About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Xbp1
X-box binding protein 1
MGI:98970
83 phenotypes from 10 alleles in 14 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(tetO-Xbp1_is)#Pesch/0
Tg(Adipoq-rtTA)2Zvw/0
involves: C57BL/6 * C57BL/6N * FVB/N 		abnormal nucleotide metabolism J:260830
abnormal white adipose tissue morphology J:260830
decreased body fat mass J:260830
decreased body temperature J:260830
decreased brown adipose tissue mass J:260830
decreased fat cell size J:260830
decreased susceptibility to diet-induced obesity J:260830
decreased white adipose tissue mass J:260830
increased basal metabolism J:260830
increased carbon dioxide production J:260830
increased fatty acid oxidation J:260830
increased oxygen consumption J:260830
weight loss J:260830
Xbp1tm1.1Geno/Xbp1tm1.1Geno
Tg(Tek-cre)1Ywa/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal blood flow velocity J:211440
abnormal physiological neovascularization J:211440
abnormal response to injury J:211440
abnormal retina blood vessel morphology J:211440
decreased angiogenesis J:211440
Xbp1tm1.2Geno/Xbp1tm1.2Geno
involves: 129S2/SvPas * C57BL/6 		abnormal blood vessel morphology J:211440
decreased cell proliferation J:211440
decreased embryo weight J:211440
embryonic growth retardation J:211440
embryonic lethality during organogenesis, complete penetrance J:211440
pallor J:211440
Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics 		abnormal bone mineralization J:165965
abnormal bone structure J:165965
decreased circulating cholesterol level J:165965
decreased circulating triglyceride level J:165965
decreased IgG1 level J:165965
decreased T cell number J:165965
increased grip strength J:165965
vertebral fusion J:165965
Xbp1tm1b(EUCOMM)Wtsi/Xbp1+
C57BL/6N-Xbp1tm1b(EUCOMM)Wtsi/Ics 		decreased large unstained cell number J:211773
decreased leukocyte cell number J:211773
decreased lymphocyte cell number J:211773
decreased red blood cell distribution width J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular volume J:211773
persistence of hyaloid vascular system J:211773
Xbp1tm1b(EUCOMM)Wtsi/Xbp1tm1b(EUCOMM)Wtsi
C57BL/6N-Xbp1tm1b(EUCOMM)Wtsi/Ics 		preweaning lethality, complete penetrance J:211773
Xbp1tm1Glm/Xbp1tm1Glm
involves: 129S2/SvPas 		abnormal liver development J:59916
anemia J:59916
decreased hepatocyte proliferation J:59916
embryonic growth retardation J:59916
embryonic lethality during organogenesis, complete penetrance J:59916
impaired hematopoiesis J:59916
increased hepatocyte apoptosis J:59916
liver hypoplasia J:59916
pallor J:59916
small liver J:59916
Xbp1tm1Nogu/Xbp1tm1Nogu
involves: 129S/SvEv * A/J 		abnormal heart development J:56678
absent trabeculae carneae J:56678
anoxia J:56678
embryo tissue necrosis J:56678
embryonic growth retardation J:56678
embryonic lethality during organogenesis, complete penetrance J:56678
enlarged pericardium J:56678
myocardium necrosis J:56678
thin ventricular wall J:56678
wavy neural tube J:56678
Xbp1tm1Tiw/Xbp1tm1Tiw
involves: 129S4/SvJae * C57BL/6 		abnormal extraembryonic tissue physiology J:153222
decreased embryo size J:153222
Xbp1tm2Glm/Xbp1+
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL 		small intestinal inflammation J:188627
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Adipoq-rtTA)2Zvw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6N 		abnormal nucleotide metabolism J:260830
increased body fat mass J:260830
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Defa6-icre)1Rsb/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal autophagy J:206084
abnormal Paneth cell morphology J:206084
small intestinal inflammation J:206084
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal lipid homeostasis J:137188
decreased cholesterol level J:137188
decreased circulating triglyceride level J:137188
decreased fatty acids level J:137188
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		normal behavior/neurological phenotype J:131028
decreased susceptibility to prion infection J:131028
normal mortality/aging J:131028
normal nervous system phenotype J:131028
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal autophagy J:206084
abnormal enterocyte physiology J:206084
small intestinal inflammation J:206084
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL 		abnormal cell migration J:188627
abnormal endoplasmic reticulum morphology J:188627
abnormal intestine physiology J:188627
abnormal small intestine goblet cell morphology J:188627
absent Paneth cells J:188627
cachexia J:188627
crypts of Lieberkuhn abscesses J:188627
increased susceptibility to bacterial infection J:188627
increased susceptibility to induced colitis J:188627
intestinal ulcer J:188627
rectal hemorrhage J:188627
small intestinal inflammation J:188627
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal autophagy J:206084
abnormal enterocyte physiology J:206084
small intestinal inflammation J:206084
Xbp1tm3Glm/Xbp1tm3Glm
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal intestine physiology J:188627
decreased Paneth cell number J:188627
decreased small intestinal villus size J:188627
increased apoptosis J:188627
small intestinal inflammation J:188627
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory