About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Prkci
protein kinase C, iota
MGI:99260
77 phenotypes from 7 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Prkcitm1.1Rfar/Prkcitm1.1Rfar
involves: 129P2/OlaHsd * BALB/cJ * NMRI
abnormal cell morphology J:202124
abnormal head fold morphology J:202124
abnormal heart tube morphology J:202124
abnormal mesoderm development J:202124
abnormal proximal-distal axis patterning J:202124
abnormal rostral-caudal axis patterning J:202124
absent allantois J:202124
absent heart tube J:202124
absent somites J:202124
embryonic growth retardation J:202124
embryonic lethality during organogenesis, complete penetrance J:202124
small allantois J:202124
small amniotic cavity J:202124
thick embryonic epiblast J:202124
Prkcitm1Hed/Prkcitm1Hed
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cell morphology J:92719
embryonic lethality, complete penetrance J:92719
Prkcitm1Kido/Prkcitm1.1Kido
Tg(Cryaa-cre)10Mlr/?
involves: FVB/N
abnormal anterior eye segment morphology J:154910
abnormal iris morphology J:154910
abnormal iris pigment epithelium J:154910
abnormal lens epithelium morphology J:154910
abnormal lens morphology J:154910
disorganized secondary lens fibers J:154910
microphthalmia J:154910
pupil opacity J:154910
small pupils J:154910
Prkcitm1Kido/Prkcitm1.1Kido
Tg(Nphs1-cre)33Mska/0
involves: C57BL/6 * C57BL/6N * DBA/2
abnormal podocyte morphology J:144995
abnormal podocyte polarity J:144995
abnormal podocyte slit diaphragm morphology J:144995
abnormal podocyte slit junction morphology J:144995
abnormal proximal convoluted tubule morphology J:144995
abnormal renal glomerulus morphology J:144995
decreased podocyte number J:144995
detached podocyte J:144995
dilated glomerular capillary J:144995
expanded mesangial matrix J:144995
fused podocyte foot processes J:144995
glomerulosclerosis J:144995
increased blood urea nitrogen level J:144995
increased circulating creatinine level J:144995
increased urine protein level J:144995
podocyte foot process effacement J:144995
postnatal growth retardation J:144995
premature death J:144995
renal cast J:144995
renal glomerular synechia J:144995
Prkcitm1Kido/Prkcitm1Kido
Tg(Crx-cre)1Tfur/0
Not Specified
abnormal retina morphology J:102364
abnormal retinal photoreceptor morphology J:102364
absent photoreceptor inner segment J:102364
absent photoreceptor outer segment J:102364
hydroencephaly J:102364
microphthalmia J:102364
Prkcitm1Kido/Prkcitm1Kido
Tg(Cryaa-cre)10Mlr/?
involves: FVB/N
abnormal anterior eye segment morphology J:154910
abnormal iris morphology J:154910
abnormal iris pigment epithelium J:154910
abnormal lens epithelium morphology J:154910
abnormal lens morphology J:154910
disorganized secondary lens fibers J:154910
microphthalmia J:154910
pupil opacity J:154910
small pupils J:154910
Prkcitm1Kido/Prkcitm1Kido
Tg(Ins2-cre)25Mgn/0
involves: 129/Sv * C57BL/6 * DBA/2
abnormal pancreas secretion J:95378
decreased circulating glucose level J:95378
impaired glucose tolerance J:95378
Prkcitm1Ltg/Prkcitm1Ltg
involves: 129P2/OlaHsd * NMRI
abnormal head fold morphology J:202124
abnormal heart tube morphology J:202124
abnormal proximal-distal axis patterning J:202124
abnormal rostral-caudal axis patterning J:202124
absent allantois J:202124
absent heart tube J:202124
absent somites J:202124
embryonic growth retardation J:202124
embryonic lethality during organogenesis, complete penetrance J:202124
small allantois J:202124
small amniotic cavity J:202124
thick embryonic epiblast J:202124
Prkcitm1Rfar/Prkci+
Tg(Ckmm-cre)5Khn/?
involves: 129P2/OlaHsd * C57BL/6 * FVB
abnormal circulating lipid level J:123964
abnormal glucose homeostasis J:123964
decreased adipocyte glucose uptake J:123964
decreased cardiac cell glucose uptake J:123964
decreased circulating HDL cholesterol level J:123964
decreased muscle cell glucose uptake J:123964
hepatic steatosis J:123964
impaired glucose tolerance J:123964
increased body weight J:123964
increased circulating cholesterol level J:123964
increased circulating free fatty acid level J:123964
increased circulating glucose level J:123964
increased circulating insulin level J:123964
increased circulating LDL cholesterol level J:123964
increased circulating leptin level J:123964
increased circulating triglyceride level J:123964
increased food intake J:123964
increased susceptibility to autoimmune diabetes J:123964
insulin resistance J:123964
obese J:123964
pancreatic islet hyperplasia J:123964
Prkcitm1Rfar/Prkcitm1Rfar
involves: 129P2/OlaHsd * C57BL/6 * FVB
abnormal circulating lipid level J:123964
abnormal glucose homeostasis J:123964
decreased adipocyte glucose uptake J:123964
decreased cardiac cell glucose uptake J:123964
decreased circulating HDL cholesterol level J:123964
decreased muscle cell glucose uptake J:123964
hepatic steatosis J:123964
impaired glucose tolerance J:123964
increased body weight J:123964
increased circulating cholesterol level J:123964
increased circulating free fatty acid level J:123964
increased circulating glucose level J:123964
increased circulating insulin level J:123964
increased circulating LDL cholesterol level J:123964
increased circulating leptin level J:123964
increased circulating triglyceride level J:123964
insulin resistance J:123964
pancreatic islet hyperplasia J:123964
Prkcitm1Rfar/Prkcitm1Rfar
Tg(NPHS2-cre)295Lbh/0
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal podocyte morphology J:164628
abnormal podocyte slit diaphragm morphology J:164628
abnormal podocyte slit junction morphology J:164628
dilated renal tubules J:164628
glomerulosclerosis J:164628
increased urine protein level J:164628
kidney failure J:164628
podocyte foot process effacement J:164628
postnatal growth retardation J:164628
premature death J:164628
renal cast J:164628
Prkcitm2.1(Prkcz)Ltg/Prkcitm2.1(Prkcz)Ltg
involves: 129P2/OlaHsd * NMRI
embryonic growth retardation J:202124
embryonic lethality during organogenesis, incomplete penetrance J:202124
embryonic lethality, incomplete penetrance J:202124
lethality during fetal growth through weaning, complete penetrance J:202124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory