119 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
a/a Lystbg/Lystbg Tyrc/Tyrc involves: C3H/Rl * C57BL/6J	abnormal choroid melanin granule morphology	J:5346
	abnormal melanogenesis	J:5346
	abnormal melanosome morphology	J:5346
	abnormal retina melanin granule morphology	J:5346
A/A Tyrc-ch/Tyrc-ch Not Specified	abnormal coat appearance	J:36414
	abnormal coat/hair pigmentation	J:36414
	abnormal hair follicle pheomelanosome pheomelanin content	J:36414
a/a Tyrc-i/Tyrc-i involves: STOCK Tyrc-r	abnormal coat/hair pigmentation	J:83666
	diluted coat color	J:83666
a/a Tyrc/Tyrc involves: C57BL/6J	abnormal melanogenesis	J:5346
a/a Tyrc/Tyrem2Ove involves: C57BL/6 * FVB	decreased eye pigmentation	J:94077
	diluted coat color	J:94077
a/a Tyrc/Tyrem4Ove involves: C57BL/6 * FVB	abnormal eye pigmentation	J:94077
	diluted coat color	J:94077
a/a Tyrc/Tyrem9Ove involves: C57BL/6 * FVB	diluted coat color	J:94077
a/a Tyrc/Tyrem14Ove involves: C57BL/6 * FVB	diluted coat color	J:94077
a/a Tyrem2Ove/Tyrem2Ove involves: C57BL/6 * FVB	abnormal eye pigmentation	J:94077
	abnormal tail pigmentation	J:94077
	diluted coat color	J:94077
a/a Tyrem4Ove/Tyrem4Ove involves: C57BL/6 * FVB	abnormal eye pigmentation	J:94077
	decreased tail pigmentation	J:94077
	diluted coat color	J:94077
a/a Tyrem14Ove/Tyrem14Ove involves: C57BL/6 * FVB	diluted coat color	J:94077
A/a Tyrem15Ove/Tyrem15Ove involves: C57BL/6 * FVB	decreased tail pigmentation	J:94077
	diluted coat color	J:94077
A/? Tyrc/Tyrem1Ove involves: C57BL/6 * FVB	decreased eye pigmentation	J:94077
	diluted coat color	J:94077
A/? Tyrc/Tyrem6Ove involves: C57BL/6 * FVB	diluted coat color	J:94077
	variegated eye pigmentation pattern	J:94077
A/? Tyrc/Tyrem7Ove involves: C57BL/6 * FVB	diluted coat color	J:94077
A/? Tyrc/Tyrem12Ove involves: C57BL/6 * FVB	diluted coat color	J:94077
A/? Tyrc/Tyrem13Ove involves: C57BL/6 * FVB	normal pigmentation phenotype	J:94077
A/? Tyrem1Ove/Tyrem1Ove involves: C57BL/6 * FVB	diluted coat color	J:94077
A/? Tyrem7Ove/Tyrem7Ove involves: C57BL/6 * FVB	abnormal eye pigmentation	J:94077
	diluted coat color	J:94077
A/? Tyrem8Ove/Tyrem8Ove involves: C57BL/6 * FVB	decreased ear pigmentation	J:94077
	decreased tail pigmentation	J:94077
	diluted coat color	J:94077
	variegated eye pigmentation pattern	J:94077
A/? Tyrem9Ove/Tyrem9Ove involves: C57BL/6 * FVB	decreased eye pigmentation	J:94077
	diluted coat color	J:94077
A/? Tyrem12Ove/Tyrem12Ove involves: C57BL/6 * FVB	decreased eye pigmentation	J:94077
	diluted coat color	J:94077
A/? Tyrem13Ove/Tyrem13Ove involves: C57BL/6 * FVB	normal pigmentation phenotype	J:94077
Atm1.1Arte/Atm1.1Arte Tyrtm1Arte/Tyrtm1Arte C57BL/6NTac-Atm1.1Arte Tyrtm1Arte	absent coat pigmentation	J:213411
	absent eye pigmentation	J:213411
Arb2aTg(Tyr)TpNpin/Arb2a+ involves: FVB/N	head spot	J:260599
Arb2aTg(Tyr)TpNpin/Arb2aTg(Tyr)TpNpin involves: FVB/N	abnormal cranial nerve morphology	J:260599
	abnormal craniofacial morphology	J:260599
	abnormal facial nerve morphology	J:260599
	abnormal heart morphology	J:260599
	abnormal neural crest cell migration	J:260599
	abnormal oropharynx morphology	J:260599
	abnormal outer ear morphology	J:260599
	abnormal semicircular canal morphology	J:260599
	abnormal seminiferous tubule morphology	J:329885
	abnormal uterine horn morphology	J:260599
	absent coat pigmentation	J:260599
	blepharoptosis	J:260599
	circling	J:260599
	cleft palate	J:260599
	cryptorchism	J:260599
	decreased cell proliferation	J:260599
	decreased neural crest cell proliferation	J:260599
	delayed fontanelle closure	J:260599
	delayed vaginal opening	J:260599
	normal digestive/alimentary phenotype	J:260599
	exencephaly	J:260599
	facial asymmetry	J:260599
	heart left ventricle hypertrophy	J:260599
	hydrocephaly	J:260599
	impaired olfaction	J:260599
	increased heart weight	J:260599
	increased neural crest cell apoptosis	J:260599
	olfactory bulb hypoplasia	J:260599
	postnatal growth retardation	J:260599
	postnatal lethality, incomplete penetrance	J:260599
	reduced fertility	J:260599
	renal hypoplasia	J:260599
	retina coloboma	J:260599
	sex reversal	J:260599
	small penis	J:260599
	small seminal vesicle	J:260599
	thymus hypoplasia	J:260599
Arb2aTg(Tyr)TpNpin/Arb2aTg(Tyr)TpNpin Gata4tm1(cre)Svs/Gata4+ involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal neural crest cell migration	J:260599
Chd7Gt(S20-7E1)Sor/Chd7+ Arb2aTg(Tyr)TpNpin/Arb2a+ involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	abnormal optic fissure closure	J:260599
	circling	J:260599
	decreased body size	J:260599
	postnatal lethality, incomplete penetrance	J:260599
	prenatal lethality, incomplete penetrance	J:260599
	retina coloboma	J:260599
	sex reversal	J:260599
Cyp1b1tm1Gonz/Cyp1b1tm1Gonz Tyrc-2J/Tyrc-2J B6.Cg-Tyrc-2J Cyp1b1tm1Gonz	abnormal iridocorneal angle	J:82280
	abnormal trabecular meshwork morphology	J:82280
	absent Schlemm's canal	J:82280
	anterior iris synechia	J:82280
Dp(11Cops3-Rnf112)1Jrl/0 Tyrc-Brd/Tyrc-Brd B6Brd.Cg-Tyrc-Brd Dp(11Cops3-Rnf112)1Jrl	abnormal contextual conditioning behavior	J:114996
	abnormal nest building behavior	J:138598
	abnormal social investigation	J:138598
	abnormal social/conspecific interaction behavior	J:138598
	decreased abdominal fat pad weight	J:138598
	decreased body weight	J:138598
	decreased brain weight	J:138598
	decreased exploration in new environment	J:114996
	decreased vertical activity	J:114996
	decreased vocalization	J:138598
	hyperactivity	J:114996
	increased anxiety-related response	J:138598
Foxc1tm1Blh/Foxc1+ Tyrc-2J/Tyrc-2J B6.Cg-Tyrc-2J Foxc1tm1Blh	abnormal aqueous drainage system morphology	J:82280
	abnormal trabecular meshwork morphology	J:82280
	absent Schlemm's canal	J:82280
	iris synechia	J:82280
GpnmbR150X/GpnmbR150X Tyrc-2J/Tyrc-2J Tyrp1b/Tyrp1b B6.Cg-Tyrp1b GpnmbR150X Tyrc-2J	normal vision/eye phenotype	J:128215
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu Trp53tm1Thl/Trp53tm1Thl Tyrc-Brd/Tyrc-Brd involves: 129/Sv * 129S4/SvJae * C57BL/6	increased glioblastoma incidence	J:172585
	increased tumor growth/size	J:172585
	premature death	J:172585
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu Tyrc-Brd/Tyrc-Brd involves: 129/Sv * 129S4/SvJae * C57BL/6	increased glioblastoma incidence	J:172585
	premature death	J:172585
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+ Tyrc-Brd/Tyrc-Brd involves: 129/Sv * C57BL/6	normal mortality/aging	J:172585
	normal neoplasm	J:172585
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien Tg(Itgax-cre)1-1Reiz/0 Tyrc-2J/Tyrc-2J involves: C57BL/6 * CBA	normal immune system phenotype	J:172226
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien Tyrc-2J/Tyrc-2J involves: C57BL/6	normal immune system phenotype	J:172226
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien Tyrc-2J/Tyrc-2J Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6	decreased circulating interferon-alpha level	J:172226
	decreased circulating interferon-beta level	J:172226
	decreased susceptibility to bacterial infection	J:172226
In(11Trp53;11Wnt3)8Brd/+ Tyrc-Brd/Tyrc-Brd involves: 129S7/SvEvBrd * C57BL/6Brd	normal pigmentation phenotype	J:56548
Lgi1tm1.1Jkc/Lgi1+ Tyrc-Brd/Tyrc-Brd B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc	abnormal eye pigmentation	J:158715
	absent coat pigmentation	J:158715
Lgi1tm1.1Jkc/Lgi1tm1.1Jkc Tyrc-Brd/Tyrc-Brd B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc	abnormal coat/hair pigmentation	J:158715
	abnormal eye pigmentation	J:158715
	clonic seizures	J:158715
	decreased body size	J:158715
	enhanced AMPA-mediated synaptic currents	J:158715
	enhanced NMDA-mediated synaptic currents	J:158715
	increased miniature excitatory postsynaptic current frequency	J:158715
	normal nervous system phenotype	J:158715
	postnatal lethality, complete penetrance	J:158715
	seizures	J:158715
Ltftm1(icre)Tdku/Ltftm1(icre)Tdku Tyrc-2J/Tyrc-2J involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:211105
Mecp2em1Dkatz/Mecp2+ Tyrc-ch/Tyrc-ch FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J	abnormal locomotor behavior	J:101977
	normal reproductive system phenotype	J:101977
Mecp2em1Dkatz/Mecp2em1Dkatz Tyrc-ch/Tyrc-ch FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J	female infertility	J:101977
Mecp2em1Dkatz/Y Tyrc-ch/Tyrc-ch FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J	premature death	J:101977
Mesdtm2.1Bch/Tyrc-3YPSd involves: 101/Rl * C3H/Rl * C57BL/6 * C57BL/6J	absent mesoderm	J:209024
	failure to gastrulate	J:209024
	small embryonic epiblast	J:209024
Mlanatm1.2Bee/Mlanatm1.2Bee Tyrc/Tyrc involves: 129S/SvEv * C57BL/6 * FVB/N * SJL	abnormal hair follicle melanocyte morphology	J:194886
	absent skin pigmentation	J:194886
Oca2p/Oca2p Tyrc-i/Tyrc-i involves: STOCK Tyrc-r	abnormal coat/hair pigmentation	J:83666
Plin2tm1Itl/Plin2tm1Itl Rpe65tm1Tmr/Rpe65tm1Tmr Tyrc-2J/Tyrc-2J involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6	abnormal vitamin A metabolism	J:142021
Tdo2chky/Tdo2chky Tyrc/Tyrc STOCK Tdo2chky/J	abnormal lens morphology	J:149273
	cataract	J:149273
	yellow coat color	J:149273
Tenm4l7Rn3-4R/Tyrc-26DVT involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock	abnormal cervical axis morphology	J:96673
	abnormal limb bud morphology	J:96673
	abnormal vasculogenesis	J:96673
	decreased body size	J:96673
	embryonic growth retardation	J:96673
	kinked neural tube	J:96673
	lumbar vertebral fusion	J:96673
	normal mortality/aging	J:96673
	prenatal lethality, complete penetrance	J:96673
	thoracic vertebral fusion	J:96673
Thtm1Srt/Thtm1Srt Tyrc/Tyrc involves: 129S2/SvPas * C57BL/6J * ICR	abnormal adrenaline level	J:54692
	abnormal noradrenaline level	J:54692
	decreased dopamine level	J:54692
	prenatal lethality, complete penetrance	J:54692
Tyrc-2CHLb/Tyrc-2CHLb involves: 101/Rl * C3H/Rl	prenatal lethality, complete penetrance	J:10322, J:100221
Tyrc-2CHLb/Tyrc-202G involves: 101/Rl * C3H/Rl	prenatal lethality, complete penetrance	J:100221
Tyrc-2CHLb/Tyrc involves: 101/Rl * C3H/Rl	absent coat pigmentation	J:100221
Tyrc-26DVT/Tyr+ involves: 101/Rl * C3H/Rl * T-stock	no abnormal phenotype detected	J:100221
Tyrc-26DVT/Tyrc-26DVT involves: 101/Rl * C3H/Rl * T-stock	embryonic lethality before implantation, complete penetrance	J:23420, J:100221, J:141526
Tyrc-ch/Del(7)Tyrc-3H involves: 101/H * C3H/HeH	abnormal coat/hair pigmentation	J:5063
	diluted coat color	J:5063
Tyrc-ch/Del(7)Tyrc-6H involves: 101/H * C3H/HeH	abnormal coat/hair pigmentation	J:5741
	diluted coat color	J:5741
Tyrc/Del(7)Tyrc-3H involves: 101/H * C3H/HeH	absent coat pigmentation	J:5063
Tyrc/Tyrc-26DVT involves: 101/Rl * C3H/Rl * T-stock	absent coat pigmentation	J:100221
War/War Tyrc-e/Tyrc-e PBI	abnormal physiological response to xenobiotic	J:5635
	decreased physiological sensitivity to xenobiotic	J:5635