atp7aMo-9J/Y involves: C57BL/6J	prenatal lethality, complete penetrance	J:51010
Atp7aMo-9J/Atp7a+ involves: C57BL/6J	abnormal coat/hair pigmentation	J:51010
	curly vibrissae	J:51010
	mottled coat	J:51010
Atp7aMo-10H/Atp7a+ involves: 101/H * C3H/HeH	variegated coat color	J:16303
Atp7aMo-10H/Y involves: 101/H * C3H/HeH	absent coat pigmentation	J:16303
	curly vibrissae	J:16303
	impaired coordination	J:16303
	postnatal lethality, complete penetrance	J:16303
Atp7aMo-11H/Atp7a+ involves: 101/H * C3H/HeH	perinatal lethality, incomplete penetrance	J:16303
	variegated coat color	J:16303
Atp7aMo-11H/Y involves: 101/H * C3H/HeH	prenatal lethality, complete penetrance	J:16303, J:38977
Atp7aMo-12DFiOD/Y involves: 101 * C3H * T STOCK	prenatal lethality, complete penetrance	J:38977
Atp7aMo-12H/Y involves: 101/H * C3H/HeH	preweaning lethality, complete penetrance	J:16303
Atp7aMo-12H/Atp7a+ involves: 101/H * C3H/HeH	abnormal limb bone morphology	J:16303
	curly vibrissae	J:16303
	impaired balance	J:16303
	impaired coordination	J:16303
	variegated coat color	J:16303
Atp7aMo-13H/Y involves: 101/H * C3H/HeH	postnatal lethality, complete penetrance	J:12800
Atp7aMo-14H/Y Not Specified	prenatal lethality	J:34477
Atp7aMo-16H/Atp7a+ SWF	variegated coat color	J:69983
Atp7aMo-17H/Atp7a+ Not Specified	variegated coat color	J:69983
Atp7aMo-18H/Atp7a+ involves: 101/H	absent vibrissae	J:179962
	curly vibrissae	J:179962
	mottled coat	J:179962
Atp7aMo-18H/Y involves: 101/H	prenatal lethality	J:179962
Atp7aMo-blo/Y B6.Cg-Atp7aMo-blo/J	abnormal cartilage morphology	J:36378
	osteoarthritis	J:36378
	oxidative stress	J:105736
Atp7aMo-blo/Y involves: C57BL/6J	abnormal copper homeostasis	J:36268
	decreased liver copper level	J:36268
	increased intestine copper level	J:36268
	increased kidney copper level	J:36268
Atp7aMo-blo/Atp7a+ involves: C57BL/6J	abnormal copper homeostasis	J:36268
	abnormal ion homeostasis	J:36268
	decreased brain copper level	J:36268
	decreased liver copper level	J:36268
	increased kidney copper level	J:36268
Atp7aMo-blo/Y involves: C57BL/10	abnormal breathing pattern	J:5664
	abnormal pulmonary alveolus morphology	J:5664
	abnormal pulmonary interalveolar septum morphology	J:5664
	abnormal respiratory system physiology	J:5664
	dilated pulmonary alveolar duct	J:5664
	dilated respiratory conducting tube	J:5664
	enlarged lung	J:5664
	increased lung compliance	J:5664
	increased total lung capacity	J:5664
Atp7aMo-blo/Y Not Specified	abnormal aorta elastic fiber morphology	J:5516
	abnormal aorta morphology	J:5397, J:15796
	abnormal hindlimb morphology	J:13383
	abnormal noradrenaline level	J:5462
	aortic aneurysm	J:5397, J:5516, J:15796
	cachexia	J:5516
	coarse hair	J:5516
	curly vibrissae	J:13383
	decreased aorta elastin content	J:5516
	decreased body size	J:13383
	decreased locomotor activity	J:5462
	dilated aorta	J:5516
	dilated ascending aorta	J:15796
	diluted coat color	J:5462, J:13383, J:15796
	hemothorax	J:5516
	hunched posture	J:5516
	increased aortic weight	J:5397
	lethargy	J:5516
	male infertility	J:13383
	normal mortality/aging	J:38977
	premature death	J:13383
	priapism	J:5516
	tremors	J:5462
Atp7aMo-blo/Atp7a+ Not Specified	abnormal aorta elastic fiber morphology	J:5516
	abnormal aorta morphology	J:5516
	abnormal hindlimb morphology	J:13383
	aneurysm	J:5516
	aortic aneurysm	J:5397, J:5516
	cachexia	J:5516
	coarse hair	J:5516
	curly vibrissae	J:13383
	decreased aorta elastin content	J:5516
	decreased body size	J:13383
	dilated aorta	J:5516
	diluted coat color	J:13383
	hemoperitoneum	J:5516
	hemothorax	J:5516
	hunched posture	J:5516
	lethargy	J:5516
	normal reproductive system phenotype	J:13383
Atp7aMo-blo/? Not Specified	abnormal cell morphology	J:5880
	abnormal enzyme/coenzyme activity	J:5880
Atp7aMo-blo/Atp7aMo-blo Not Specified	abnormal hindlimb morphology	J:13383
	aortic aneurysm	J:5397
	curly vibrissae	J:13383
	decreased body size	J:13383
	diluted coat color	J:13383
	female infertility	J:13383
	premature death	J:13383
Atp7aMo-blo/Atp7aMo-br involves: C57BL	aortic aneurysm	J:5397
Atp7aMo-br/Y C57BL/6-Atp7aMo-br/J	abnormal enzyme/coenzyme activity	J:105736
Atp7aMo-br/Y involves: C57BL	abnormal liver copper level	J:5462
	abnormal noradrenaline level	J:5462
	decreased brain copper level	J:5462
	decreased circulating copper level	J:5462
	increased intestine copper level	J:5462
Atp7aMo-brJ/Y involves: C3H/HeJ * C57BL/6J	abnormal coat/hair pigmentation	J:33276
	abnormal gait	J:33276
	decreased liver copper level	J:33276
	increased intestine copper level	J:33276
	mottled coat	J:33276
	postnatal lethality	J:33276
	tremors	J:33276
Atp7aMo-brJ/Atp7a+ involves: C3H/HeJ * C57BL/6J	normal homeostasis/metabolism phenotype	J:33276
Atp7aMo-Btlr/Atp7a+ C57BL/6J-Atp7aMo-Btlr	mosaic coat color	J:133115, J:188598
Atp7aMo-Btlr/Y C57BL/6J-Atp7aMo-Btlr	perinatal lethality, complete penetrance	J:133115
	prenatal lethality, complete penetrance	J:188598
Atp7aMo-ca/Y Not Specified	prenatal lethality, complete penetrance	J:69983
Atp7aMo-ca/Atp7a+ Not Specified	curly vibrissae	J:69983
Atp7aMo-ca/Atp7aMo-ca Not Specified	prenatal lethality, complete penetrance	J:69983
Atp7aMo-dp2/Atp7a+ Not Specified	abnormal autopod morphology	J:13104
	abnormal coat/hair pigmentation	J:13104
	abnormal hair shaft melanin granule morphology	J:13104
	abnormal hair texture	J:13104
	abnormal skeleton morphology	J:13104
	abnormal vertebrae morphology	J:13104
	calcified tendon	J:13104
	curly vibrissae	J:13104
	impaired limb coordination	J:13104
	mottled coat	J:13104
	postnatal lethality	J:13104
	waved hair	J:13104
Atp7aMo-dp2/Y Not Specified	embryonic lethality during organogenesis, complete penetrance	J:13104
	pale yolk sac	J:13104
Atp7aMo-dp/Atp7a+ involves: 101/H * C3H/HeH	abnormal enzyme/coenzyme activity	J:220263
	curly vibrissae	J:220263
	decreased brain copper level	J:220263
	decreased noradrenaline level	J:220263
	variegated coat color	J:220263
Atp7aMo-dp/Y involves: 101/H * C3H/HeH	lethality throughout fetal growth and development	J:220263
Atp7aMo-dp/Atp7a+ Not Specified	abnormal skeleton morphology	J:12943
	aortic aneurysm	J:5397
	clubfoot	J:12943
	curly vibrissae	J:12943
	variegated coat color	J:12943
Atp7aMo-dp/Y Not Specified	abnormal limb bone morphology	J:12943
	abnormal pectoral girdle bone morphology	J:12943
	abnormal pelvic girdle bone morphology	J:12943
	abnormal rib morphology	J:12943
	lethality throughout fetal growth and development, incomplete penetrance	J:12943
	perinatal lethality, complete penetrance	J:12943
	wide ribs	J:12943
Atp7aMo-ml/Y C3Hf/He	abnormal coat/hair pigmentation	J:173226
	abnormal postnatal growth	J:40664
	abnormal survival	J:173226
	absent coat pigmentation	J:173226
	ataxia	J:40664
	cachexia	J:173226
	curly vibrissae	J:40664
	preweaning lethality, incomplete penetrance	J:173226
	tonic seizures	J:40664
Atp7aMo-ml/Atp7a+ C3Hf/He	variable depigmentation	J:173226
Atp7aMo-ml/Y involves: C3Hf/He	abnormal copper level	J:12745
	abnormal enzyme/coenzyme activity	J:12745
	abnormal large intestine morphology	J:12745
	abnormal postnatal growth	J:1132
	absent coat pigmentation	J:12745
	ataxia	J:12745
	curly vibrissae	J:12745
	decreased brain copper level	J:12745
	decreased brainstem copper level	J:12745
	decreased liver copper level	J:1132, J:12745
	decreased spleen weight	J:12745
	normal homeostasis/metabolism phenotype	J:1132
	increased intestine copper level	J:12745
	increased kidney copper level	J:12745
Atp7aMo-ml/Atp7a+ involves: C3Hf/He	curly vibrissae	J:12745
	decreased brain copper level	J:12745
	increased intestine copper level	J:12745
	variable depigmentation	J:12745
Atp7aMo-ml/Y involves: C3Hf/He * C57BL/6	preweaning lethality, incomplete penetrance	J:173226
Atp7aMo-ms/Y involves: CBA	abnormal renal tubule morphology	J:80157
	decreased kidney weight	J:80157
	decreased renal glomerulus number	J:80157
	increased kidney copper level	J:80157
Atp7aMo-ms/Y involves: CBA/Kw	abnormal awl hair morphology	J:14875
	abnormal copper homeostasis	J:14875
	abnormal zigzag hair morphology	J:14875
	curly vibrissae	J:14875
	decreased brain copper level	J:14875
	decreased circulating ceruloplasmin level	J:14875
	decreased liver copper level	J:14875
	hindlimb paresis	J:14875
	increased intestine copper level	J:14875
	postnatal lethality, complete penetrance	J:14875
	weight loss	J:14875
Atp7aMo-ms/Y Not Specified	abnormal copper level	J:168658
	abnormal vibrissa morphology	J:15062
	ataxia	J:168658
	curly vibrissae	J:15062
	decreased brain copper level	J:168658
	decreased liver copper level	J:168658
	diluted coat color	J:15062
	hindlimb paralysis	J:168658
	increased kidney copper level	J:168658
	increased neuron apoptosis	J:157286
	postnatal lethality, complete penetrance	J:15062
	tremors	J:168658
Atp7aMo-ms/Atp7a+ Not Specified	abnormal coat/ hair morphology	J:15062
	curly vibrissae	J:15062
Atp7aMo-N/Atp7a+ Not Specified	curly vibrissae	J:14901
	variegated coat color	J:14901
Atp7aMo-N/Y Not Specified	prenatal lethality, complete penetrance	J:14901
Atp7aMo-pew2J/Y involves: C57BL/6J * SJL/J	abnormal coat/hair pigmentation	J:16313
	diluted coat color	J:16313
	normal mortality/aging	J:16313
Atp7aMo-pew2J/Atp7a+ involves: C57BL/6J * SJL/J	abnormal coat/hair pigmentation	J:16313
	irregular coat pigmentation	J:16313
	mottled coat	J:16313
Atp7aMo-pew3J/Atp7a+ C;B6-Atp7aMo-pew3J/GrsrJ	abnormal coat/hair pigmentation	J:88763
Atp7aMo-pew3J/Y C;B6-Atp7aMo-pew3J/GrsrJ	abnormal coat/hair pigmentation	J:88763
	premature death	J:88763
Atp7aMo-pew3J/Atp7aMo-pew3J C;B6-Atp7aMo-pew3J/GrsrJ	abnormal coat/hair pigmentation	J:88763
	premature death	J:88763
Atp7aMo-pew/Atp7a+ CBA/J-Atp7aMo-pew	abnormal coat/hair pigmentation	J:23989
	irregular coat pigmentation	J:23989
	mottled coat	J:23989
Atp7aMo-pew/Y CBA/J-Atp7aMo-pew	abnormal coat/hair pigmentation	J:23989, J:39098
	diluted coat color	J:23989
	normal mortality/aging	J:23989
	normal reproductive system phenotype	J:23989
Atp7aMo-spot/Atp7a+ Not Specified	variegated coat color	J:69983
Atp7aMo-to/Atp7a+ B6.Cg-Atp7aMo-to/J	abnormal hair shaft morphology	J:79326
	increased intestine copper level	J:79328
	wavy vibrissae	J:79326
Atp7aMo-to/Atp7a+ Not Specified	abnormal hair texture	J:24988
	abnormal limb bone morphology	J:24988
	aortic aneurysm	J:5397
	variegated coat color	J:24988
	wavy vibrissae	J:24988
Atp7aMo-to/Y Not Specified	aortic aneurysm	J:5397
	prenatal lethality	J:24988
Atp7aMo-Tohm/Y B6.Cg-Atp7aMo-Tohm	abnormal visceral yolk sac morphology	J:105797
	abnormal vitelline vascular remodeling	J:105797
	abnormal vitelline vasculature morphology	J:105797
	embryonic lethality during organogenesis, complete penetrance	J:105797
	hemorrhage	J:105797
Atp7aMo-Tohm/Atp7a+ B6.Cg-Atp7aMo-Tohm	abnormal Ammon gyrus morphology	J:105797
	abnormal aorta elastic fiber morphology	J:105797
	abnormal cerebellar granule layer morphology	J:105797
	abnormal cerebral cortex morphology	J:105797
	abnormal motor capabilities/coordination/movement	J:105797
	abnormal Purkinje cell morphology	J:105797
	decreased brain copper level	J:105797
	hemorrhage	J:105797
	increased brain apoptosis	J:105797
	mottled coat	J:105797
	postnatal growth retardation	J:105797
	postnatal lethality, incomplete penetrance	J:105797
Atp7aMo-Tohm/Y involves: AA * C3H/He * C57BL/6 * ICR	abnormal copper level	J:105797
	abnormal visceral yolk sac morphology	J:105797
	embryonic lethality during organogenesis, complete penetrance	J:105797
Atp7aMo-Tohm/Atp7a+ involves: AA * C3H/He * C57BL/6 * ICR	normal mortality/aging	J:105797
	mottled coat	J:105797
Atp7aMo-vbr/Y Not Specified	abnormal aorta elastic fiber morphology	J:5397
	abnormal aorta morphology	J:5397
	abnormal coat/hair pigmentation	J:13473
	abnormal cutaneous collagen fibril morphology	J:5397
	abnormal enzyme/coenzyme activity	J:44695, J:53559
	abnormal mitochondrial physiology	J:44695
	abnormal pH regulation	J:44695
	abnormal skin condition	J:5397
	aortic aneurysm	J:5397
	decreased creatine kinase activity	J:44695
	decreased creatine level	J:44695
	decreased skin tensile strength	J:5397
	normal homeostasis/metabolism phenotype	J:5397
	increased aortic weight	J:5397
	male infertility	J:13473
	postnatal lethality	J:38977
	premature death	J:38977
Atp7aMo-Xm/Y Not Specified	prenatal lethality, complete penetrance	J:38977
Atp7aMo/Y Not Specified	embryonic lethality during organogenesis, complete penetrance	J:249, J:13041
Atp7aMo/Atp7a+ Not Specified	abnormal coat/hair pigmentation	J:249, J:13041
	curly vibrissae	J:249
	decreased litter size	J:13041
	postnatal lethality, incomplete penetrance	J:13041
	prenatal lethality, incomplete penetrance	J:13041
Atp7atm1.1Mjp/Atp7a+ Cldn6tm1(cre)Dkwu/Cldn6+ involves: C57BL/6	curly vibrissae	J:189931
	hypopigmentation	J:189931
	postnatal lethality, incomplete penetrance	J:189931
	prenatal lethality, incomplete penetrance	J:189931
Atp7atm1.1Mjp/Y Cldn6tm1(cre)Dkwu/Cldn6+ involves: C57BL/6	abnormal frontonasal prominence morphology	J:189931
	abnormal tail bud morphology	J:189931
	decreased embryo size	J:189931
	pale yolk sac	J:189931
	pallor	J:189931
	prenatal lethality, complete penetrance	J:189931
Atp7atm1.1Mjp/Y Mnx1tm4(cre)Tmj/Mnx1+ involves: 129S1/Sv * C57BL/6	abnormal copper level	J:221066
	abnormal gait	J:221066
	abnormal gonadal fat pad morphology	J:221066
	abnormal motor capabilities/coordination/movement	J:221066
	abnormal neuromuscular synapse morphology	J:221066
	decreased grip strength	J:221066
	decreased skeletal muscle mass	J:221066
	impaired coordination	J:221066
	limb grasping	J:221066
	motor neuron degeneration	J:221066
	muscular atrophy	J:221066
Atp7atm1.2Mlke/Y involves: C57BL/6J	abnormal cell physiology	J:266704
	abnormal copper level	J:266704
	abnormal skeletal muscle fiber morphology	J:266704
	normal behavior/neurological phenotype	J:266704
	increased brain copper level	J:266704
	increased skeletal muscle fiber diameter	J:266704
	normal nervous system phenotype	J:266704