62 phenotypes from 12 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Vav1m1Anu/Vav1m1Anu C57BL/6JAnu-Vav1m1Anu	increased T cell number	J:104190
Vav1m1Btlr/Vav1m1Btlr C57BL/6J-Vav1m1Btlr	abnormal humoral immune response	J:265128
	decreased B-1 B cell number	J:265128
	decreased CD4-positive, alpha-beta T cell number	J:265128
	decreased CD8-positive, alpha-beta T cell number	J:265128
	decreased CD8-positive, naive alpha-beta T cell number	J:265128
	decreased IgD level	J:265128
	decreased IgG level	J:265128
	decreased single-positive T cell number	J:265128
	decreased T cell number	J:265128
	increased central memory CD4-positive, alpha-beta T cell number	J:265128
	increased central memory CD8 positive, alpha-beta T cell number	J:265128
	increased effector memory CD4-positive, alpha-beta T cell number	J:265128
	increased IgM level	J:265128
Vav1m2Btlr/Vav1m2Btlr C57BL/6J-Vav1m2Btlr	decreased B-1 B cell number	J:265130
Vav1M3Btlr/Vav1M3Btlr C57BL/6J-Vav1M3Btlr	decreased IgG level	J:272527
	impaired humoral immune response	J:272527
Vav1M4Btlr/Vav1M4Btlr C57BL/6J-Vav1M4Btlr	abnormal CD4-positive T cell differentiation	J:272528
	abnormal CD8-positive, alpha-beta T cell differentiation	J:272528
	abnormal T cell differentiation	J:272528
	decreased B-1 B cell number	J:272528
	decreased CD4-positive, alpha-beta T cell number	J:272528
	decreased CD8-positive, naive alpha-beta T cell number	J:272528
	increased central memory CD4-positive, alpha-beta T cell number	J:272528
	increased central memory CD8 positive, alpha-beta T cell number	J:272528
	increased effector memory CD4-positive, alpha-beta T cell number	J:272528
	increased effector memory CD8-positive, alpha-beta T cell number	J:272528
Vav1M5Btlr/Vav1M5Btlr C57BL/6J-Vav1M5Btlr	decreased CD8-positive, alpha-beta T cell number	J:272529
Vav1tm1Bbd/Vav1+ involves: 129S2/SvPas * C57BL/6J	transmission ratio distortion	J:22517
Vav1tm1Bbd/Vav1tm1Bbd involves: 129S2/SvPas * C57BL/6J	embryonic lethality between implantation and somite formation, complete penetrance	J:22517
	failure of blastocyst to hatch from the zona pellucida	J:22517
Vav1tm1Tyb/Vav1tm1Tyb C.129S2-Vav1tm1Tyb	abnormal negative T cell selection	J:79323
Vav1tm1Tyb/Vav1tm1Tyb either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)	abnormal CD8-positive, alpha-beta T cell physiology	J:190087
	abnormal immune system physiology	J:190087
	abnormal interleukin-2 secretion	J:190087
	abnormal lymphocyte cell number	J:190087
	abnormal T cell number	J:190087
	decreased double-positive T cell number	J:190087
	increased DN2 thymocyte number	J:190087
	increased DN3 thymocyte number	J:190087
	increased double-negative T cell number	J:190087
Vav1tm1Tyb/Vav1tm1Tyb involves: 129S2/SvPas	abnormal double-negative T cell morphology	J:79323
	abnormal T cell physiology	J:79323, J:86654
	decreased double-positive T cell number	J:79323
	decreased interferon-gamma secretion	J:86654
	decreased interleukin-2 secretion	J:86654
	decreased mature B cell number	J:86654
	decreased single-positive T cell number	J:79323
	decreased T cell proliferation	J:86654
	decreased thymocyte number	J:86654
	thymus hypoplasia	J:79323
Vav1tm1Tyb/Vav1tm1Tyb involves: 129S2/SvPas * 129S8/SvEv	abnormal T cell physiology	J:113270
	decreased CD4-positive, alpha-beta T cell number	J:113270
	decreased double-negative T cell number	J:113270
	decreased T cell proliferation	J:113270
Vav1tm1Tyb/Vav1tm1Tyb involves: 129S2/SvPas * C57BL/10 * C57BR/cd	abnormal CD4-positive, alpha beta T cell morphology	J:79323
	abnormal T cell physiology	J:128985
	decreased interleukin-2 secretion	J:128985
	decreased T cell proliferation	J:128985
	decreased tumor necrosis factor secretion	J:128985
Vav1tm1Tyb/Vav1tm1Tyb involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd	abnormal CD4-positive, alpha beta T cell morphology	J:113270
	abnormal negative T cell selection	J:113270
Vav1tm2Bbd/Vav1tm2Bbd B6.129-Vav1tm2Bbd	abnormal CD4-positive T cell differentiation	J:141390
	abnormal positive T cell selection	J:141390
	abnormal T cell physiology	J:141390
	decreased double-positive T cell number	J:141390
	decreased interleukin-4 secretion	J:71161
	decreased NK T cell number	J:71161
	decreased T cell number	J:141390
	normal immune system phenotype	J:71161
	impaired natural killer cell mediated cytotoxicity	J:71161
Vav1tm2Bbd/Vav1tm2Bbd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal B cell number	J:55647
	abnormal lymph node cell ratio	J:69806
	abnormal response to infection	J:55647
	abnormal splenic cell ratio	J:69806
	abnormal T cell differentiation	J:47596
	abnormal T cell number	J:47596
	decreased B cell proliferation	J:55647, J:69806
	decreased B-1 B cell number	J:55647
	decreased CD4-positive, alpha-beta T cell number	J:47596
	decreased CD8-positive, alpha-beta T cell number	J:47596
	decreased IgG1 level	J:55647
	decreased IgG2a level	J:55647
	decreased IgG3 level	J:69806
	decreased IgG level	J:55647
	increased double-negative T cell number	J:47596
	increased transitional stage B cell number	J:69806
Vav1tm2Bbd/Vav1tm2Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal T cell activation	J:47596
	abnormal T cell differentiation	J:47596
	decreased B-1 B cell number	J:47596
	decreased CD4-positive, alpha-beta T cell number	J:47596
	decreased CD8-positive, alpha-beta T cell number	J:47596
	decreased interleukin-2 secretion	J:47596
	decreased T cell proliferation	J:47596
	normal immune system phenotype	J:47596
	thymus hypoplasia	J:47596
Vav1tm2Tyb/Vav1tm2Tyb involves: 129S4/SvJae * 129S8/SvEv	abnormal T cell physiology	J:113270
	decreased CD4-positive, alpha-beta T cell number	J:113270
	decreased double-negative T cell number	J:113270
	decreased T cell proliferation	J:113270
Vav1tm2Tyb/Vav1tm2Tyb involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd	abnormal CD4-positive, alpha beta T cell morphology	J:113270
	abnormal negative T cell selection	J:113270
Vav1tm3Tyb/Vav1tm3Tyb involves: 129S4/SvJae * 129S8/SvEv	no abnormal phenotype detected	J:113270
Vav1tm4Tyb/Vav1tm4Tyb either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)	abnormal CD4-positive, alpha-beta T cell physiology	J:190087
	abnormal CD8-positive, alpha-beta T cell physiology	J:190087
	abnormal immune serum protein physiology	J:190087
	abnormal immune system physiology	J:190087
	abnormal interleukin-2 secretion	J:190087
	abnormal lymphocyte cell number	J:190087
	abnormal T cell number	J:190087
	abnormal T cell physiology	J:190087
	increased circulating interferon-gamma level	J:190087
	increased DN2 thymocyte number	J:190087
	increased DN3 thymocyte number	J:190087