Xrcc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
MGI:99137

41 phenotypes from 2 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alpl^tm1(cre)Nagy/Alpl⁺ Xrcc1^tm1Pmc/Xrcc1^tm1Pmc involves: 129S1/Sv * 129X1/SvJ	abnormal mitochondrial ATP synthesis coupled electron transport	J:292217
	abnormal mitochondrial morphology	J:292217
	abnormal mitochondrial physiology	J:292217
	abnormal seminiferous tubule epithelium morphology	J:292217
	abnormal seminiferous tubule morphology	J:292217
	abnormal spermatocyte morphology	J:292217
	abnormal spermatogenesis	J:292217
	abnormal spermatogonia morphology	J:292217
	asthenozoospermia	J:292217
	decreased catalase activity	J:292217
	decreased testis weight	J:292217
	increased testis apoptosis	J:292217
	male infertility	J:292217
	oligozoospermia	J:292217
	oxidative stress	J:292217
	small testis	J:292217
Meox2^tm1(cre)Sor/Meox2⁺ Xrcc1^tm1Pmc/Xrcc1^tm1Pmc involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	abnormal embryonic tissue morphology	J:152528
	embryonic lethality during organogenesis, complete penetrance	J:152528
	increased embryonic tissue cell apoptosis	J:152528
Xrcc1^tm1Pmc/Xrcc1^tm1Pmc involves: 129S1/Sv * C57BL/6	no abnormal phenotype detected	J:152528
Xrcc1^tm1Pmc/Xrcc1^tm1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * C57BL/6 * SJL	abnormal brain interneuron morphology	J:152528
	abnormal brain white matter morphology	J:152528
	abnormal DNA repair	J:145730, J:152528
	abnormal neuron differentiation	J:152528
	ataxia	J:152528
	normal cellular phenotype	J:226703
	decreased body size	J:152528
	decreased body weight	J:152528
	decreased brain size	J:152528
	increased neuron apoptosis	J:152528
	loss of GABAergic neurons	J:152528
	postnatal growth retardation	J:152528
	premature death	J:152528
	seizures	J:152528
	small cerebellum	J:152528
Xrcc1^tm1Pmc/Xrcc1^tm1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * FVB/N	abnormal DNA repair	J:170077
Xrcc1^tm1Rpe/Xrcc1^tm1Rpe involves: 129X1/SvJ	abnormal endoderm development	J:54226
	absent mesoderm	J:54226
	decreased embryo size	J:54226
	normal embryo phenotype	J:54226
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:54226
	failure to gastrulate	J:54226

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