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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Twist1
twist basic helix-loop-helix transcription factor 1
MGI:98872
35 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(CAG-cat,-Twist1)1Dbsp/0
Tg(Col2a1-cre)1Bhr/0
involves: C57BL/6 * FVB * SJL
abnormal long bone epiphyseal plate morphology J:178268
abnormal long bone epiphyseal plate proliferative zone J:178268
abnormal ossification involved in bone maturation J:178268
decreased body size J:178268
decreased body weight J:178268
decreased bone trabecula number J:178268
decreased trabecular bone thickness J:178268
decreased trabecular bone volume J:178268
increased width of hypertrophic chondrocyte zone J:178268
short limbs J:178268
Twist1Pas/Twist1+
involves: C57BL/6 * PDT/Pas
cleft palate J:86815
polydactyly J:86815
Twist1Pas/Twist1Pas
involves: C57BL/6 * PDT/Pas
exencephaly J:86815
prenatal lethality, incomplete penetrance J:86815
Twist1Pde/Twist1+
involves: 129S1/Sv * C57BL/6J
polydactyly J:69450
Twist1Pde/Twist1Pde
involves: 129S1/Sv * C57BL/6J
embryonic lethality, complete penetrance J:69450
exencephaly J:69450
open neural tube J:69450
Twist1Ska10/Twist1+
C57BL/6J-Twist1Ska10
polydactyly J:90056
premature cranial suture closure J:90056
Twist1Ska10/Twist1+
involves: C57BL/6J
abnormal gait J:89098
abnormal limb bone morphology J:89098
decreased body size J:89098
polydactyly J:89098
Twist1Ska10/Twist1Ska10
C57BL/6J-Twist1Ska10
abnormal bone ossification J:90056
abnormal clavicle morphology J:90056
abnormal osteoblast differentiation J:90056
abnormal rib morphology J:90056
neonatal lethality, complete penetrance J:90056
normal nervous system phenotype J:90056
polydactyly J:90056
premature endochondral bone ossification J:90056
short limbs J:90056
Twist1tm1Bhr/Twist1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal limb morphology J:79294
abnormal temporal bone morphology J:79294
normal craniofacial phenotype J:79294
premature cranial suture closure J:79294
Twist1tm1Bhr/Twist1+
involves: 129S7/SvEvBrd
premature cranial suture closure J:108218
Twist1tm1Bhr/Twist1+
involves: 129S7/SvEvBrd * C57BL/6
enlarged interparietal bone J:44379
polydactyly J:44379
Twist1tm1Bhr/Twist1+
involves: 129S7/SvEvBrd * C57BL/6J
polydactyly J:128714
short squamosal bone J:128714
Twist1tm1Bhr/Twist1+
involves: 129S/Sv * 129X1/SvJ * C57BL/6
abnormal osteoblast differentiation J:90056
premature cranial suture closure J:90056
Twist1tm1Bhr/Twist1tm1Bhr
involves: 129S7/SvEvBrd
abnormal muscle development J:124278
Twist1tm1Bhr/Twist1tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6
embryonic lethality, complete penetrance J:24349
exencephaly J:24349
open neural tube J:24349
Twist1tm1Bhr/Twist1tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6J
abnormal forelimb morphology J:128714
exencephaly J:128714
internal hemorrhage J:128714
Twist1tm1Bhr/Twist1tm2.1Bhr
involves: 129S7/SvEvBrd * C57BL/6J
abnormal forelimb morphology J:128714
exencephaly J:128714
internal hemorrhage J:128714
Twist1tm1Bhr/Twist1tm2Bhr
involves: 129S7/SvEvBrd * C57BL/6J
polydactyly J:128714
short squamosal bone J:128714
Twist1tm2Bhr/Twist1tm2Bhr
involves: 129S7/SvEvBrd * C57BL/6J
normal skeleton phenotype J:128714

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory