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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tcrb
T cell receptor beta chain
MGI:98578
276 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * DBA/2
increased T cell proliferation J:209886
Airetm1.1Doi/Airetm1.1Doi
Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * C57BL/6
abnormal T cell differentiation J:135154
decreased CD4-positive, alpha beta T cell number J:135154
Airetm1Mand/Aire+
Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * C57BL/6
abnormal T cell differentiation J:135154
Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?
involves: BALB/c * C57BL/6 * CBA
abnormal thymus morphology J:141379
normal immune system phenotype J:141379
B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
abnormal CD8-positive, alpha beta T cell morphology J:93553
decreased susceptibility to autoimmune diabetes J:93553
Bcl6tm1.1Toka/Bcl6+
Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6 * NZB
decreased T cell proliferation J:174014
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Tg(TcrLCMV)327Sdz/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal T cell number J:63282
decreased double-positive T cell number J:63282
decreased T cell proliferation J:63282
decreased thymocyte number J:63282
increased double-negative T cell number J:63282
Btlatm1Dgra/Btlatm1Dgra
Tg(TcraTcrb)425Cbn/?
involves: C57BL/6
abnormal peripheral T cell anergy J:147751
Btlatm1Dgra/Btlatm1Dgra
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6
abnormal peripheral T cell anergy J:147751
Btlatm1Kmm/Btlatm1Kmm
Tg(DO11.10)10Dlo/?
involves: 129S/SvEv * BALB/c * C3H * C57BL/6
increased T cell proliferation J:84084
Camltm1Rjb/Camltm2Rjb
Tg(Lck-cre)1Cwi/0
Tg(TcraTcrb)1100Mjb/0
involves: 129 * C57BL/6 * DBA/2
abnormal negative T cell selection J:100536
abnormal positive T cell selection J:100536
decreased thymocyte number J:100536
Card11tm1.1Litt/Card11tm1.1Litt
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Tg(TcraTcrb)425Cbn/?
involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6
abnormal T cell activation J:180410
Casp3tm1Mak/Casp3tm1Mak
Tg(TcrLCMV)327Sdz/0
B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz
abnormal CD8-positive, alpha beta T cell morphology J:97650
decreased cell proliferation J:97650
decreased physiological sensitivity to xenobiotic J:97650
Ccr7tm1Rfor/Ccr7tm1Rfor
Tg(DO11.10)10Dlo/?
involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
abnormal cell migration J:123482
abnormal leukocyte migration J:123482
abnormal regulatory T cell physiology J:123482
Cd3etm1.1Geno/Cd3etm1.1Geno
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * C57BL/6J * DBA/2J
abnormal negative T cell selection J:192604
abnormal positive T cell selection J:192604
increased DN3 thymocyte number J:192604
Cd3etm1.1Geno/Cd3etm1.1Geno
Tg(TcrAND)53Hed/0
involves: C57BL/6 * SJL
abnormal CD4-positive T cell differentiation J:192604
abnormal positive T cell selection J:192604
increased DN3 thymocyte number J:192604
Cd3etm1.1Geno/Cd3etm1.1Geno
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6
abnormal positive T cell selection J:192604
abnormal T cell differentiation J:192604
abnormal thymus cell ratio J:192604
decreased double-positive T cell number J:192604
decreased T cell number J:192604
increased DN3 thymocyte number J:192604
Cd3gtm1.1Cage/Cd3gtm1.1Cage
Tg(TcrLCMV)318Sdz/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
abnormal response to infection J:142387
abnormal T cell physiology J:142387
normal immune system phenotype J:142387
Cd4tm1Jrp/Cd4tm1Jrp
Tg(TcrAND)53Hed/0
either: (involves: 129S2/SvPas * C57BL/6 * SJL) or (involves: 129S2/SvPas * C57BL/6 * C57BL/10 * SJL)
abnormal T cell number J:45168
thymus hyperplasia J:45168
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
increased susceptibility to autoimmune diabetes J:93553
Cd5tm1.1Chra/Cd5tm1.1Chra
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: C57BL/6 * FVB/N
decreased interferon-gamma secretion J:189919
decreased interleukin-2 secretion J:189919
decreased T cell proliferation J:189919
decreased T helper 1 cell number J:189919
increased interferon-gamma secretion J:189919
increased interleukin-6 secretion J:189919
increased interleukin-17 secretion J:189919
Cd8atm1Asin/Cd8atm1Asin
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J
abnormal CD8-positive, alpha beta T cell morphology J:125259
Cd8atm1Asin/Cd8atm1Asin
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
abnormal positive T cell selection J:126026
decreased CD4-positive, alpha beta T cell number J:126026
increased CD8-positive, alpha-beta T cell number J:126026
Cd8b1tm1Litt/Cd8b1+
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129S4/SvJae * C57BL/6J * DBA/2
decreased double-positive T cell number J:112551
Cd8b1tm1Litt/Cd8b1tm1Litt
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129S4/SvJae * C57BL/6J * DBA/2
abnormal lymph node cell ratio J:112551
abnormal negative T cell selection J:112551
abnormal positive T cell selection J:112551
decreased CD8-positive, alpha-beta T cell number J:112551
increased CD4-positive, alpha beta T cell number J:112551
Cd28tm1Mak/Cd28tm1Mak
Tg(TcrLCMV)327Sdz/0
involves: 129S2/SvPas * C57BL/6 * DBA/2
abnormal T cell anergy J:123989
decreased cytotoxic T cell cytolysis J:123989
decreased splenocyte proliferation J:123989
decreased T cell proliferation J:123989
Cd28tm1Pjl/Cd28tm1Pjl
Tg(DO11.10)10Dlo/0
involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
abnormal T cell activation J:25536
abnormal T cell proliferation J:25536
abnormal thymocyte activation J:25536
decreased interleukin-2 secretion J:25536
Cd84tm1Pls/Cd84tm1Pls
Tg(TcraTcrb)425Cbn/?
B6.Cg-Cd84tm1Pls Tg(TcraTcrb)425Cbn
abnormal CD4-positive, alpha-beta T cell physiology J:157915
Cd226tm1.1Cln/Cd226tm1.1Cln
Tg(TcraTcrb)1100Mjb/0
B6.Cg-Cd226tm1.1Cln Tg(TcraTcrb)1100Mjb
abnormal T cell activation J:159749
decreased cytotoxic T cell cytolysis J:159749
decreased interferon-gamma secretion J:159749
decreased T cell proliferation J:159749
Cd247tm2.1Lov/Cd247tm2.1Lov
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6J * DBA/2J
abnormal T cell differentiation J:192915
Cd274tm1Shr/Cd274tm1Shr
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6
increased susceptibility to autoimmune diabetes J:153040
Cops5tm1Rpar/Cops5tm1Rpar
Tg(Lck-cre)548Jxm/0
Tg(TcraTcrb)425Cbn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
decreased thymocyte number J:132114
Ctcftm1Laat/Ctcftm1Laat
Tg(Lck-cre)1Cwi/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J
abnormal T cell differentiation J:143271
decreased CD4-positive, alpha beta T cell number J:143271
decreased CD8-positive, alpha-beta T cell number J:143271
decreased double-positive T cell number J:143271
Ctcftm1Laat/Ctcftm1Laat
Tg(Lck-cre)1Cwi/0
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * C57BL/6
abnormal T cell differentiation J:143271
decreased CD4-positive, alpha beta T cell number J:143271
decreased double-positive T cell number J:143271
decreased T cell number J:143271
increased double-negative T cell number J:143271
increased single-positive T cell number J:143271
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcrAND)53Hed/0
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal T cell activation J:119845
increased interleukin-4 secretion J:119845
increased T cell proliferation J:119845
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
normal immune system phenotype J:140448
normal mortality/aging J:140448
normal pigmentation phenotype J:140448
Ctla4tm1All/Ctla4tm1All
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL
abnormal splenocyte physiology J:109887
enlarged spleen J:109887
increased acute inflammation J:109887
insulitis J:109887
normal mortality/aging J:109887
Ctla4tm1All/Ctla4tm1All
Tg(TcrAND)53Hed/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal lymphopoiesis J:119845
abnormal T cell activation J:119845
abnormal T cell subpopulation ratio J:119845
increased CD4-positive, alpha beta T cell number J:119845
increased CD8-positive, alpha-beta T cell number J:119845
premature death J:119845
Ctla4tm1All/Ctla4tm1All
Tg(TcraTcrb)8Rest/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
decreased CD8-positive, alpha-beta T cell number J:140448
increased CD4-positive, alpha beta T cell number J:140448
increased interferon-gamma secretion J:140448
premature death J:140448
variable depigmentation J:140448
Ctla4tm1Shr/Ctla4tm1Shr
Rag2tm1Fwa/Rag2tm1Fwa
Tg(DO11.10)10Dlo/0
involves: 129S/Sv * BALB/c * C3H * C57BL/6
abnormal cytokine secretion J:110446
abnormal T cell physiology J:110446
normal immune system phenotype J:110446
Ctla4tm1Shr/Ctla4tm1Shr
Tg(DO11.10)10Dlo/0
involves: 129S4/SvJae * BALB/c * C3H * C57BL/6
abnormal T cell physiology J:57090
enlarged lymph nodes J:57090
enlarged spleen J:57090
increased T cell proliferation J:57090
Dock2tm1Tsas/Dock2tm1Tsas
Tg(Tcra2B4)1Mmd/?
Tg(Tcrb2B4)1Mmd/?
involves: C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:84581
abnormal T cell physiology J:84581
decreased double-positive T cell number J:84581
E2f2tm1Zubi/E2f2tm1Zubi
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J
abnormal immune system morphology J:76318
abnormal immune system physiology J:76318
enlarged spleen J:76318
increased CD8-positive, alpha-beta T cell number J:76318
increased inflammatory response J:76318
increased susceptibility to autoimmune disorder J:76318
increased T cell proliferation J:76318
premature death J:76318
thymus hypoplasia J:76318
Ebi3Gt716Lex/Ebi3Gt716Lex
Tg(DO11.10)10Dlo/0
involves: 129S5/SvEvBrd * BALB/c * C3H * C57BL/6
abnormal circulating interleukin level J:134148
abnormal T cell differentiation J:134148
decreased susceptibility to bacterial infection J:134148
increased circulating interleukin-17 level J:134148
increased interleukin-17 secretion J:134148
Elavl1tm1Dkon/Elavl1tm1Dkon
Tg(Lck-cre)I57Jxm/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
B6.Cg-Elavl1tm1Dkon Tg(Lck-cre)I57Jxm Tg(TcraH-Y,TcrbH-Y)71Vbo
abnormal negative T cell selection J:148866
increased thymocyte number J:148866
Elk4tm1Rtr/Elk4tm1Rtr
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129/Sv * C57BL/6 * DBA/2J
abnormal positive T cell selection J:88515
decreased CD8-positive, alpha-beta T cell number J:88515
Elk4tm1Rtr/Elk4tm1Rtr
Tg(TcraTcrb)425Cbn/?
involves: 129/Sv * C57BL/6
abnormal positive T cell selection J:88515
abnormal splenic cell ratio J:88515
decreased CD4-positive, alpha beta T cell number J:88515
Elk4tm1Rtr/Elk4tm1Rtr
Tg(TcrLCMV)327Sdz/?
involves: 129/Sv * C57BL/6 * DBA/2
abnormal positive T cell selection J:88515
decreased CD8-positive, alpha-beta T cell number J:88515
Erap1tm1Luc/Erap1tm1Luc
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcrLCMV)327Sdz/Tg(TcrLCMV)327Sdz
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * C57BL/10SgSnAi * DBA/2
normal immune system phenotype J:122479
Ets1tm1Jml/Ets1tm1Jml
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J
decreased CD8-positive, alpha-beta T cell number J:125056
normal immune system phenotype J:125056
increased double-negative T cell number J:125056
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd)33Wnt/0
Tg(Lck-cre)I57Jxm/0
Tg(Tcra2C,Tcrb2C)1Dlo/0
involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL
increased double-negative T cell number J:69617
thymus hypoplasia J:69617
Faslpr/Fas+
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * MRL/Mp
liver inflammation J:72817
normal liver/biliary system phenotype J:72817
normal mortality/aging J:72817
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0
Not Specified
increased susceptibility to autoimmune diabetes J:85985
Fbn1Tsk/Fbn1+
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/10 * DBA/2
emphysema J:57957
normal integument phenotype J:57957
Fbn1Tsk/Fbn1+
Tg(Tcra2C,Tcrb2C)1Dlo/?
involves: C57BL/10 * DBA/2
emphysema J:57957
normal integument phenotype J:57957
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-Il7r)1Asin/?
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
decreased T cell number J:147057
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
decreased T cell number J:147057
Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Not Specified
normal immune system phenotype J:97029
no abnormal phenotype detected J:97029
Gata3tm1Iho/Gata3tm1Iho
Tg(Cd4-cre)1Cwi/0
Tg(DO11.10)10Dlo/0
involves: BALB/c * C3H * C57BL/6 * DBA/2
decreased CD4-positive, alpha beta T cell number J:86996
Gata3tm1Iho/Gata3tm1Iho
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Cwi/0
involves: BALB/c * C3H * C57BL/6
arrested T cell differentiation J:86996
decreased CD4-positive, alpha beta T cell number J:86996
decreased CD8-positive, alpha-beta T cell number J:86996
decreased double-positive T cell number J:86996
small thymus J:86996
Gata3tm1Jfz/Gata3tm1Jfz
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Cd4-cre)1Cwi/0
Tg(Tcra5CC7,Tcrb5CC7)IWep/0
involves: 129S/SvEv * C57BL/6 * DBA/2
abnormal T cell differentiation J:141145
Gimap5m1Btlr/Gimap5m1Btlr
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6J * DBA/2J
decreased CD8-positive, alpha-beta T cell number J:160090
decreased thymocyte number J:160090
Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(DO11.10)10Dlo/0
involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
decreased CD4-positive, alpha beta T cell number J:160613
Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6J * DBA/2J
abnormal CD4-positive, alpha-beta T cell physiology J:160613
abnormal CD8-positive, alpha-beta T cell physiology J:160613
abnormal cell migration J:160613
abnormal positive T cell selection J:160613
decreased CD8-positive, alpha-beta T cell number J:160613
Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * C57BL/6
decreased CD4-positive, alpha beta T cell number J:160613
Gpr15tm1.1Litt/Gpr15tm1.1Litt
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6
abnormal immune system physiology J:199126
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Jtak/0
involves: 129 * BALB/c * C3H * C57BL/6
abnormal T cell differentiation J:161294
decreased CD4-positive, alpha beta T cell number J:161294
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
abnormal T cell differentiation J:161294
decreased CD4-positive, alpha beta T cell number J:161294
decreased CD8-positive, alpha-beta T cell number J:161294
increased CD8-positive, alpha-beta T cell number J:161294
increased double-positive T cell number J:161294
Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl
Mogtm1(cre)Gkl/?
Tg(TcraCl4,TcrbCl4)1Shrm/0
involves: 129/Sv * BALB/c * C57BL/6
abnormal oligodendrocyte morphology J:137838
abnormal optic nerve morphology J:137838
brain inflammation J:137838
CNS inflammation J:137838
demyelination J:137838
hypoactivity J:137838
impaired righting response J:137838
tremors J:137838
weight loss J:137838
Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+
Tg(TcraTcrb)1100Mjb/0
Albtm1(cre/ERT2)Mtz/Alb+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
increased circulating alanine transaminase level J:173806
Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrb+
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
enlarged spleen J:181546
increased B cell number J:181546
premature death J:181546
Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
enlarged liver J:181546
enlarged spleen J:181546
increased B cell derived lymphoma incidence J:181546
increased B cell number J:181546
increased plasmacytoma incidence J:181546
premature death J:181546
Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrb+
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
enlarged spleen J:181546
increased B cell number J:181546
premature death J:181546
Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
enlarged liver J:181546
enlarged spleen J:181546
increased B cell derived lymphoma incidence J:181546
increased B cell number J:181546
increased plasmacytoma incidence J:181546
premature death J:181546
H2-Kbm1/H2-Kbm1
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6
abnormal positive T cell selection J:92867
H2-Kbm5/H2-Kbm5
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6
abnormal positive T cell selection J:133645
H2-T23tm2Cant/H2-T23tm2Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
involves: 129S6/SvEvTac
abnormal CD4-positive, alpha-beta T cell physiology J:142087
increased susceptibility to experimental autoimmune encephalomyelitis J:142087
H2-T23tm3Cant/H2-T23tm3Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
involves: 129S6/SvEvTac * C57BL/6
abnormal CD4-positive, alpha-beta T cell physiology J:142087
H2-T23tm3Cant/H2-T23tm3Cant
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * C57BL/6
abnormal CD4-positive, alpha-beta T cell physiology J:142087
H2b/H2b
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10
abnormal positive T cell selection J:123795
decreased CD4-positive, alpha beta T cell number J:123795
H2b/H2b
Nfkbidtm1Clay/Nfkbidtm1Clay
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
abnormal thymocyte activation J:132071
decreased interleukin-2 secretion J:132071
decreased T cell proliferation J:132071
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
decreased thymocyte number J:131357
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
H2b/H2b
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * C57BL/6
abnormal cytotoxic T cell physiology J:133112
arrested T cell differentiation J:133112
decreased CD4-positive, alpha beta T cell number J:133112
increased CD8-positive, alpha-beta T cell number J:133112
increased T cell proliferation J:133112
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
H2b/H2b
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal double-negative T cell morphology J:131357
abnormal double-positive T cell morphology J:81564
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
decreased double-positive T cell number J:131357
decreased thymocyte number J:131357
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
involves: BALB/c * C57BL/6
abnormal negative T cell selection J:133645
decreased CD8-positive, alpha-beta T cell number J:133645
small thymus J:133645
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
involves: C57BL/6 * NOD * SJL
rheumatoid arthritis J:36815
H2b/H2k
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10
abnormal positive T cell selection J:123795
decreased CD4-positive, alpha beta T cell number J:123795
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * C57BL/10Sg * C57BR/c
abnormal negative T cell selection J:133645
decreased CD8-positive, alpha-beta T cell number J:133645
small thymus J:133645
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss
abnormal negative T cell selection J:133645
decreased CD8-positive, alpha-beta T cell number J:133645
small thymus J:133645
H2d/H2d
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * C57BL/6
arrested T cell differentiation J:133112
decreased CD4-positive, alpha beta T cell number J:133112
decreased CD8-positive, alpha-beta T cell number J:133112
H2d/H2d
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
decreased thymocyte number J:131357
H2d/H2d
Tg(TcraP1.5,TcrbP1.5)29Amsv/0
Trap1atm1.1Jvde/Y
involves: 129 * BALB/cJ * C57BL/10 * DBA/2
abnormal T cell clonal deletion J:180807
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
brain inflammation J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
brain inflammation J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
abnormal axon morphology J:189816
abnormal cytokine secretion J:189816
abnormal motor capabilities/coordination/movement J:189816
axon degeneration J:189816
brain inflammation J:189816
CNS inflammation J:189816
increased CD4-positive, alpha beta T cell number J:189816
increased inflammatory response J:189816
increased interferon-gamma secretion J:189816
increased interleukin-17 secretion J:189816
increased susceptibility to experimental autoimmune encephalomyelitis J:189816
increased T-helper 1 cell number J:189816
increased T-helper 17 cell number J:189816
neuron degeneration J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
brain inflammation J:189816
increased susceptibility to experimental autoimmune encephalomyelitis J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
normal nervous system phenotype J:189816
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD
increased circulating glucose level J:111874
increased susceptibility to autoimmune diabetes J:111874
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
increased susceptibility to autoimmune diabetes J:111874
insulitis J:111874
H2g7/H2g7
Tg(Ins2-Vtcn1)#Xxz/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: C57BL/6 * NOD * SJL
decreased interferon-gamma secretion J:177612
decreased interleukin-17 secretion J:177612
decreased regulatory T cell number J:177612
decreased susceptibility to autoimmune diabetes J:177612
H2g7/H2g7
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
increased susceptibility to autoimmune diabetes J:167508
H2g7/H2g7
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
B6.Cg-H2g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
decreased susceptibility to autoimmune diabetes J:86926
H2g7/H2g7
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
decreased susceptibility to autoimmune diabetes J:111874
insulitis J:111874
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
increased susceptibility to autoimmune diabetes J:111874
H2k/H2k
Tg(TcraTcrbAD10)1Hed/?
involves: C57BL/6 * SJL
increased CD4-positive, alpha beta T cell number J:124701
H2q/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
decreased susceptibility to autoimmune diabetes J:111874
normal digestive/alimentary phenotype J:111874
H2u/H2u
Tg(TCRA)B1Jg/0
Tg(TCRB)C14Jg/0
B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg Tg(TCRB)C14Jg
abnormal double-negative T cell morphology J:92992
abnormal double-positive T cell morphology J:92992
abnormal thymus cell ratio J:92992
absent gamma-delta T cells J:92992
decreased double-positive T cell number J:92992
increased CD4-positive, alpha beta T cell number J:92992
increased double-negative T cell number J:92992
increased T cell derived lymphoma incidence J:92992
H2u/H2u
Tg(TCRA)B1Jg/?
Tg(TCRB)C14Jg/?
involves: C57BL/6 * C57BL/10SnSg * DBA/2 * PL/J
abnormal CD4-positive, alpha-beta T cell physiology J:92991
abnormal effector T cell morphology J:92991
decreased CD8-positive, alpha-beta T cell number J:92991
decreased double-positive T cell number J:92991
increased autoantibody level J:92991
increased CD4-positive, alpha beta T cell number J:92991
increased susceptibility to experimental autoimmune encephalomyelitis J:92991
paralysis J:92991
H2u/H2u
Tg(TCRB)C14Jg/0
B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
abnormal double-negative T cell morphology J:92992
abnormal double-positive T cell morphology J:92992
absent gamma-delta T cells J:92992
Havcr2tm1Vlcg/Havcr2tm1Vlcg
Tg(TcraTcrb)1100Mjb/?
B6.Cg-Havcr2tm1Vlcg Tg(TcraTcrb)1100Mjb
decreased interferon-gamma secretion J:209885
decreased T cell number J:209885
Hc0/Hc0
Tg(TcrbBL17)1Lmor/0
involves: DBA/1J * SWR/J
decreased susceptibility to induced arthritis J:134111
Hc1/?
Tg(TcrbBL17)1Lmor/0
involves: DBA/1J * SWR/J
increased susceptibility to induced arthritis J:134111
Hcls1tm1Wtn/Hcls1tm1Wtn
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal negative T cell selection J:28146
decreased double-positive T cell number J:28146
Hivep2tm1Sis/Hivep2tm1Sis
Tg(DO11.10)10Dlo/?
involves: BALB/cA * C3H * C57BL/6NCrlj * CBA/JNCrlj
abnormal positive T cell selection J:96024
abnormal T-helper 2 cell morphology J:96024
decreased single-positive T cell number J:72249
Icostm1Flv/Icostm1Flv
Tg(TcraTcrb)425Cbn/0
involves: 129S1/Sv * C57BL/6
abnormal cytokine secretion J:112600
Id2tm1Ago/Id2tm1Ago
Tg(TcraTcrb)1100Mjb/0
B6.Cg-Id2tm1Ago Tg(TcraTcrb)1100Mjb
abnormal T cell activation J:116119
Ifngtm1Ts/Ifngtm1Ts
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL
normal immune system phenotype J:196160
normal mortality/aging J:196160
Igh-Jtm1Aigl/Igh-J+
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
abnormal nervous system morphology J:151335
abnormal optic nerve morphology J:151335
abnormal spinal cord morphology J:151335
CNS inflammation J:151335
demyelination J:151335
increased susceptibility to experimental autoimmune encephalomyelitis J:151335
muscle hypertonia J:151335
paralysis J:151335
Igh-Jtm1Aigl/Igh-J+
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal nervous system morphology J:151335
abnormal optic nerve morphology J:151335
abnormal spinal cord morphology J:151335
CNS inflammation J:151335
demyelination J:151335
increased susceptibility to experimental autoimmune encephalomyelitis J:151335
muscle hypertonia J:151335
paralysis J:151335
Igh-Jtm1Aigl/Igh-Jtm1Aigl
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N * SJL/J
increased autoantibody level J:149511
increased susceptibility to experimental autoimmune encephalomyelitis J:149511
Igh-Jtm1Mcdl/Igh-Jtm1Mcdl
Igk-Jtm1Mcdl/Igk-Jtm1Mcdl
Rag1tm1Mom/Rag1tm1Mom
Tg(DO11.10)10Dlo/?
involves: 129S/Sv * BALB/c * C3H * C57BL/6
abnormal spleen germinal center morphology J:100072
abnormal T cell differentiation J:100072
increased IgE level J:100072
increased IgG level J:100072
Ighmtm1Cgn/Ighmtm1Cgn
Tg(TcraR28,TcrbR28)KRNDim/0
involves: 129S2/SvPas * C57BL/6 * NOD * SJL
normal immune system phenotype J:36815
Igktm1Dhu/Igktm1Dhu
Tg(H2-Ea-HA)HACIIAjca/0
Tg(Tcra/Tcrb)1Vbo/0
C.Cg-Igktm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(Tcra/Tcrb)1Vbo
arthritis J:209872
Il2tm1Hor/Il2tm1Hor
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/0
involves: 129P2/OlaHsd * C57BL/10
abnormal T cell number J:120176
increased T-helper 17 cell number J:120176
Il2tm1Hor/Il2tm1Hor
Tcrbtm1Mom/Tcrbtm1Mom
involves: 129P2/OlaHsd * C57BL/6
normal digestive/alimentary phenotype J:135589
normal immune system phenotype J:135589
Il2tm1Hor/Il2tm1Hor
Tg(DO11.10)10Dlo/?
C.Cg-Il2tm1Hor Tg(DO11.10)10Dlo
abnormal regulatory T cell physiology J:88349
increased activated T cell number J:88349
increased T cell proliferation J:88349
premature death J:88349
Il2tm1Hor/Il2tm1Hor
Tg(Pgk1-HA)1.1Vbo/?
Tg(Tcra/Tcrb)1Vbo/?
C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo
abnormal regulatory T cell physiology J:112603
decreased regulatory T cell number J:112603
increased regulatory T cell number J:112603
Il2ratm1Dw/Il2ratm1Dw
Tg(Pgk1-HA)1.1Vbo/?
Tg(Tcra/Tcrb)1Vbo/?
C.Cg-Il2ratm1Dw Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo
abnormal regulatory T cell physiology J:112603
decreased regulatory T cell number J:112603
increased regulatory T cell number J:112603
Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
decreased susceptibility to autoimmune diabetes J:85924
insulitis J:85924
Il6sttm1Thir/Il6sttm1Thir
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129 * C57BL/6 * DBA
abnormal negative T cell selection J:133059
Il13tm1.1Anjm/Il13tm1.1Anjm
Tg(DO11.10)10Dlo/0
involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
abnormal CD4-positive, alpha-beta T cell physiology J:91403
decreased interleukin-13 secretion J:91403
Il15ratm1.1Nsl/Il15ratm1.1Nsl
Tg(TcrAND)53Hed/?
involves: 129X1/SvJ * C57BL/6 * SJL
increased T cell proliferation J:92705
Itktm1Litt/Itktm1Litt
Tg(DO11.10)10Dlo/0
involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J
abnormal T-helper 2 physiology J:129883
Itktm1Litt/Itktm1Litt
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129S4/SvJae * C57BL/6 * DBA/2J
abnormal positive T cell selection J:31230
decreased CD4-positive, alpha beta T cell number J:31230
increased double-positive T cell number J:31230
Itktm1Litt/Itktm1Litt
Tg(TcrAND)53Hed/0
involves: 129S4/SvJae * C57BL/6 * SJL
abnormal lymphocyte morphology J:31230
decreased CD4-positive, alpha beta T cell number J:31230
increased double-negative T cell number J:31230
Itktm1Ljb/Itktm1Ljb
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
involves: 129 * C57BL/10
abnormal CD4-positive T cell differentiation J:93606
decreased interferon-gamma secretion J:93606
decreased interleukin-4 secretion J:93606
decreased interleukin-5 secretion J:93606
decreased interleukin-10 secretion J:93606
Itktm1Ljb/Itktm1Ljb
Tg(Tcra2B4)1Mmd/?
Tg(Tcrb2B4)1Mmd/?
involves: C3H/HeJ * C57BL/6 * C57BL/10
decreased CD4-positive, alpha beta T cell number J:123795
Itktm1Ljb/Itktm1Ljb
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
involves: 129 * C57BL/10
decreased CD4-positive, alpha beta T cell number J:123795
Itktm1Ljb/Itktm1Ljb
Tg(TcraTcrb)1100Mjb/?
involves: 129 * C57BL/6 * C57BL/10
normal immune system phenotype J:113408
Ksr1tm1Shaw/Ksr1tm1Shaw
Tg(DO11.10)10Dlo/0
involves: BALB/c * C3H * C57BL/6
abnormal CD4-positive T cell differentiation J:75739
decreased interleukin-2 secretion J:75739
decreased T cell proliferation J:75739
Lattm6(DTR)Mal/?
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/?
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
abnormal T cell physiology J:138401
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C3H * C57BL/6 * DBA/2J
abnormal positive T cell selection J:114660
abnormal T cell differentiation J:114660
arrested T cell differentiation J:114660
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)425Cbn/0
involves: C3H * C57BL/6
abnormal positive T cell selection J:114660
arrested T cell differentiation J:114660
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)1100Mjb/0
involves: C3H * C57BL/6
abnormal positive T cell selection J:114660
decreased T cell proliferation J:114660
Lcp2tm1.1Wz/Lcp2tm1.1Wz
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * C57BL/6J * DBA/2J
abnormal T cell differentiation J:150304
Lcp2tm3Gak/Lcp2tm3Gak
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2J
abnormal negative T cell selection J:132995
normal immune system phenotype J:132995
increased CD8-positive, alpha-beta T cell number J:132995
increased double-positive T cell number J:132995
Lcp2tm3Gak/Lcp2tm3Gak
Tg(TcrAND)53Hed/?
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal positive T cell selection J:132995
abnormal thymocyte activation J:132995
Lcp2tm4Gak/Lcp2tm4Gak
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N
abnormal negative T cell selection J:132995
increased double-positive T cell number J:132995
Lcp2tm4Gak/Lcp2tm4Gak
Tg(TcrAND)53Hed/?
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal positive T cell selection J:132995
abnormal thymocyte activation J:132995
Lime1tm1Mal/Lime1tm1Mal
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/?
B6.Cg-Rag2tm1Fwa Lime1tm1Mal Tg(TcraH-Y,TcrbH-Y)1Pas
abnormal CD4-positive T cell differentiation J:126321
increased CD4-positive, alpha beta T cell number J:126321
Map2k6tm1Ina/Map2k6tm1Ina
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal thymus cell ratio J:100093
decreased apoptosis J:100093
Map2k6tm1Ina/Map2k6tm1Ina
Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
decreased apoptosis J:100093
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Cd4-cre)1Cwi/0
Tg(TcrAND)53Hed/0
involves: 129/Sv * C57BL/6 * DBA/2 * SJL
abnormal positive T cell selection J:113280
abnormal T cell subpopulation ratio J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(TcraTcrb)1100Mjb/0
involves: 129/Sv * C57BL/6
decreased thymocyte number J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Tg(Lck-cre)1Cwi/0
Tg(TcrAND)53Hed/0
involves: C57BL/6 * DBA/2 * SJL
abnormal positive T cell selection J:113280
abnormal T cell subpopulation ratio J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Tg(TcrAND)53Hed/0
involves: C57BL/6 * DBA/2 * SJL
abnormal double-positive T cell morphology J:113280
abnormal positive T cell selection J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6
decreased thymocyte number J:113280
Mcl1tm1Yen/Mcl1tm1Yen
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
abnormal double-positive T cell morphology J:146246
decreased CD8-positive, alpha-beta T cell number J:146246
Mcl1tm1Yen/Mcl1tm1Yen
Tg(TcraTcrb)425Cbn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal double-positive T cell morphology J:146246
decreased CD4-positive, alpha beta T cell number J:146246
Mertktm1Gkm/Mertktm1Gkm
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
decreased double-positive T cell number J:147153
increased CD8-positive, alpha-beta T cell number J:147153
increased T cell apoptosis J:147153
Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch
increased susceptibility to experimental autoimmune encephalomyelitis J:151335
Mogtm1Dpd/Mogtm1Dpd
Rag2tm1Cgn/Rag2tm1Cgn
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * C57BL/6
increased susceptibility to experimental autoimmune encephalomyelitis J:151335
Mogtm1Dpd/Mogtm1Dpd
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0
SJL.Cg-Mogtm1Dpd Tg(H2-Kb-Tcra,-Tcrb)1640Kurs
decreased susceptibility to experimental autoimmune encephalomyelitis J:149511
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * C57BL/6
abnormal nervous system morphology J:151335
abnormal optic nerve morphology J:151335
abnormal spinal cord morphology J:151335
CNS inflammation J:151335
demyelination J:151335
increased susceptibility to experimental autoimmune encephalomyelitis J:151335
muscle hypertonia J:151335
paralysis J:151335
Myo1gtm1.2Mfk/Myo1gtm1.2Mfk
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * FVB/N * SJL
abnormal T cell physiology J:212451
Ncaph2nes/Ncaph2nes
Tg(TcrHEL3A9)1Mmd/0
C57BL/6-Ncaph2nes Tg(TcrHEL3A9)1Mmd
abnormal double-negative T cell morphology J:123300
abnormal thymus cell ratio J:123300
decreased double-positive T cell number J:123300
Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6
normal immune system phenotype J:205692
Nfatc3tm1Glm/Nfatc3tm1Glm
Tg(DO11.10)10Dlo/?
involves: 129S2/SvPas * BALB/c * C3H * C57BL/6
decreased double-positive T cell number J:50124
increased double-negative T cell number J:50124
small thymus J:50124
Notch1tm1Agt/Notch1tm1Agt
Notch2tm3Grid/Notch2tm3Grid
Tg(TcrAND)53Hed/?
involves: 129/Sv * 129S1/Sv * C57BL/6 * SJL
abnormal humoral immune response J:123631
abnormal response to infection J:123631
decreased interleukin-4 secretion J:123631
Nr3c1tm1.1Jda/Nr3c1tm1.1Jda
Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(Lck-cre)548Jxm/0
Tg(TcrAND)53Hed/0
B6.Cg-Rag2tm1.1Cgn Nr3c1tm1.1Jda Tg(Lck-cre)548Jxm Tg(TcrAND)53Hed
decreased double-positive T cell number J:189951
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)425Cbn/0
involves: C57BL/6
abnormal T cell subpopulation ratio J:158947
decreased CD8-positive, alpha-beta T cell number J:158947
increased CD4-positive, alpha beta T cell number J:158947
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)1100Mjb/0
involves: 129P2/OlaHsd * C57BL/6
abnormal T cell subpopulation ratio J:158947
decreased CD8-positive, alpha-beta T cell number J:158947
increased CD4-positive, alpha beta T cell number J:158947
Pdcd1tm1.1Shr/Pdcd1tm1.1Shr
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6
abnormal immune tolerance J:153040
decreased T cell proliferation J:153040
increased susceptibility to autoimmune diabetes J:153040
increased T cell proliferation J:153040
insulitis J:153040
pancreas inflammation J:153040
vasculitis J:153040
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas
decreased susceptibility to experimental autoimmune encephalomyelitis J:140751
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
increased susceptibility to experimental autoimmune encephalomyelitis J:222944
Pigrtm1Ohw/Pigrtm1Ohw
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
decreased lymphocyte cell number J:97824
normal immune system phenotype J:97824
increased IgA level J:97824
Pik3cgtm1Dwu/Pik3cgtm1Dwu
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6
abnormal CD8-positive, alpha-beta T cell physiology J:131923
abnormal response to infection J:131923
normal immune system phenotype J:131923
Pip5k1ctm1.2Ref/Pip5k1ctm1.2Ref
Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6
abnormal T cell physiology J:164732
decreased B cell number J:164732
decreased dendritic cell number J:164732
increased interferon-gamma secretion J:164732
increased interleukin-2 secretion J:164732
increased T cell proliferation J:164732
Plcg1tm1Gcrp/Plcg1tm1Rwen
Tg(Cd4-cre)1Cwi/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129X1/SvJ * C57BL/6 * DBA/2
decreased CD8-positive, alpha-beta T cell number J:157757
decreased double-negative T cell number J:157757
increased CD8-positive, alpha-beta T cell number J:157757
increased double-positive T cell number J:157757
thymus hyperplasia J:157757
Plxna1tm1Kik/Plxna1tm1Kik
Tg(TcraTcrb)425Cbn/?
involves: BALB/c * C57BL/6
decreased T cell proliferation J:161856
Ppp4ctm1Tht/Ppp4ctm1Tht
Tg(Lck-cre)548Jxm/0
Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6 * CBA
abnormal positive T cell selection J:117684
decreased double-positive T cell number J:117684
decreased single-positive T cell number J:117684
Prkcqtm1Litt/Prkcqtm1Litt
Tg(DO11.10)10Dlo/0
involves: 129 * BALB/c * C3H * C57BL/6
decreased T cell apoptosis J:141930
Prkcqtm1Litt/Prkcqtm1Litt
Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
abnormal T cell anergy J:123989
decreased cytotoxic T cell cytolysis J:123989
decreased splenocyte proliferation J:123989
decreased T cell proliferation J:123989
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
decreased thymocyte number J:236298
increased double-positive T cell number J:236298
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)425Cbn/0
involves: 129 * BALB/c * C57BL/6
decreased thymocyte number J:236298
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)1100Mjb/0
involves: 129 * C57BL/6
decreased thymocyte number J:236298
Prkdcscid/Prkdcscid
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Prkdcscid Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
abnormal CD4-positive, alpha beta T cell morphology J:93553
increased susceptibility to autoimmune diabetes J:93553
Prkdcscid/Prkdcscid
Tg(Tcrb)93Vbo/0
involves: C57BL/Lia * CB17 * CBA/BrA
abnormal CD4-positive, alpha beta T cell morphology J:111476
abnormal CD8-positive, alpha beta T cell morphology J:111476
abnormal double-positive T cell morphology J:111476
abnormal single-positive T cell number J:111476
abnormal T cell differentiation J:111476
Prkdcscid/Prkdcscid
Tg(TcrLCMV)327Sdz/?
NOD.Cg-Emv30b Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
normal immune system phenotype J:71050
Prss16tm1Mal/Prss16+
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/?
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
abnormal positive T cell selection J:148034
decreased CD4-positive, alpha beta T cell number J:148034
decreased single-positive T cell number J:148034
lymph node hypoplasia J:148034
Prss16tm1Mal/Prss16tm1Mal
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/?
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
abnormal positive T cell selection J:148034
decreased CD4-positive, alpha beta T cell number J:148034
decreased double-positive T cell number J:148034
decreased single-positive T cell number J:148034
lymph node hypoplasia J:148034
spleen hypoplasia J:148034
thymus hypoplasia J:148034
Psmb8tm1Hjf/Psmb8tm1Hjf
Tg(TcraTcrb)1100Mjb/?
involves: 129P2/OlaHsd * C57BL/6
decreased CD8-positive, alpha-beta T cell number J:107657
Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * C57BL/6J * DBA/2J
normal immune system phenotype J:176519
Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6
increased CD4-positive, alpha beta T cell number J:176519
increased T cell proliferation J:176519
Ptprcltng/Ptprctm1Mak
Tg(TcraTcrb)425Cbn/0
involves: 129/Sv * BALB/c * C57BL/6
decreased CD4-positive, alpha beta T cell number J:158876
thymus hypoplasia J:158876
Ptprctm1Mak/Ptprctm1Mak
Tg(TcraTcrb)425Cbn/0
involves: 129/Sv * BALB/c * C57BL/6
decreased CD4-positive, alpha beta T cell number J:158876
Rac2tm1Mddw/Rac2tm1Mddw
Tg(TcrAND)53Hed/0
involves: 129S/SvEv * C57BL/6 * SJL
abnormal T cell activation J:119437
decreased circulating interleukin-2 level J:119437
decreased T cell proliferation J:119437
Rag1tm1Bal/Rag1tm1Bal
Tg(TcraTcrb)1100Mjb/?
involves: 129S4/SvJae * C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:133645
decreased CD4-positive, alpha beta T cell number J:133645
increased CD8-positive, alpha-beta T cell number J:133645
Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
Tg(TcrAND)53Hed/0
involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL
decreased CD4-positive, alpha beta T cell number J:113270
Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
increased T cell derived lymphoma incidence J:47667
premature death J:47667
Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0
involves: 129 * C57BL/6
arrested T cell differentiation J:140121
decreased double-positive T cell number J:140121
increased T cell apoptosis J:140121
thymus hypoplasia J:140121
Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
increased T cell derived lymphoma incidence J:47667
premature death J:47667
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra,Tcrb)HRCAll/0
B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll
abnormal T cell differentiation J:131347
abnormal T cell subpopulation ratio J:131347
absent CD4-positive, alpha beta T cells J:131347
increased CD8-positive, alpha-beta T cell number J:131347
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
increased susceptibility to autoimmune diabetes J:94192
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
decreased CD4-positive, alpha beta T cell number J:111874
decreased lymphocyte cell number J:111874
decreased pancreatic beta cell number J:111874
decreased thymus weight J:111874
increased circulating glucose level J:111874
increased double-positive T cell number J:111874
increased susceptibility to autoimmune diabetes J:111874
Rag1tm1Mom/Rag1tm1Mom
Tyrp1B-w/Tyrp1B-w
X/Tg(Tcra,Tcrb)9Rest
involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6
altered tumor susceptibility J:138466
Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
involves: C57BL/6 * DBA/2
autoimmune response J:134764
CNS inflammation J:134764
demyelination J:134764
hindlimb paralysis J:134764
Rag2tm1Fwa/Rag2tm1Fwa
TcraLn3Jae/Tcra+
TcrbLn3Jae/Tcrb+
involves: 129S/SvEv * 129S4/SvJae * C57BL/6
abnormal double-negative T cell morphology J:143006
absent gamma-delta T cells J:143006
decreased CD4-positive, alpha beta T cell number J:143006
increased CD8-positive, alpha-beta T cell number J:143006
Rag2tm1Fwa/Rag2tm1Fwa
TcrbLn3Jae/Tcrb+
involves: 129S/SvEv * 129S4/SvJae * C57BL/6
abnormal double-negative T cell morphology J:143006
absent gamma-delta T cells J:143006
decreased CD4-positive, alpha beta T cell number J:143006
increased double-positive T cell number J:143006
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Cd4-NPM/ALK)N1Ingh/0
Tg(TcraTcrb)1100Mjb/0
involves: 129S/SvEv * C57BL/6 * Swiss Webster
increased gastrointestinal stromal tumor incidence J:235890
increased hepatocellular carcinoma incidence J:235890
increased sarcoma incidence J:235890
Rag2tm1Fwa/Rag2tm1Fwa
Tg(DO11.10)10Dlo/0
involves: 129S/SvEv * BALB/c * C3H * C57BL/6
normal immune system phenotype J:110446
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Themis5AT161/Themis5AT161
involves: 129S/SvEv * C57BL/6
arrested T cell differentiation J:151076
increased double-positive T cell number J:151076
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0
involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2
abnormal CD4-positive T cell differentiation J:125548
abnormal positive T cell selection J:125548
decreased CD4-positive, alpha beta T cell number J:125548
increased double-positive T cell number J:125548
thymus hyperplasia J:125548
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraCN.B1,TcrbCN.B1)SM1Jen/0
involves: 129S/SvEv * C57BL/6
increased susceptibility to bacterial infection induced morbidity/mortality J:162539
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S/SvEv * C57BL/6J * DBA/2J
abnormal CD8-positive, alpha beta T cell morphology J:125259
abnormal CD8-positive, alpha-beta T cell physiology J:125259
abnormal cytotoxic T cell physiology J:66565
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themis5AT161/Themis5AT161
involves: 129S/SvEv * C57BL/6 * DBA/2
decreased single-positive T cell number J:151076
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraTcrbNY8.3)1Pesa/0
NOD.Cg-Rag2tm1Fwa Tg(TcraTcrbNY8.3)1Pesa
increased circulating glucose level J:94192
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcrHEL3A9)1Mmd/0
involves: 129S/SvEv * C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:78309
abnormal double-positive T cell morphology J:78309
abnormal T cell activation J:78309
abnormal T cell proliferation J:78309
abnormal thymus cell ratio J:78309
decreased CD4-positive, alpha beta T cell number J:78309
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcrHEL3A9)1Mmd/0
Tg(TLK2mHEL)2Ccg/0
involves: 129S/SvEv * C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:78309
abnormal CD4-positive, alpha-beta T cell physiology J:78309
abnormal T cell activation J:78309
abnormal T cell proliferation J:78309
decreased CD4-positive, alpha beta T cell number J:78309
decreased double-positive T cell number J:78309
thyroid gland inflammation J:78309
Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/6J * DBA/2J
decreased single-positive T cell number J:225109
increased double-positive T cell number J:225109
Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Tg(TcraTcrb)425Cbn/?
involves: C57BL/6 * BALB/c
abnormal CD4-positive T cell differentiation J:225109
Rhohtm1Brak/Rhohtm1Brak
Tg(TcraTcrb)425Cbn/?
involves: 129/Sv * C57BL/6
decreased CD4-positive, alpha beta T cell number J:143161
normal immune system phenotype J:143161
Rnf128tm1.1Flv/Rnf128tm1.1Flv
Tg(TcraTcrb)425Cbn/0
involves: 129S6/SvEvTac * BALB/c * C57BL/6
abnormal peripheral T cell anergy J:153216
decreased T cell proliferation J:153216
increased circulating interleukin-2 level J:153216
Rnf128tm1.1Flv/Y
Tg(TcraTcrb)425Cbn/0
involves: 129S6/SvEvTac * BALB/c * C57BL/6
abnormal peripheral T cell anergy J:153216
decreased T cell proliferation J:153216
increased circulating interleukin-2 level J:153216
Rnf128tm1Cdon/Rnf128tm1Cdon
Tg(TcraTcrb)425Cbn/0
involves: 129 * BALB/c * C57BL/6
abnormal immune tolerance J:160681
increased interferon-gamma secretion J:160681
increased interleukin-2 secretion J:160681
increased splenocyte proliferation J:160681
Serpina3gtm1.1Arp/Serpina3gtm1.1Arp
Tg(TcrLCMV)#Sdz/0
involves: C57BL/6 * DBA/2
decreased T cell proliferation J:189782
Serpinb9tm1Arp/Serpinb9tm1Arp
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6
abnormal response to transplant J:113349
Sh2d1atm1Pls/Sh2d1atm1Pls
Slamf6tm1Pls/Slamf6tm1Pls
Tg(TcraTcrb)1100Mjb/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
normal immune system phenotype J:187431
Sh2d1atm1Pls/Sh2d1atm1Pls
Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
involves: BALB/c * C3H * C57BL/6
abnormal cytokine secretion J:90484
Sh2d1atm1Pls/Sh2d1atm1Pls
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * C57BL/6
abnormal CD4-positive, alpha-beta T cell physiology J:157915
Sh2d1atm1Pls/Sh2d1atm1Pls
Tg(TcraTcrb)1100Mjb/0
involves: 129S6/SvEvTac * C57BL/6
abnormal cytotoxic T cell physiology J:187431
decreased cytotoxic T cell cytolysis J:187431
decreased interferon-gamma secretion J:187431
Sit1tm1Lsmn/Sit1tm1Lsmn
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/6 * C57BL/6J * DBA/2J
abnormal CD8-positive, alpha beta T cell morphology J:100408
abnormal positive T cell selection J:100408
abnormal T cell differentiation J:100408
Sit1tm1Lsmn/Sit1tm1Lsmn
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6
abnormal positive T cell selection J:100408
abnormal T cell selection J:100408
thymus hypoplasia J:100408
Slatm1Weis/Slatm1Weis
Tg(DO11.10)10Dlo/0
involves: 129 * BALB/c * C3H * C57BL/6
abnormal positive T cell selection J:71804
abnormal T cell differentiation J:71804
Slamf1tm1Cpt/Slamf1tm1Cpt
Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
involves: BALB/c * C3H * C57BL/6
abnormal cytokine secretion J:90484
Slamf6tm1Pls/Slamf6tm1Pls
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * C57BL/6J
normal immune system phenotype J:187431
Stat2tm1Jdf/Stat2tm1Jdf
Tg(DO11.10)10Dlo/0
C.Cg-Stat2tm1Jdf Tg(DO11.10)10Dlo
normal immune system phenotype J:95855
Tagln2tm1Cdj/Tagln2tm1Cdj
Tg(TcraTcrb)425Cbn/0
involves: 129S4/SvJae * C57BL/6
abnormal T cell activation J:256656
Tagln2tm1Cdj/Tagln2tm1Cdj
Tg(TcraTcrb)1100Mjb/0
involves: 129S4/SvJae * C57BL/6
abnormal T cell activation J:256656
Tapbptm1Luc/Tapbptm1Luc
Tg(TcraTcrb)1100Mjb/?
involves: 129S6/SvEvTac
normal immune system phenotype J:64177
Tapbptm1Luc/Tapbptm1Luc
Tg(TcraTcrb)1100Mjb/?
involves: 129S6/SvEvTac * C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:64177
abnormal CD8-positive, alpha beta T cell morphology J:64177
abnormal negative T cell selection J:64177
abnormal positive T cell selection J:64177
normal immune system phenotype J:64177
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Tg(TcrAND)53Hed/0
involves: 129S4/SvJae * C57BL/6 * SJL
normal immune system phenotype J:75746
normal neoplasm J:75746
Tcf12tm2Zhu/Tcf12tm2Zhu
Tg(TcrAND)53Hed/0
involves: C57BL/6 * SJL
abnormal CD4-positive, alpha beta T cell morphology J:120411
abnormal T cell subpopulation ratio J:120411
arrested T cell differentiation J:120411
increased T cell number J:120411
Tcra-Jtm1Kgwa/Tcra-Jtm1Kgwa
Tg(Tcrb2B4)1Mmd/0
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
abnormal T cell differentiation J:50143
increased double-positive T cell number J:50143
TcraLn1Ogu/Tcra+
TcrbLn1Ogu/Tcrb+
involves: 129/Sv * C57BL/6
abnormal T cell morphology J:152069
increased body weight J:152069
TcraLn2Ogu/Tcra+
TcrbLn2Ogu/Tcrb+
involves: 129/Sv * C57BL/6
abnormal T cell morphology J:152069
increased body weight J:152069
TcraLn3Jae/Tcra+
TcrbLn3Jae/Tcrb+
B6.Cg-TcrbLn3Jae TcraLn3Jae
abnormal double-negative T cell morphology J:143006
abnormal T cell differentiation J:143006
absent gamma-delta T cells J:143006
decreased CD4-positive, alpha beta T cell number J:143006
decreased double-positive T cell number J:143006
increased CD8-positive, alpha-beta T cell number J:143006
thymus hypoplasia J:143006
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2b/H2b
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal double-negative T cell morphology J:131357
abnormal double-positive T cell morphology J:81564
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
decreased double-positive T cell number J:131357
decreased thymocyte number J:131357
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2d/H2d
Ptcratm1Vbo/Ptcratm1Vbo
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
decreased thymocyte number J:131357
Tcratm1Mom/Tcratm1Mom
Tcrbtm1Mom/Tcrbtm1Mom
involves: 129 * BALB/c * C57BL/6
arrested T cell differentiation J:3206
decreased double-positive T cell number J:3206
thymus hypoplasia J:3206
Tcrbtm1Mom/Tcrb+
Tg(SOD1*G93A)1Gur/0
B6.Cg-Tcrbtm1Mom Tg(SOD1*G93A)1Gur/J
abnormal microglial cell physiology J:143173
motor neuron degeneration J:143173
premature death J:143173
weight loss J:143173
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
abnormal respiratory system physiology J:125656
abnormal transitional stage B cell morphology J:187766
decreased autoantibody level J:187766
decreased IgE level J:125656
decreased IgG1 level J:125656
decreased IgG level J:125656, J:187766
decreased plasma cell number J:187766
decreased T cell number J:187766
increased B cell number J:187766
increased follicular B cell number J:187766
increased IgM level J:187766
increased immature B cell number J:187766
increased marginal zone B cell number J:187766
increased mature B cell number J:187766
increased transitional stage T2 B cell number J:187766
increased transitional stage T3 B cell number J:187766
renal glomerular immunoglobulin deposits J:187766
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
FVB.129P2-Tcrbtm1Mom Tcrdtm1Mom
normal immune system phenotype J:75915
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
involves: 129 * BALB/c * C57BL/6
absent CD4-positive, alpha beta T cells J:3206
absent CD8-positive, alpha-beta T cells J:3206
arrested T cell differentiation J:3206
colitis J:15221
decreased double-positive T cell number J:3206
thymus hypoplasia J:3206
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
involves: 129P2/OlaHsd
decreased IgA level J:97824
decreased lymphocyte cell number J:97824
normal immune system phenotype J:97824
increased T cell number J:97824
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
involves: 129P2/OlaHsd * C57BL/6
abnormal respiratory system morphology J:119344
abnormal respiratory system physiology J:119344
abnormal response to infection J:119344
decreased IgG level J:119344
normal immune system phenotype J:126867
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
B6.129P2-Tcrbtm1Mom Igh-Jtm2(3H9-VDJ*)Mwg Tcrdtm1Mom
increased anti-double stranded DNA antibody level J:142389
increased marginal zone B cell number J:142389
spleen hypoplasia J:142389
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
abnormal glomerular capillary morphology J:187766
abnormal transitional stage B cell morphology J:187766
decreased IgG level J:187766
decreased T cell number J:187766
normal immune system phenotype J:187766
increased anti-chromatin antibody level J:187766
increased anti-double stranded DNA antibody level J:187766
increased anti-histone antibody level J:187766
increased autoantibody level J:187766
increased IgM level J:187766
increased immature B cell number J:187766
increased marginal zone B cell number J:187766
mesangial cell hyperplasia J:187766
renal glomerular immunoglobulin deposits J:187766
Tcrbtm1Mom/Tcrbtm1Mom
Tg(H2-K-Cd86)7All/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal B cell differentiation J:112475
abnormal B cell morphology J:112475
decreased B cell number J:112475
normal hematopoietic system phenotype J:112475
Tcrbtm1Mom/Tcrbtm1Mom
Tg(H2-K-Cd86)27All/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
normal hematopoietic system phenotype J:112475
Tcrbtm1Mom/Tcrbtm1Mom
Tg(KRT5-rtTA)1Glk/0
Tg(tetO/CMV-Tslp)#Sfz/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N
abnormal dermal layer morphology J:100506
decreased IgE level J:100506
skin inflammation J:100506
thick epidermis J:100506
Tcrbtm2Slek/Tcrbtm2Slek
Trbv13-2tm1(CD2)Zhu/Trbv13-2tm1(CD2)Zhu
involves: 129 * C57BL/6
abnormal T cell differentiation J:121608
Tespa1tm1Lrgl/Tespa1tm1Lrgl
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6 * DBA/2J
decreased CD8-positive, alpha-beta T cell number J:186446
Tespa1tm1Lrgl/Tespa1tm1Lrgl
Tg(TcraTcrb)425Cbn/0
B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)425Cbn
abnormal T cell differentiation J:186446
decreased CD4-positive, alpha beta T cell number J:186446
decreased CD8-positive, alpha-beta T cell number J:186446
Tespa1tm1Lrgl/Tespa1tm1Lrgl
Tg(TcraTcrb)1100Mjb/0
B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)1100Mjb
abnormal T cell differentiation J:186446
decreased CD4-positive, alpha beta T cell number J:186446
decreased CD8-positive, alpha-beta T cell number J:186446
Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(Alb1-HBV)66Bri/0
Tg(TcrLCMV)318Sdz/0
involves: C57BL/6 * C57BL/10 * DBA/2
liver inflammation J:162605
Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(TcrLCMV)318Sdz/0
involves: C57BL/6 * DBA/2
decreased CD8-positive, alpha-beta T cell number J:162605
Tg(CD2-Ceacam1*4L)1Rsb/0
Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6
abnormal CD4-positive, alpha-beta T cell physiology J:116136
Tg(CD2-Mir181d)38Oers/0
Tg(TcraTcrb)425Cbn/0
involves: C3H * C57BL/6
decreased T cell number J:212571
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
abnormal positive T cell selection J:126026
decreased CD4-positive, alpha beta T cell number J:126026
increased CD8-positive, alpha-beta T cell number J:126026
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
involves: BALB/c * C57BL/10
decreased CD8-positive, alpha-beta T cell number J:113713
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
involves: C57BL/10
abnormal positive T cell selection J:113713
increased CD8-positive, alpha-beta T cell number J:113713
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
involves: C57BL/10 * CBA/Ca
decreased CD8-positive, alpha-beta T cell number J:113713
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt/0
involves: C57BL/6 * C57BL/10
abnormal T cell clonal deletion J:217939
decreased thymocyte apoptosis J:217939
enlarged lymph nodes J:217939
increased T cell number J:217939
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
Tg(LCKprBCL2)36Sjk/0
involves: C57BL/6 * C57BL/10
abnormal T cell clonal deletion J:217939
decreased thymocyte apoptosis J:217939
Tg(CD2-Zbtb7b)C8Rbo/?
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/6 * DBA/2J
abnormal T cell differentiation J:97610
Tg(CD2-Zbtb7b)C8Rbo/?
Tg(TcrLCMV)327Sdz/?
involves: C57BL/6 * DBA/2J
abnormal T cell differentiation J:97610
Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * C57BL/6J * DBA/2J
abnormal T cell clonal deletion J:217939
decreased thymocyte apoptosis J:217939
Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
involves: C57BL/6 * DBA/2 * SJL
abnormal gait J:134764
abnormal locomotor activation J:134764
abnormal locomotor coordination J:134764
abnormal motor capabilities/coordination/movement J:134764
CNS inflammation J:134764
forelimb paralysis J:134764
impaired balance J:134764
impaired coordination J:134764
increased sensitivity to induced morbidity/mortality J:134764
increased susceptibility to experimental autoimmune encephalomyelitis J:134764
lethargy J:134764
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Traf6tm2Ywc/Traf6tm2Ywc
involves: C57BL/6 * DBA/2
abnormal lymphocyte anergy J:130882
increased interleukin-2 secretion J:130882
Tg(Cd4-NPM/ALK)N1Ingh/0
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * Swiss Webster
abnormal double-negative T cell morphology J:235890
abnormal thymus morphology J:235890
increased gastrointestinal stromal tumor incidence J:235890
increased hepatocellular carcinoma incidence J:235890
increased sarcoma incidence J:235890
increased T cell derived lymphoma incidence J:235890
premature death J:235890
Tg(Cd8aCd8b)3Erob/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * DBA/2
abnormal CD4-positive, alpha beta T cell morphology J:93004
abnormal CD8-positive, alpha-beta T cell differentiation J:93004
increased CD8-positive, alpha-beta T cell number J:93004
Tg(CMV-TcrAHIII12.2)1Ecol/0
C57BL/6-Tg(CMV-TcrAHIII12.2)1Ecol
no abnormal phenotype detected J:94077
Tg(CMV-TcrAHIII12.2)1Ecol/Tg(CMV-TcrAHIII12.2)1Ecol
C57BL/6-Tg(CMV-TcrAHIII12.2)1Ecol
no abnormal phenotype detected J:94077
Tg(DO11.10)10Dlo/?
involves: BALB/c * C3H * C57BL/6
abnormal thymus physiology J:70572
decreased CD4-positive, alpha beta T cell number J:70572
decreased double-positive T cell number J:70572
Tg(DO11.10)10Dlo/0
Crlf2tm1Wjl/Crlf2tm1Wjl
involves: 129 * BALB/c * C3H * C57BL/6
decreased inflammatory response J:107431
Tg(DO11.10)10Dlo/?
Toxtm1.1Kay/Toxtm1.1Kay
involves: 129S/Sv * BALB/c * C3H * C57BL/6
arrested T cell differentiation J:131287
decreased T cell number J:131287
Tg(H2-Ea-HA)HACIIAjca/0
Tg(Tcra/Tcrb)1Vbo/0
C.Cg-Tg(H2-Ea-HA)HACIIAjca Tg(Tcra/Tcrb)1Vbo
abnormal articular cartilage morphology J:209872
abnormal CD4-positive, alpha beta T cell morphology J:209872
abnormal circulating cytokine level J:209872
abnormal lung morphology J:209872
arthritis J:209872
heart inflammation J:209872
increased circulating interleukin-6 level J:209872
increased IgG level J:209872
joint inflammation J:209872
kidney inflammation J:209872
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0
SJL.FVB-Tg(H2-Kb-Tcra,-Tcrb)1640Kurs
abnormal cytokine level J:149511
ataxia J:149511
brain inflammation J:149511
CNS inflammation J:149511
demyelination J:149511
increased autoantibody level J:149511
increased susceptibility to experimental autoimmune encephalomyelitis J:149511
increased T-helper 1 cell number J:149511
increased T-helper 17 cell number J:149511
limb paralysis J:149511
Tg(H2KePCC)2403Stoe/?
Tg(TcraTcrbAD10)1Hed/?
involves: C57BL/6 * SJL
abnormal immune tolerance J:92997
abnormal T cell anergy J:92997
decreased CD4-positive, alpha beta T cell number J:92997
Tg(H2KmPCC)2939Stoe/0
Tg(Tcra2B4)1Mmd/0
Tg(Tcrb2B4)1Mmd/0
involves: C3H/HeJ * C57BL/6 * SJL
abnormal T cell differentiation J:50143
decreased T cell proliferation J:50143
decreased thymocyte number J:50143
Tg(H2KmPCC)2939Stoe/?
Tg(TcrAND)53Hed/?
involves: C57BL/6 * SJL
abnormal immune tolerance J:92997
abnormal T cell anergy J:92997
decreased CD4-positive, alpha beta T cell number J:92997
Tg(H2KmPCC)2939Stoe/?
Tg(TcraTcrbAD10)1Hed/?
involves: C57BL/6 * SJL
abnormal immune tolerance J:92997
abnormal T cell anergy J:92997
decreased CD4-positive, alpha beta T cell number J:92997
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
involves: C57BL/6 * DBA/2
abnormal gait J:134764
abnormal locomotor activation J:134764
abnormal locomotor coordination J:134764
abnormal motor capabilities/coordination/movement J:134764
CNS inflammation J:134764
forelimb paralysis J:134764
hindlimb paralysis J:134764
impaired balance J:134764
impaired coordination J:134764
increased sensitivity to induced morbidity/mortality J:134764
increased susceptibility to experimental autoimmune encephalomyelitis J:134764
lethargy J:134764
Tg(Igk-Eik-H2-Ead)1Flv/0
Tg(Tcra1H3.1,Tcrb1H3.1)1Vire/0
involves: C57BL/6 * SJL
decreased double-positive T cell number J:124574
thymus hypoplasia J:124574
Tg(ILK3mHEL)3Ccg/0
Tg(TcrHEL3A9)1Mmd/0
involves: C57BL/6JSfd * C57BL/10Sg * C57BR/cd
abnormal CD4-positive, alpha beta T cell morphology J:78309
abnormal CD4-positive, alpha-beta T cell physiology J:78309
abnormal T cell activation J:78309
abnormal T cell proliferation J:78309
decreased CD4-positive, alpha beta T cell number J:78309
insulitis J:78309
Tg(Ins1-Cd80)378Psoh/0
Tg(Ins2-GP)#Psoh/0
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6 * DBA/2 * FVB/N
absent pancreatic beta cells J:209714
cachexia J:209714
hyperglycemia J:209714
insulitis J:209714
ketosis J:209714
periinsulitis J:209714
premature death J:209714
Tg(Ins1-Cd80)378Psoh/0
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6 * DBA/2 * FVB/N
normal homeostasis/metabolism phenotype J:209714
Tg(Ins2-GP)#Psoh/0
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6 * DBA/2
abnormal B cell selection J:81285
normal homeostasis/metabolism phenotype J:209714
hyperglycemia J:81285
increased urine glucose level J:81285
Tg(Ins2-HA)165Bri/?
Tg(TcraCl4,TcrbCl4)1Shrm/?
involves: BALB/c * C57BL/6 * C57BL/10
hyperglycemia J:99756
insulitis J:99756
postnatal lethality, complete penetrance J:99756
Tg(Ins2-HA)165Bri/0
Tg(TcraCl4,TcrbCl4)1Shrm/0
involves: BALB/c * C57BL/6 * C57BL/10 * DBA/2
abnormal pancreatic islet morphology J:99756
hyperglycemia J:99756
insulitis J:99756
postnatal lethality J:99756
Tg(Ins2-OVA)307Wehi/0
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * C57BL/6JWehi
autoimmune response J:99451
decreased pancreatic beta cell number J:99451
increased urine glucose level J:99451
Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * C57BL/6
decreased CD4-positive, alpha beta T cell number J:135154
increased double-positive T cell number J:135154
Tg(KLK4mHEL)6Ccg/0
Tg(TcrHEL3A9)1Mmd/0
involves: C57BL/6 * C57BL/10 * C57BR/cd
decreased CD4-positive, alpha beta T cell number J:78309
decreased double-positive T cell number J:78309
Tg(Lck-CrmA)1Hed/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
BALB/c * C57BL/6
normal immune system phenotype J:100451
Tg(Lck-FADD)1Hed/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: BALB/c * C57BL/6J * C57L/J * DBA/2J
normal immune system phenotype J:100451
Tg(LCK-NFKBIA)5Dwb/?
Tg(Tcra,Tcrb)1Mcd/?
involves: BALB/c * C57BL/6 * DBA/2
decreased interferon-gamma secretion J:145531
Tg(Lck-Stk17b)26.1Wals/?
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/6 * C57BL/10
abnormal T cell differentiation J:149973
decreased CD8-positive, alpha-beta T cell number J:149973
decreased thymocyte number J:149973
increased CD8-positive, alpha-beta T cell number J:149973
Tg(LCKprBCL2)36Sjk/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * C57BL/6J * DBA/2J
abnormal T cell clonal deletion J:217939
decreased thymocyte apoptosis J:217939
Tg(ML5sHEL)5Ccg/0
Tg(TcrHEL3A9)1Mmd/0
involves: C57BL/6 * C57BL/10 * C57BR/cd
abnormal CD4-positive, alpha beta T cell morphology J:78309
abnormal CD4-positive, alpha-beta T cell physiology J:78309
abnormal T cell activation J:78309
abnormal T cell proliferation J:78309
decreased CD4-positive, alpha beta T cell number J:78309
decreased double-positive T cell number J:78309
Tg(ML5sHEL)5Ccg/0
Tg(TcrHEL3A9)1Mmd/0
Tg(TLK2mHEL)2Ccg/0
involves: C57BL/6JSfd * C57BL/10 * C57BR/cd
abnormal CD4-positive, alpha beta T cell morphology J:78309
abnormal CD4-positive, alpha-beta T cell physiology J:78309
abnormal T cell activation J:78309
abnormal T cell proliferation J:78309
decreased CD4-positive, alpha beta T cell number J:78309
decreased double-positive T cell number J:78309
thyroid gland inflammation J:78309
Tg(Pgk1-HA)1.1Vbo/?
Tg(Tcra/Tcrb)1Vbo/?
C.Cg-Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo
abnormal regulatory T cell physiology J:112603
increased regulatory T cell number J:112603
Tg(Pgk1-HA)1.1Vbo/?
Tg(Tcra/Tcrb)1Vbo/?
involves: 129 * BALB/c * C57BL/6J * DBA/2J
decreased CD4-positive, alpha beta T cell number J:125750
increased double-positive T cell number J:125750
increased regulatory T cell number J:125750
Tg(Tcra2C,Tcrb2C)1Dlo/?
involves: C57BL/6 * SJL
abnormal CD8-positive, alpha beta T cell morphology J:125259
Tg(Tcra2C,Tcrb2C)1Dlo/?
involves: C57L * DBA/2 * SJL
abnormal dermis papillary layer morphology J:95380
abnormal memory T cell physiology J:95380
decreased lymphocyte cell number J:95380
decreased thymocyte number J:95380
increased CD4-positive, alpha beta T cell number J:95380
seborrheic dermatitis J:95380
thick epidermis J:95380
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129P2/OlaHsd * C57BL/6
abnormal T-helper 1 cell number J:189919
decreased interferon-gamma secretion J:189919
decreased interleukin-2 secretion J:189919
decreased interleukin-10 secretion J:189919
decreased T cell proliferation J:189919
decreased T-helper 2 cell number J:189919
decreased T-helper 17 cell number J:189919
increased interferon-gamma secretion J:189919
increased interleukin-6 secretion J:189919
increased interleukin-17 secretion J:189919
increased T cell apoptosis J:189919
increased T cell proliferation J:189919
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:83278
abnormal cytokine secretion J:83278
abnormal eye morphology J:83278
abnormal optic nerve morphology J:83278
axon degeneration J:83278
blepharitis J:83278
CNS inflammation J:83278
demyelination J:83278
edema J:83278
eyelid edema J:83278
increased cell proliferation J:83278
increased sensitivity to induced morbidity/mortality J:83278
increased susceptibility to autoimmune disorder J:83278
increased susceptibility to experimental autoimmune encephalomyelitis J:83278
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
involves: C57BL/6 * CD-1
decreased interleukin-17 secretion J:125296
Tg(Tcra5CC7,Tcrb5CC7)IWep/0
involves: C57BL/6
abnormal T cell activation J:73608
Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0
involves: C57BL/6 * DBA/2
abnormal positive T cell selection J:125548
Tg(Tcra,Tcrb)3Ayr/0
involves: C57BL/6 * DBA/2
abnormal lymphocyte anergy J:80775
abnormal positive T cell selection J:125548
decreased T cell proliferation J:80775
Tg(Tcra,Tcrb)24Efro/0
D1.Cg-Tg(Tcra,Tcrb)24Efro
abnormal cytokine secretion J:104243
abnormal T cell differentiation J:104243
autoimmune response J:104243
decreased T cell proliferation J:104243
increased autoantibody level J:104243
increased memory T cell number J:104243
increased susceptibility to autoimmune disorder J:104243
increased T cell proliferation J:104243
Tg(Tcra,Tcrb)HRCAll/0
B6.Cg-Tg(Tcra,Tcrb)HRCAll
abnormal T cell subpopulation ratio J:131347
decreased CD4-positive, alpha beta T cell number J:131347
decreased cytotoxic T cell cytolysis J:131347
decreased interferon-gamma secretion J:131347
increased CD8-positive, alpha-beta T cell number J:131347
Tg(Tcra,Tcrb)HRVAll/0
B6.Cg-Tg(Tcra,Tcrb)HRVAll
abnormal T cell subpopulation ratio J:131347
decreased CD4-positive, alpha beta T cell number J:131347
increased CD8-positive, alpha-beta T cell number J:131347
Tg(Tcra,Tcrb)HRVAll/0
Tg(TRAMP)8247Ng/0
B6.Cg-Tg(Tcra,Tcrb)HRVAll Tg(TRAMP)8247Ng
increased prostate gland tumor incidence J:131347
increased tumor incidence J:131347
premature death J:131347
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD-Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
abnormal CD4-positive, alpha beta T cell morphology J:93553
abnormal CD8-positive, alpha beta T cell morphology J:94192
abnormal cytotoxic T cell physiology J:94192
increased susceptibility to autoimmune diabetes J:94192
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: C57BL/6 * NOD * SJL
decreased dendritic cell number J:137009
normal digestive/alimentary phenotype J:135214
normal immune system phenotype J:135214
insulitis J:137009
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
decreased susceptibility to autoimmune diabetes J:87251
increased activated T cell number J:52940
insulitis J:52940
Tg(TcraCl1,TcrbCl1)1Shrm/0
B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm
abnormal fertility/fecundity J:106230
abnormal T cell subpopulation ratio J:97745
increased tumor incidence J:106230
weakness J:106230
Tg(TcraCl4,TcrbCl4)1Shrm/?
B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm
abnormal CD8-positive, alpha-beta T cell differentiation J:99756
abnormal T cell subpopulation ratio J:99756
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/6 * DBA/2J
abnormal cytotoxic T cell physiology J:66565
abnormal T cell differentiation J:97610
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/6J * C57L/J * DBA/2J
abnormal double-negative T cell morphology J:79738
abnormal T cell differentiation J:79738, J:90776
decreased thymocyte number J:79738
thymus hypoplasia J:79738
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
abnormal negative T cell selection J:151074
abnormal positive T cell selection J:151074
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themistm1Lov/Themistm1Lov
involves: 129 * C57BL/6 * DBA/2
abnormal negative T cell selection J:151075
abnormal positive T cell selection J:151075
decreased single-positive T cell number J:151075
increased double-positive T cell number J:151075
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal negative T cell selection J:84536
abnormal thymus morphology J:84536
increased thymocyte number J:84536
Tg(TcrAND)53Hed/?
involves: A/WySnSg * C57BL/6 * C57BL/10SnSg * SJL
abnormal positive T cell selection J:85777
abnormal T cell differentiation J:85777
abnormal T cell proliferation J:85777
abnormal T cell subpopulation ratio J:85777
abnormal thymocyte activation J:85777
decreased CD8-positive, alpha-beta T cell number J:85777
decreased double-positive T cell number J:85777
increased CD4-positive, alpha beta T cell number J:85777
Tg(TcrAND)53Hed/?
involves: C57BL/6 * SJL
abnormal lymph node cell ratio J:124701
increased CD4-positive, alpha beta T cell number J:124701
Tg(TcrAND)53Hed/?
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal positive T cell selection J:151074
decreased CD4-positive, alpha beta T cell number J:151074
decreased CD8-positive, alpha-beta T cell number J:151074
increased double-positive T cell number J:151074
Tg(TcrAND)53Hed/?
Themistm1Lov/Themistm1Lov
involves: 129 * C57BL/6 * SJL
abnormal positive T cell selection J:151075
decreased single-positive T cell number J:151075
increased double-positive T cell number J:151075
Tg(TcrAND)53Hed/?
Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
involves: C57BL/6 * SJL
abnormal T cell differentiation J:141145
Tg(TcraR28,TcrbR28)KRNDim/0
involves: C57BL/6 * NOD * SJL
abnormal intervertebral disk morphology J:36815
abnormal lymphocyte cell number J:36815
abnormal macrophage chemotaxis J:36815
abnormal metatarsal bone morphology J:36815
abnormal phalanx morphology J:36815
abnormal T cell activation J:36815
abnormal T cell anergy J:36815
abnormal T cell clonal deletion J:36815
abnormal T cell proliferation J:36815
chronic joint inflammation J:36815
clinodactyly J:36815
decreased CD4-positive, alpha beta T cell number J:36815
decreased CD8-positive, alpha-beta T cell number J:36815
decreased joint mobility J:36815
enlarged spleen J:36815
glomerulonephritis J:36815
impaired neutrophil recruitment J:36815
increased B cell number J:36815
increased IgG1 level J:36815
kidney inflammation J:36815
renal glomerular immunoglobulin deposits J:36815
rheumatoid arthritis J:36815
Tg(TcraTcrb)8Rest/?
C57BL/6-Tg(TcraTcrb)8Rest
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:85058
abnormal cytotoxic T cell physiology J:85058
altered tumor susceptibility J:85058
increased interferon-gamma secretion J:85058
Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6
abnormal positive T cell selection J:125548
Tg(TcraTcrb)425Cbn/?
involves: BALB/c * C57BL/6
abnormal positive T cell selection J:87876
increased CD4-positive, alpha beta T cell number J:87876
Tg(TcraTcrb)425Cbn/0
involves: C57BL/6
abnormal cytokine level J:112600
Tg(TcraTcrb)425Cbn/0
Trim30atm1Yjk/Trim30atm1Yjk
involves: 129P2/OlaHsd * BALB/c * C57BL/6
increased T cell proliferation J:215171
Tg(TcraTcrb)425Cbn/0
Trip10tm1.1Geha/Trip10tm1.1Geha
B6.Cg-Trip10tm1.1Geha Tg(TcraTcrb)425Cbn
abnormal effector T cell morphology J:164363
decreased CD4-positive, alpha beta T cell number J:164363
normal immune system phenotype J:164363
Tg(TcraTcrb)1100Mjb/?
either: C57BL/6 or (involves: C57BL/6 * SJL)
increased tumor latency J:134776
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6
abnormal CD8-positive, alpha beta T cell morphology J:92867
abnormal cytotoxic T cell physiology J:92867, J:133645
abnormal positive T cell selection J:92867, J:133645
abnormal T cell clonal deletion J:92867
abnormal T cell subpopulation ratio J:92867, J:133645
decreased CD4-positive, alpha beta T cell number J:133645
increased CD8-positive, alpha-beta T cell number J:92867, J:133645
increased T cell proliferation J:92867
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * MRL/Mp
increased hepatocyte apoptosis J:72817
increased sensitivity to xenobiotic induced morbidity/mortality J:72817
liver inflammation J:72817
pale liver J:72817
Tg(TcraTcrb)1100Mjb/?
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6
abnormal positive T cell selection J:151074
decreased CD8-positive, alpha-beta T cell number J:151074
increased double-positive T cell number J:151074
Tg(TcraTcrbNY4.1)1Pesa/0
NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa
increased susceptibility to autoimmune diabetes J:108768
insulitis J:108768
Tg(TcraTcrbNY8.3)1Pesa/?
involves: C57BL/6 * NOD * SJL
increased circulating glucose level J:44202
pancreas inflammation J:44202
Tg(TcraY1,TcrbY1)416Tev/0
involves: C57BL/6J * DBA/2J
abnormal immune tolerance J:84288
Tg(TcrHEL3A9)1Mmd/0
involves: C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:73608
abnormal interleukin secretion J:73608
abnormal T cell activation J:73608
increased T cell proliferation J:73608
Tg(TcrHEL3A9)1Mmd/0
involves: C57BL/6 * C57BL/10 * C57BR/cd
abnormal CD4-positive, alpha beta T cell morphology J:78309
abnormal double-positive T cell morphology J:78309
abnormal T cell activation J:78309
abnormal T cell proliferation J:78309
abnormal thymus cell ratio J:78309
decreased CD4-positive, alpha beta T cell number J:78309
Tg(TcrHEL3A9)1Mmd/0
Tg(TLK2mHEL)2Ccg/0
involves: C57BL/6 * C57BL/10 * C57BR/cd
abnormal CD4-positive, alpha beta T cell morphology J:78309
abnormal CD4-positive, alpha-beta T cell physiology J:78309
abnormal T cell activation J:78309
abnormal T cell proliferation J:78309
decreased CD4-positive, alpha beta T cell number J:78309
decreased double-positive T cell number J:78309
thyroid gland inflammation J:78309
Tg(TcrLCMV)1Aox/?
C57BL/6-Tg(TcrLCMV)1Aox
abnormal cytotoxic T cell physiology J:92228
decreased CD8-positive, alpha-beta T cell number J:92228
decreased double-positive T cell number J:92228
increased CD4-positive, alpha beta T cell number J:92228
increased double-negative T cell number J:92228
increased IgG level J:92228
Tg(TcrLCMV)2Aox/?
C57BL/6-Tg(TcrLCMV)2Aox
abnormal cytotoxic T cell physiology J:92228
decreased CD8-positive, alpha-beta T cell number J:92228
decreased double-positive T cell number J:92228
increased CD4-positive, alpha beta T cell number J:92228
increased double-negative T cell number J:92228
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6 * DBA/2
decreased CD8-positive, alpha-beta T cell number J:77696
decreased cytotoxic T cell cytolysis J:77696
decreased double-positive T cell number J:77696
decreased T cell proliferation J:77696
thymus hypoplasia J:77696
Tg(TcrLCMV)327Sdz/?
involves: C57BL/6 * DBA/2J
abnormal T cell differentiation J:97610
decreased CD4-positive, alpha beta T cell number J:97610
Tg(TcrLCMV)327Sdz/Tg(TcrLCMV)327Sdz
NOD.Cg-Tg(TcrLCMV)327Sdz/Dvs
autoimmune response J:71050
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL
increased regulatory T cell number J:196160
increased susceptibility to autoimmune diabetes J:196160
increased T-helper 1 cell number J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL
abnormal abdominal lymph node morphology J:196160
abnormal immune serum protein physiology J:196160
abnormal immune system morphology J:196160
abnormal immune system organ morphology J:196160
abnormal immune system physiology J:196160
abnormal interleukin secretion J:196160
abnormal spleen morphology J:196160
decreased interleukin-9 secretion J:196160
decreased interleukin-17 secretion J:196160
decreased regulatory T cell number J:196160
normal immune system phenotype J:196160
increased interferon-gamma secretion J:196160
increased interleukin-2 secretion J:196160
increased interleukin-21 secretion J:196160
increased regulatory T cell number J:196160
increased susceptibility to autoimmune diabetes J:196160
normal mortality/aging J:196160
pancreas inflammation J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Foxp3-EGFP/cre)1cJbs/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL
normal immune system phenotype J:196160
increased regulatory T cell number J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129 * C57BL/6 * NOD * SJL
normal immune system phenotype J:196160
increased susceptibility to autoimmune diabetes J:196160
Tigittm1Sdl/Tigittm1Sdl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: C57BL/6
decreased interleukin-10 secretion J:168902
increased susceptibility to experimental autoimmune encephalomyelitis J:168902
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S5/SvEvBrd * C57BL/6
increased susceptibility to experimental autoimmune encephalomyelitis J:222944
Xcl1tm1Rakr/Xcl1tm1Rakr
Tg(TcraTcrb)1100Mjb/0
involves: 129/Sv * C57BL/6
abnormal CD8-positive, alpha-beta T cell physiology J:155297
decreased cytotoxic T cell cytolysis J:155297
decreased interferon-gamma secretion J:155297
decreased T cell number J:155297
Zap70m1Saka/Zap70m1Saka
Tg(DO11.10)10Dlo/0
involves: BALB/c * C3H * C57BL/6
decreased T cell number J:86607
decreased T cell proliferation J:86607
Zap70m1Saka/Zap70m1Saka
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: BALB/c * C57BL/6J * DBA/2J
abnormal positive T cell selection J:86607
arthritis J:86607
Zap70tm1.1Mmal/Zap70tm1.1Mmal
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J
normal immune system phenotype J:71099
Zap70tm1.1Mmal/Zap70tm1.1Mmal
Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2
abnormal cytokine secretion J:71099
abnormal T cell proliferation J:71099
normal immune system phenotype J:71099
Zap70tm2.1Mmal/Zap70tm2.1Mmal
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J
abnormal lymph node cell ratio J:71099
abnormal T cell morphology J:71099
abnormal thymus cell ratio J:71099
normal immune system phenotype J:71099
Zap70tm2.1Mmal/Zap70tm2.1Mmal
Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2
abnormal T cell morphology J:71099
normal immune system phenotype J:71099
Zap70tm2.1Weis/Zap70tm2.1Weis
Tg(DO11.10)10Dlo/?
involves: 129S4/SvJae * BALB/c * C3H * C57BL/6
abnormal positive T cell selection J:154166
Zap70tm2.1Weis/Zap70tm2.1Weis
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S4/SvJae * C57BL/6J * DBA/2J
abnormal positive T cell selection J:154166
abnormal T cell clonal deletion J:154166

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory