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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Thrb
thyroid hormone receptor beta
MGI:98743
112 phenotypes from 13 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss 		normal hearing/vestibular/ear phenotype J:124153
Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss 		abnormal pituitary gland physiology J:65885
abnormal thyroid follicle morphology J:65885
enlarged thyroid gland J:65885
increased circulating thyroid-stimulating hormone level J:65885
increased circulating thyroxine level J:65885
increased circulating triiodothyronine level J:65885
short femur J:65885
short tibia J:65885
Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal habituation J:114325
impaired learning J:114325
Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J 		increased thyroid carcinoma incidence J:92629
increased thyroid gland weight J:92629
premature death J:92629
Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac 		increased cardiac muscle cell glucose uptake J:95397
Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		abnormal pituitary hormone level J:95391
abnormal thyroid hormone level J:95391
enlarged pituitary gland J:95391
increased circulating thyroid-stimulating hormone level J:95391
increased circulating thyroxine level J:95391
increased circulating triiodothyronine level J:95391
increased pituitary adenoma incidence J:95391
Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss 		abnormal cochlea morphology J:124153
abnormal organ of Corti morphology J:124153
abnormal tectorial membrane morphology J:124153
cochlear hair cell degeneration J:124153
detached tectorial membrane J:124153
enlarged tectorial membrane J:124153
impaired hearing J:124153
increased or absent threshold for auditory brainstem response J:124153
organ of Corti degeneration J:124153
premature cranial suture closure J:103351
premature endochondral bone ossification J:103351
premature intramembranous bone ossification J:103351
short tibia J:103351
Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss 		abnormal bone mineralization J:84310
abnormal circulating hormone level J:65885
abnormal cranium morphology J:84310
abnormal epiphyseal plate morphology J:84310
abnormal fetal growth/weight/body size J:84310
abnormal limb morphology J:84310
abnormal long bone epiphyseal plate proliferative zone J:84310
abnormal long bone hypertrophic chondrocyte zone J:84310
abnormal pituitary gland physiology J:65885
abnormal skeleton development J:84310
decreased body length J:84310
decreased body size J:65885, J:84310
enlarged thyroid gland J:65885
increased circulating thyroid-stimulating hormone level J:65885
increased circulating thyroxine level J:65885, J:84310
increased circulating triiodothyronine level J:65885
increased thyrotroph cell number J:65885
postnatal growth retardation J:65885, J:84310
premature cranial suture closure J:84310
premature endochondral bone ossification J:84310
premature intramembranous bone ossification J:84310
short femur J:65885
short tibia J:65885
small fontanelles J:84310
thyroid gland hyperplasia J:65885
Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal habituation J:114325
decreased vertical activity J:114325
hyperactivity J:114325
impaired learning J:114325
Thrbtm1Df/Thrb+
either: B6.129S1-Thrbtm1Df or (involves: 129S1/Sv * C57BL/6J) 		normal behavior/neurological phenotype J:103702
Thrbtm1Df/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J 		enlarged thyroid gland J:92629
increased thyroid carcinoma incidence J:92629
premature death J:92629
respiratory distress J:92629
Thrbtm1Df/Thrbtm1Df
B6J.129S1-Thrbtm1Df 		abnormal cochlear inner hair cell physiology J:118402
abnormal response/metabolism to endogenous compounds J:222168
increased or absent threshold for auditory brainstem response J:118402
Thrbtm1Df/Thrbtm1Df
either: B6.129S1-Thrbtm1Df or (involves: 129S1/Sv * C57BL/6J) 		audiogenic seizures J:103702
deafness J:103702
increased circulating thyroxine level J:103702
increased circulating triiodothyronine level J:103702
increased or absent threshold for auditory brainstem response J:103702
increased thyroid-stimulating hormone level J:103702
Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J 		abnormal cochlear inner hair cell physiology J:48666, J:73382, J:118178
abnormal cochlear outer hair cell physiology J:73382
abnormal organ of Corti morphology J:73382
abnormal tectorial membrane striated-sheet matrix morphology J:73382
abnormal thyroid follicle morphology J:34421
normal behavior/neurological phenotype J:34421, J:63101
deafness J:63101
decreased circulating thyroxine level J:34421
decreased cochlear outer hair cell electromotility J:73382, J:118178
delayed inner ear development J:63101, J:73382
enlarged tectorial membrane J:73382
enlarged thyroid gland J:34421
increased activity of thyroid gland J:34421
increased circulating thyroxine level J:34421
increased circulating triiodothyronine level J:34421
increased or absent threshold for auditory brainstem response J:63101, J:118178
increased thyroid-stimulating hormone level J:34421
short cochlear outer hair cells J:118178
thyroid gland hyperplasia J:34421
Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J * FVB/NJ 		abnormal cochlear nerve compound action potential J:145941
decreased cochlear microphonics J:145941
enlarged tectorial membrane J:145941
increased or absent distortion product otoacoustic emission threshold J:145941
increased or absent threshold for auditory brainstem response J:145941
Thrbtm1Df/Thrbtm1Mkni
Tg(Pres-cre)1Jnz/0
involves: 129S1/Sv * C57BL/6J * FVB/NJ 		abnormal cochlear inner hair cell physiology J:145941
increased or absent threshold for auditory brainstem response J:145941
Thrbtm1Ehs/Thrbtm1Ehs
C57BL/6-Thrbtm1Ehs 		decreased excitatory postsynaptic current amplitude J:217014
normal homeostasis/metabolism phenotype J:217014
impaired synaptic plasticity J:217014
reduced long-term potentiation J:217014
Thrbtm1Few/Thrbtm1Few
involves: 129S4/SvJae 		abnormal thyroid gland physiology J:56668
normal hearing/vestibular/ear phenotype J:56668
increased circulating thyroid-stimulating hormone level J:56668
increased thyroxine level J:56668
increased triiodothyronine level J:56668
Thrbtm1Mkni/Thrb+
Hprt1tm1(TG-cre)1Sasr/Y
involves: 129/Sv * C57BL/6 		decreased thyroid gland weight J:208718
Thrbtm1Mkni/Thrbtm1Mkni
Hprt1tm1(TG-cre)1Sasr/Y
involves: 129/Sv * C57BL/6 		abnormal thyroid hormone level J:208718
decreased circulating thyroid-stimulating hormone level J:208718
decreased thyroid gland weight J:208718
normal growth/size/body region phenotype J:208718
increased circulating levels of thyroid hormone J:208718
increased circulating thyroxine level J:208718
increased thyroxine level J:208718
Thrbtm1Olc/Thrbtm1Olc
involves: 129 		abnormal bone mineralization J:120899
abnormal bone structure J:120899
abnormal chondrocyte physiology J:114970
abnormal long bone epiphyseal plate morphology J:120899
abnormal osteoclast physiology J:120899
abnormal response/metabolism to endogenous compounds J:120899, J:126521
abnormal thyroid follicle morphology J:52829
abnormal trabecular bone morphology J:120899
normal cardiovascular system phenotype J:68577
decreased body weight J:120899
decreased circulating insulin-like growth factor I level J:120899
decreased compact bone thickness J:120899
decreased long bone epiphyseal plate size J:120899
decreased trabecular bone thickness J:120899
normal digestive/alimentary phenotype J:52829
increased activity of thyroid gland J:120899
increased circulating thyroid-stimulating hormone level J:52829, J:120899, J:126521
increased circulating thyroxine level J:52829, J:68577, J:120899, J:126521
increased circulating triiodothyronine level J:52829, J:126521
increased compact bone thickness J:120899
increased heart rate J:68577
increased osteoclast cell number J:120899
osteoporosis J:120899
premature endochondral bone ossification J:120899
short limbs J:120899
short tail J:120899
short tibia J:120899
small fontanelles J:120899
thyroid gland hyperplasia J:52829
Thrbtm2a(EUCOMM)Wtsi/Thrbtm2a(EUCOMM)Wtsi
C57BL/6N-Thrbtm2a(EUCOMM)Wtsi/H 		decreased circulating glycerol level J:165965
decreased hemoglobin content J:165965
tremors J:165965
Thrbtm2Df/Thrbtm2Df
involves: 129S1/Sv * C57BL/6J 		abnormal cone electrophysiology J:66737
abnormal retina cone cell morphology J:66737
normal hearing/vestibular/ear phenotype J:66737
increased circulating thyroid-stimulating hormone level J:66737
increased circulating triiodothyronine level J:66737
Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6 		abnormal cerebellar Purkinje cell layer J:77623
abnormal Purkinje cell morphology J:77623
abnormal spatial learning J:77623
decreased Purkinje cell number J:77623
increased circulating thyroid-stimulating hormone level J:77623
increased thyroxine level J:77623
increased triiodothyronine level J:77623
small cerebellum J:77623
thin cerebellar molecular layer J:77623
Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6 		abnormal cerebellar Purkinje cell layer J:77623
abnormal Purkinje cell morphology J:77623
abnormal spatial learning J:77623
decreased Purkinje cell number J:77623
increased circulating thyroid-stimulating hormone level J:77623
increased thyroxine level J:77623
increased triiodothyronine level J:77623
small cerebellum J:77623
thin cerebellar molecular layer J:77623
Thrbtm3.1Df/Thrbtm3.1Df
B6J.Cg-Thrbtm3.1Df 		abnormal response/metabolism to endogenous compounds J:222168
Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6 		abnormal cochlea morphology J:85158
abnormal pillar cell morphology J:85158
abnormal pituitary gland physiology J:85158
abnormal retina cone cell morphology J:85158
cochlear outer hair cell degeneration J:85158
enlarged tectorial membrane J:85158
enlarged thyroid gland J:85158
increased activity of thyroid gland J:85158
increased circulating thyroid-stimulating hormone level J:85158
increased circulating thyroxine level J:85158
increased circulating triiodothyronine level J:85158
increased or absent distortion product otoacoustic emission threshold J:85158
increased or absent threshold for auditory brainstem response J:85158
increased thyrotroph cell number J:85158
sensorineural hearing loss J:85158
Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6 		abnormal cochlea morphology J:85158
abnormal pillar cell morphology J:85158
abnormal pituitary gland physiology J:85158
abnormal retina cone cell morphology J:85158
abnormal tectorial membrane morphology J:85158
absent distortion product otoacoustic emissions J:85158
decreased cochlear outer hair cell number J:85158
degeneration of organ of Corti supporting cells J:85158
enlarged tectorial membrane J:85158
enlarged thyroid gland J:85158
increased circulating thyroid-stimulating hormone level J:85158
increased or absent distortion product otoacoustic emission threshold J:85158
increased or absent threshold for auditory brainstem response J:85158
increased thyrotroph cell number J:85158
sensorineural hearing loss J:85158
spiral ligament degeneration J:85158
Thrbtm6.1Few/Thrb+
involves: 129 * C57BL/6 		decreased body weight J:150008
normal homeostasis/metabolism phenotype J:150008
increased circulating thyroxine level J:150008
increased circulating triiodothyronine level J:150008
Thrbtm6.1Few/Thrbtm6.1Few
involves: 129 * C57BL/6 		decreased body weight J:150008
normal homeostasis/metabolism phenotype J:150008
increased circulating thyroxine level J:150008
increased circulating triiodothyronine level J:150008
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory