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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tyrp1
tyrosinase-related protein 1
MGI:98881
36 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
a/a
Lystbg/Lystbg
Tyrp1b/Tyrp1b
involves: C3H/Rl * C57BL/6J
abnormal choroid melanin granule morphology J:5346
abnormal retinal melanin granule morphology J:5346
a/a
Mlphln/Mlphln
Tyrp1b/Tyrp1b
C57L/J
abnormal coat/hair pigmentation J:5095
abnormal melanocyte morphology J:5095
diluted coat color J:5095
a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+
involves: C58 * CT/Ch
diluted coat color J:13094
a/a
Tyrp1B-lt/Tyrp1+
Not Specified
abnormal dorsoventral coat patterning J:13094
abnormal hair shaft melanin granule distribution J:13094
abnormal hair shaft melanin granule morphology J:13094
reduced hair shaft melanin granule number J:13094
a/a
Tyrp1B-lt/Tyrp1B-lt
Not Specified
abnormal dorsoventral coat patterning J:13094
abnormal hair follicle melanin granule morphology J:13094
abnormal hair shaft melanin granule distribution J:13094
abnormal hair shaft melanin granule morphology J:13094
enlarged hair follicle melanin granules J:13094
reduced hair shaft melanin granule number J:13094
A/a
Tyrp1B-lt/Tyrp1B-lt
Not Specified
diluted coat color J:13094
a/a
Tyrp1b/Tyrp1b
involves: C57BL/6J
abnormal melanosome morphology J:5346
a/a
Tyrp1b/Tyrp1b
Not Specified
abnormal coat/hair pigmentation J:12970
abnormal eye pigmentation J:12970
abnormal melanocyte morphology J:12970
a/a
Tyrp1b/Tyrp1b
wad/wad+
Not Specified
diluted coat color J:162146
a/a
Tyrp1b/Tyrp1b
wad/wad
Not Specified
diluted coat color J:162146
A/?
Lystbg/Lystbg
Tyrp1b/Tyrp1b
Not Specified
decreased eye pigmentation J:29744
diluted coat color J:29744
Ay/a
Tyrp1B-lt/?
Not Specified
yellow coat color J:13094
Cdk5rap2an/Cdk5rap2an
Tyrp1B-lt/Tyrp1B-lt
WBB6F1
abnormal mitosis J:7537
abnormal parturition J:753
aneuploidy J:7537
forebrain hypoplasia J:160533
impaired hematopoiesis J:7003
increased histiocytic sarcoma incidence J:102334
microcephaly J:160533
GpnmbR150X/GpnmbR150X
Tyrc-2J/Tyrc-2J
Tyrp1b/Tyrp1b
B6.Cg-Tyrp1b GpnmbR150X Tyrc-2J
normal vision/eye phenotype J:128215
GpnmbR150X/GpnmbR150X
Tyrp1b/Tyrp1b
B6.D2-Tyrp1b GpnmbR150X
abnormal intraocular pressure J:128215
abnormal iris morphology J:128215
abnormal iris pigmentation J:128215
iris atrophy J:128215
GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa
DBA/2J
abnormal iris pigment epithelium J:54013
abnormal iris stroma morphology J:54013
optic nerve atrophy J:54013
retinal ganglion cell degeneration J:54013
GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa
involves: C57BL/6J * DBA/2J
abnormal iris pigment epithelium J:54013
abnormal iris stroma morphology J:54013
optic nerve atrophy J:54013
retinal ganglion cell degeneration J:54013
Lystbg-slt/Lystbg-slt
Myo5ad/Myo5ad
Oca2p/Oca2p
Tyrp1b/Tyrp1b
involves: CT/Ch * YZ57/Ch
abnormal hair cycle J:83269
delayed hair regrowth J:83269
diluted coat color J:83269
premature hair loss J:83269
Rag1tm1Mom/Rag1tm1Mom
Tyrp1B-w/Tyrp1B-w
X/Tg(Tcra,Tcrb)9Rest
involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6
altered tumor susceptibility J:138466
Rgsc58/Rgsc58+
Tyrp1b/Tyrp1b
involves: C57BL/6JJcl * DBA/2JJcl
white spotting J:133634

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory