100 phenotypes from 14 alleles in 24 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sox10Dal/Sox10+ C57BL/6J-Sox10Dal	variable body spotting	J:132358
Sox10df8R/Sox10+ involves: 129X1/SvJ * C57BL/6J	belly spot	J:102039
Sox10Dom/Sox10+ C3Fe.B6JLe-Sox10Dom	abnormal enteric ganglia morphology	J:165146
	abnormal enteric nervous system morphology	J:165146
	abnormal enteric neural crest cell morphology	J:165146
	abnormal neural crest cell physiology	J:165146
Sox10Dom/Sox10+ C57BL/6J-Sox10Dom	abnormal enteric ganglia morphology	J:165146
	abnormal enteric nervous system morphology	J:165146
	abnormal enteric neural crest cell morphology	J:165146
	abnormal neural crest cell physiology	J:165146
	aganglionic megacolon	J:165146
Sox10Dom/Sox10+ involves: C3HeB/FeJLe * C57BL/6JLe	abnormal enteric neuron morphology	J:45117
	abnormal neural crest cell migration	J:45117
Sox10Dom/Sox10+ involves: C57BL/6JLe	lethality at weaning, incomplete penetrance	J:7688
	megacolon	J:7688
	variable body spotting	J:7688
Sox10Dom/Sox10+ Tg(DBHn-lacZ)8Rpk/0 involves: C3HeB/FeJLe * C57BL/6JLe * SJL	abnormal colon morphology	J:32868
	abnormal intestine morphology	J:32868
	abnormal parasympathetic ganglion morphology	J:32868
	abnormal rectum morphology	J:32868
	abnormal vagal neural crest cell migration	J:32868
	white spotting	J:32868
Sox10Dom/Sox10Dom involves: C3HeB/FeJLe * C57BL/6JLe	abnormal cranial ganglia morphology	J:67383
	abnormal dorsal root ganglion morphology	J:67383
	abnormal melanocyte differentiation	J:45117
	abnormal neural crest cell migration	J:45117
	abnormal nodose ganglion morphology	J:67383
	abnormal PNS glial cell morphology	J:67383
	abnormal Schwann cell morphology	J:67383
	abnormal sensory neuron morphology	J:67383
	abnormal spinal nerve morphology	J:67383
	abnormal superior cervical ganglion morphology	J:67383
	abnormal sympathetic ganglion morphology	J:67383
	abnormal ventral spinal root morphology	J:67383
	absent enteric neural crest cell	J:67383
	dorsal root ganglion degeneration	J:67383
	motor neuron degeneration	J:67383
	small dorsal root ganglion	J:45117
Sox10Dom/Sox10Dom involves: C57BL/6JLe	embryonic lethality, complete penetrance	J:7688
Sox10gt/Sox10+ GT/Le	brain vacuoles	J:216967
Sox10gt/Sox10+ involves: HYIII/LeJ	spongiform encephalopathy	J:7723
Sox10gt/Sox10gt GT/Le	belly spot	J:216967
	brain vacuoles	J:216967
	decreased foot pigmentation	J:216967
	diluted coat color	J:216967
	dysmyelination	J:216967
	gliosis	J:216967
	head blaze	J:216967
	megacolon	J:216967
	non-pigmented tail tip	J:216967
	premature death	J:216967
	spongiform encephalopathy	J:216967
	tremors	J:216967
Sox10gt/Sox10gt involves: C57BL/6 * GT/Le	abnormal myelination	J:216967
	head blaze	J:216967
	premature death	J:216967
	seizures	J:216967
Sox10gt/Sox10gt involves: HYIII/LeJ	abnormal digestive system physiology	J:7723
	absent skin pigmentation	J:7723
	belly spot	J:7723
	darkened coat color	J:7723
	demyelination	J:7723
	head blaze	J:7723
	premature death	J:7723
	spongiform encephalopathy	J:7723
	sporadic seizures	J:7723
	tremors	J:7723
Sox10gt/Sox10tm1Weg involves: 129S1/Sv * 129X1/SvJ * GT/Le	absent coat pigmentation	J:216967
	brain vacuoles	J:216967
	decreased melanocyte number	J:216967
	megacolon	J:216967
	postnatal lethality, complete penetrance	J:216967
Sox10M2Btlr/? C57BL/6J-Sox10M2Btlr	belly spot	J:200817
	decreased foot pigmentation	J:200817
Sox10M2J/Sox10+ B6Ei.Cg-Sox10M2J/GrsrJ	decreased foot pigmentation	J:181083
	decreased tail pigmentation	J:181083
	variable body spotting	J:181083
Sox10tm1.1Sout/Sox10tm1.1Sout involves: C57BL/6N	no abnormal phenotype detected	J:200671
Sox10tm1Ngan/Sox10+ involves: 129S/SvEv * C57BL/6	dilated cochlea	J:332093
Sox10tm1Ngan/Sox10tm1Ngan involves: 129S/SvEv * C57BL/6	dilated cochlea	J:332093
Sox10tm1Weg/Sox10+ C3HeB/FeJ-Sox10tm1Weg	aganglionic megacolon	J:296651
	belly spot	J:296651
	hypopigmentation	J:296651
Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ	brain vacuoles	J:216967
Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ * C3H	abnormal oligodendrocyte physiology	J:260791
	belly spot	J:260791
	megacolon	J:260791
Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	belly spot	J:67383
	decreased melanocyte number	J:67383
	megacolon	J:67383
	postnatal lethality, incomplete penetrance	J:67383
Sox10tm1Weg/Sox10tm1Weg involves: 129S1/Sv * 129X1/SvJ	abnormal axon fasciculation	J:203636
	abnormal axon guidance	J:203636
	abnormal axon morphology	J:203636
	abnormal frontonasal mesenchyme morphology	J:203636
	abnormal glial cell morphology	J:203636
	abnormal olfactory bulb morphology	J:203636
	decreased cell migration	J:203636
Sox10tm1Weg/Sox10tm1Weg involves: 129S1/Sv * 129X1/SvJ * C3H	abnormal oligodendrocyte physiology	J:260791
	absent Schwann cells	J:260791
Sox10tm1Weg/Sox10tm1Weg involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	abnormal dorsal root ganglion morphology	J:67383
	abnormal limb posture	J:67383
	abnormal melanoblast morphology	J:67383
	abnormal neural crest morphology	J:67383
	abnormal PNS glial cell morphology	J:67383
	cyanosis	J:67383
	decreased melanocyte number	J:67383
	perinatal lethality, incomplete penetrance	J:67383
	respiratory failure	J:67383
	unresponsive to tactile stimuli	J:67383
Sox10tm2(rtTA)Weg/Sox10+ involves: 129P2/OlaHsd	abnormal coat/hair pigmentation	J:94207
	belly spot	J:94207
	megacolon	J:94207
Sox10tm2(rtTA)Weg/Sox10tm2(rtTA)Weg involves: 129P2/OlaHsd	perinatal lethality, complete penetrance	J:94207
	prenatal lethality, incomplete penetrance	J:94207
Sox10tm3(Sox8)Weg/Sox10+ involves: 129P2/OlaHsd * FVB/N	normal digestive/alimentary phenotype	J:119015
Sox10tm3(Sox8)Weg/Sox10tm3(Sox8)Weg involves: 129P2/OlaHsd * FVB/N	abnormal enteric neural crest cell migration	J:119015
	abnormal enteric neuron morphology	J:119015
	abnormal melanoblast morphology	J:119015
	abnormal sympathetic ganglion morphology	J:119015
	absent coat pigmentation	J:119015
	absent hair follicle melanin granules	J:119015
	decreased oligodendrocyte number	J:119015
	increased vagal neural crest cell apoptosis	J:119015
	normal nervous system phenotype	J:119015
	postnatal growth retardation	J:119015
	postnatal lethality, complete penetrance	J:119015
Sox10tm4Weg/Sox10+ involves: 129P2/OlaHsd * C3H	belly spot	J:124679
	normal digestive/alimentary phenotype	J:124679
Sox10tm4Weg/Sox10tm4Weg involves: 129P2/OlaHsd * C3H	abnormal enteric neuron morphology	J:124679
	abnormal melanoblast migration	J:124679
	abnormal Schwann cell morphology	J:124679
	aganglionic megacolon	J:124679
	dorsal root ganglion hypoplasia	J:124679
	neonatal lethality, incomplete penetrance	J:124679
	normal nervous system phenotype	J:124679
	postnatal lethality, complete penetrance	J:124679
Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg Tg(Dhh-cre)1Mejr/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	abnormal action potential	J:162692
	abnormal gait	J:162692
	abnormal limb posture	J:162692
	abnormal locomotor behavior	J:162692
	abnormal myelination	J:162692
	abnormal neuron proliferation	J:162692
	abnormal Schwann cell morphology	J:162692
	abnormal sciatic nerve morphology	J:162692
	decreased body weight	J:162692
	decreased nerve conduction velocity	J:162692
	impaired coordination	J:162692
	increased neuron apoptosis	J:162692
	postnatal growth retardation	J:162692
	premature death	J:162692
	tremors	J:162692
Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg Tg(Pou3f4-cre)32Cren/0 involves: 129P2/OlaHsd * CD-1	decreased oligodendrocyte number	J:324574
Sox10tm8.1Weg/Sox10+ involves: 129P2/OlaHsd * C3H	abnormal oligodendrocyte physiology	J:260791
	belly spot	J:260791
	megacolon	J:260791
Sox10tm8.1Weg/Sox10tm8.1Weg involves: 129P2/OlaHsd * C3H	abnormal nervous system morphology	J:260791
	abnormal oligodendrocyte physiology	J:260791
	abnormal Schwann cell physiology	J:260791
	decreased Schwann cell number	J:260791
	neonatal lethality, complete penetrance	J:260791