Sox1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sox1
SRY (sex determining region Y)-box 1
MGI:98357

39 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dicer1^tm1Bdh/Dicer1^tm1Bdh Sox1^tm1(cre)Take/Sox1⁺ involves: 129 * C57BL/6NCrlj * CBA/JNCrlj	perinatal lethality, complete penetrance	J:244791
	short rostral-caudal axis	J:244791
Enpp2^tm1.1Vart/Enpp2^tm1.1Vart Sox1^tm2Vep/Sox1⁺ involves: C57BL/6	abnormal neural tube morphology	J:159118
	kinked neural tube	J:159118
	open neural tube	J:159118
Eomes^tm1Rob/Eomes^tm1Rob Sox1^tm1(cre)Take/0 involves: 129S/SvEv * C57BL/6 * CBA	abnormal axon guidance	J:138764
	abnormal dentate gyrus morphology	J:138764
	abnormal neuron apoptosis	J:138764
	abnormal neuronal precursor proliferation	J:138764
	abnormal olfactory bulb morphology	J:138764
	absent anterior commissure	J:138764
	decreased brain size	J:138764
	decreased grip strength	J:138764
	increased aggression towards humans	J:138764
	increased aggression towards mice	J:138764
	increased exploration in new environment	J:138764
	small olfactory bulb	J:138764
	thin cerebral cortex	J:138764
Fkrp^tm1Scbr/Fkrp^tm1Scbr Sox1^tm1(cre)Take/Sox1⁺ involves: C57BL/6NCrlj * CBA/JNCrlj	centrally nucleated skeletal muscle fibers	J:207119
	decreased body weight	J:207119
	dystrophic muscle	J:207119
	hydrocephaly	J:207119
	muscle degeneration	J:207119
	myositis	J:207119
	postnatal lethality, incomplete penetrance	J:207119
Fkrp^tm1Scbr/Fkrp^tm1Scbr Sox1^tm1(cre)Take/Sox1⁺ Tg(CAG-LARGE)126Fmu/0 involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	abnormal muscle morphology	J:207119
	abnormal muscle physiology	J:207119
	abnormal reflex	J:207119
	calcified muscle	J:207119
	centrally nucleated skeletal muscle fibers	J:207119
	dystrophic muscle	J:207119
	myositis	J:207119
	premature death	J:207119
	skeletal muscle fibrosis	J:207119
	skeletal muscle hypertrophy	J:207119
Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Sox1^tm1(cre)Take/Sox1⁺ involves: C57BL/6NCrlj * CBA/JNCrlj	normal cardiovascular system phenotype	J:203163
	normal embryo phenotype	J:203163
	normal hematopoietic system phenotype	J:203163
	normal mortality/aging	J:203163
Sox1^tm1Vep/Sox1^tm1Vep Sox2^tm1Vep/Sox2⁺ involves: 129S/SvEv	abnormal olfactory cortex morphology	J:99610
Sox1^tm1Vep/Sox1^tm2Vep Sox2^tm1Vep/Sox2⁺ involves: 129S/SvEv	abnormal olfactory cortex morphology	J:99610
	microphthalmia	J:99610
	premature death	J:99610
	seizures	J:99610

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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