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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Srsf1
serine/arginine-rich splicing factor 1
MGI:98283
19 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Myl2tm1(cre)Krc/Myl2+
Srsf1tm1Xdfu/Srsf1tm1Xdfu
involves: 129S4/SvJae
abnormal cardiac muscle contractility J:96039
abnormal myocardial fiber morphology J:96039
cardiac fibrosis J:96039
cardiac hypertrophy J:96039
decreased heart rate J:96039
dilated cardiomyopathy J:96039
premature death J:96039
thin ventricular wall J:96039
Srsf1tm1.1Xdfu/Srsf1tm1.1Xdfu
involves: 129S4/SvJae
embryonic lethality between implantation and somite formation, complete penetrance J:96039
Srsf1tm1Xdfu/Srsf1tm1Xdfu
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
involves: 129S4/SvJae * C57BL/6 * SJL
abnormal horizontal cell morphology J:143205
abnormal optic nerve morphology J:143205
abnormal retina inner limiting membrane morphology J:143205
abnormal retina morphology J:143205
abnormal retinal ganglion layer morphology J:143205
decreased amacrine cell number J:143205
decreased retinal ganglion cell number J:143205
increased retinal apoptosis J:143205
microphthalmia J:143205
retinal degeneration J:143205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory